Biomedical subjects
Publications and source records attributed to F Clark.
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The effect of diazepam on thyroid function tests was examined in 12 euthyroid patients requiring the drug for psychiatric reasons and in six patients with thyrotoxicosis. Assessment was made before and after four weeks' therapy.There was no significant difference in results from tests of thyroid iodide trapping and binding (thyroid radioiodine uptake, thyroid clearance, and absolute iodine uptake) except in the one-hour thyroid uptake in the euthyroid group, which was increased after diazepam. This increase occurred without alteration in serum thyroid stimulating hormone levels. No change occurred in either group in tests of thyroid hormone release (protein-bound iodine, T-3 resin uptake, or Thyopac-3 and free thyroxine index).Patients with suspected thyroid disease who are taking diazepam do not need to stop therapy while their thyroid status is being determined.
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The effect of chlordiazepoxide (Librium) on thyroid function was examined in 14 euthyroid patients who required the drug for psychiatric reasons and in six patients with clinically mild thyrotoxicosis. There was no significant difference in results from tests of thyroid iodide trapping (thyroid radioiodine uptake, thyroid clearance, and absolute iodine uptake) or of thyroid hormone release (protein-bound iodine, T3 resin uptake, and free thyroxine index) carried out before and during treatment with the drug over a four-week period. It is suggested that chlordiazepoxide need not be withdrawn before thyroid status and function are assessed in any patient taking the drug.
Thyopac-3, a new commercial test kit for the in-vitro assessment of thyroid function, has been appraised in a group of 411 patients. The Thyopac-3 test was found to be simple and rapid to perform and accurate in diagnosis. Of 117 patients shown to be euthyroid by other criteria, 5% had Thyopac-3 values outside the normal range (derived from a group of 135 normal patients), and 10 of 79 thyrotoxic and 4 of 37 hypothyroid patients had values within the normal range.In a direct comparison in 190 patients with the resin uptake test the Thyopac-3 test emerged very favourably in regard to diagnostic accuracy and was technically easier and quicker to carry out. There was a non-linear negative correlation between results from the two procedures.
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