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Biomedical subjects

F Clavel-Chapelon

Publications and source records attributed to F Clavel-Chapelon.

60 records · Page 4Linked to original sources
PubMed1995

Reproductive factors and breast cancer risk. Effect of age at diagnosis.

The data from a French case-control study of 495 patients with breast cancer and 542 control subjects interviewed in five French public hospitals, were analyzed to assess the effect of reproductive factors (age at menarche, age at first full-term pregnancy, the time interval between these two ages, and parity) on the risk of breast cancer. Age at menarche, age at first full-term pregnancy, the time interval between these two ages, and parity appeared to have a limited influence on breast cancer risk. However, the relationship between these factors and the risk of breast cancer varied according to the age at breast cancer diagnosis. In the youngest group of women, the most consistent effects came from factors occurring early in life (menarche, first full-term pregnancy, and consequently the time interval between these two events). These factors had a null or weak effect on the oldest group of women. The protective effect of high parity was confined to the oldest group of women.

Adult↗
PubMed1992

Exposure to vinyl chloride monomer: results of a cohort study after a seven year follow up. The French VCM Group.

In 1980 a prospective cohort study of exposed and non-exposed subjects was initiated in France by the Institut National de la Santé et de la Recherche Médicale (INSERM U287) in collaboration with occupational physicians from the companies involved. The aim was to evaluate the association between mortality and cancer morbidity and occupational exposure to vinyl chloride monomer (VCM). A total of 1100 subjects exposed to VCM and 1100 non-exposed controls matched for age (to two years), plant, and physician were followed up for seven years (8299 and 8202 person years for exposed subjects and controls respectively) for vital status and health and occupational state. Forty deaths occurred among exposed and 43 among non-exposed subjects (relative risk (RR) = 1.0; 95% confidence interval (95% CI) 0.6-1.5). Forty eight and 32 cases of cancer were reported among exposed and non-exposed subjects, respectively (RR = 1.3; 95% CI 0.8-2.1). Three cases of angiosarcoma of the liver occurred in the exposed group. Eight cases of lung cancer occurred among exposed subjects and six among non-exposed subjects. Fourteen cases of Raynaud's disease were found among exposed and one among non-exposed subjects and the difference was significant. One hundred and twenty three and 93 cases of cardiovascular disease (Raynaud's disease excluded) occurred in the exposed and non-exposed groups respectively (RR = 1.4; 95% CI 1.0-1.8); this difference was mainly due to hypertension. The test for an increasing risk with increased exposure was significant. The percentages of diseases of the respiratory system did not differ between the two groups (RR = 1.1; 95% CI 0.7-1.8).

Cardiovascular Diseases↗
PubMed1992

A randomised 2 x 2 factorial design to evaluate different smoking cessation methods.

A study with a 2 x 2 factorial design was performed to evaluate the effectiveness of acupuncture, of nicotine gum and the effect of the association on smoking cessation. After a one-year follow-up period, the success rates were in the same order of magnitude for nicotine gum (active treatment: 10%, placebo: 8%) group and for acupuncture (active treatment: 8%, placebo: 10%) group.

Acupuncture Therapy↗
PubMedDate not supplied

Smoking cessation rates 4 years after treatment by nicotine gum and acupuncture.

BACKGROUND: This study was done to estimate the smoking cessation rates 4 years after treatment with acupuncture and nicotine gum. METHODS: Participants were randomized in a 2 x 2 factorial design to four groups: double active treatments (nicotine gum and acupuncture), double placebo, and the combination of one active treatment and placebo. RESULTS: The success rates were quite similar in the four groups at the different points of follow-up. They sharply decreased between 1 month (around 23%) and 1 year (around 10%). The decrease slowed down thereafter to around 6% at 4 years. CONCLUSIONS: Results from our study suggest that the two treatments did not offer any long-term improvement over placebo. Additional investigations are necessary to estimate the magnitude of their long-term success rate.

Acupuncture Therapy↗
PubMedDate not supplied

[A biological bank in an epidemiologic study in France: How? Example of the E3N-EPIC study].

The organisation of a bank of biological material as part of an epidemiologic study raises a number of problems. The first part of the paper discusses, in the context of the French regulation, the legal obligations, the administrative problems, the locations selected for the biological sampling, the strategy for sending out invitations to the participants, and the logistic of biological samples transport and storage. The second part presents the solutions brought to these problems in the prospective E3N-EPIC cohort study.

Cohort Studies↗