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Biomedical subjects

F Colardyn

Publications and source records attributed to F Colardyn.

34 records · Page 2Linked to original sources
PubMed1988

Effect of propofol on elevated intracranial pressure. Preliminary results.

The effects of a bolus injection of propofol on mean intracranial pressure were studied in six adult, comatose patients who had severe head injuries. Propofol 2 mg/kg was given intravenously over 90 seconds when the mean intracranial pressure reached or exceeded 25 mmHg. Arterial blood gas values, heart rate and central venous pressure remained stable at all measurements. Arterial blood pressure decreased statistically significantly (p less than 0.05) within one minute after propofol administration. The mean (SEM) intracranial pressure decreased statistically significantly (p less than 0.05) at 30 seconds and at 1 and 2 minutes, from 25 (3) to 11 (4) mmHg. The cerebral perfusion pressure decreased statistically significantly from 92 (8) mmHg at all measurements (p less than 0.05). The lowest value at 3 minutes was 50 (7) mmHg but in four patients at that time the perfusion pressure was below 50 mmHg.

Adult↗
PubMed1988

Binding of drugs to end-line filters: a study of four commonly administered drugs in intensive care units.

The binding of diazepam, digoxin, dopamine and fentanyl to different 0.2 microns end-line filters was investigated under simulated infusion conditions. All the drugs were diluted in either 5% dextrose or 0.9% NaCl infusion fluid. For digoxin and diazepam a marked reduction in the amount of drug delivered to the patient in the first 20-60 min of infusion is observed. For dopamine, the drug loss was less pronounced and no fentanyl was absorbed to the filters during the infusion experiment.

Absorption↗
PubMed1988

The sorption of isosorbide dinitrate to intravenous delivery systems.

The sorption of isosorbide dinitrate from 0.9% sodium chloride and 10% glucose solutions, by intravenous delivery systems has been investigated under simulated infusion conditions. Isosorbide dinitrate was stable in both 0.9% sodium chloride and 10% glucose solutions. Intravenous fluid containers, burettes, a syringe, infusion sets and end-line filters were evaluated. Glass containers, methacrylate butadiene styrene burettes and polybutadiene giving sets did not sorb isosorbide dinitrate. Neither did polypropylene syringes when a 10% glucose solution was used. The sorption of isosorbide dinitrate to end-line filters was unimportant but there was a significant loss to the PVC tubing used to connect the filter housing to the catheter.

Adsorption↗
PubMed1987

Cardiac contusion.

During a consecutive period of 24 months, 244 patients with a major trauma were admitted to the Intensive Care Unit. From this pool of patients 60 consecutively were selected who did fulfill the selected criteria. We intended to determine within this studygroup the incidence, clinical features and outcome of patients with myocardial contusion (MC). We could conclude that no currently used diagnostic test may be seen as an accurate prediction of patients who still develop morbidity or mortality from cardiac contusion. Data from the literature suggest that at present only radionuclide angiography, direct hemodynamic measurement with construction of a Starling curve, and/or 2D-echocardiography may be useful in the identification of the patients at the greatest risk and predictive of the severity of the myocardial injury.

Adult↗
PubMed1987

Renal function in burns.

The present study evaluates the evolution of renal function parameters and serum electrolytes in 34 severely burned patients. The population was arbitrarily subdivided in a group with normal renal function (n = 24) and a group with acute renal failure (n = 10), defined by the fact that serum creatinine rose above 2.5 mg/dl at least once. The patient group with normal renal function was characterized by a normal to high creatinine clearance, reaching a consistent peak at day 2 of follow-up. Serum sodium and fractional sodium excretion were low. Further disturbances were a low serum protein, an early hypocalcemia and hypophosphatemia, and a discrete metabolic alkalosis. The patients developing acute renal failure maintained a low fractional sodium excretion. They were in general of older age and had more severe burns than the patients with normal renal function. The survival rate in the patients with acute renal failure was 30%, compared to 75% in the patients, who maintained normal renal function.

Acute Kidney Injury↗
PubMedDate not supplied

Infections in patients in intensive care units: can the combination of a monobactam and a penicillin replace the classic combination of a beta-lactam agent and an aminoglycoside?

An open, comparative, randomized study was performed in two medical intensive care units to compare the efficacy of the combination of aztreonam and either cloxacillin or oxacillin [(cl)oxacillin] with that of the combination of tobramycin and a cephalosporin. Of the 92 patients who were included in the study, 76 were evaluable. All patients suffered from severe, mostly pulmonary, infections and received ventilatory support. The aztreonam combination yielded an 80% rate of clinical cure; mortality was 15%. Use of the aminoglycoside combination resulted in a 51% rate of clinical cure; mortality was 23%. The difference in cure rate between the two combinations was statistically significant. Adverse effects were negligible in patients who received the aztreonam combination, and superinfection was seen in only 2%. Of the patients who received the aminoglycoside combination, 20% developed a superinfection and 11% developed a new renal insufficiency. Therefore, the combination of aztreonam and (cl)oxacillin is a valuable alternative to the combination of an aminoglycoside and a cephalosporin.

Adult↗
PubMedDate not supplied

Peripheral vascular effects of calcium entry blockers in normal volunteers.

The peripheral vascular effects of calcium entry blockers have been scarcely investigated. Therefore we examined the effects of different doses of tiapamil and nifedipine in two groups of volunteers. The measurements were done by plethysmography. At a lower dose there is a significant increase in venous capacity. At a higher dosage there is an increase of the arterial flow, eliciting a reflex sympathetic stimulation with heart rate increase and venoconstriction. Therefore calcium entry blockers can be considered as arterial and venodilators.

Adult↗