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Biomedical subjects

F Chiappetta

Publications and source records attributed to F Chiappetta.

At least 37 records · Page 2Linked to original sources
PubMed1995

Acromegaly and pituitary tumors: early anatomoclinical observations.

The elucidation of pituitary physiopathology has been a major challenge for physicians since early ages. Due to the unawareness of the endocrine system, acromegaly, the most striking pituitary disorder, was commonly regarded as an intrinsic bone disease. Andrea Verga and Vincenzo Brigidi, Italian authors of the 19th century, reported the first macroscopic and microscopic descriptions of pituitary adenomas in acromegalic patients. Although far from providing a correct pathogenetic interpretation of the disease, they opened the way to forthcoming observations and discoveries. A short history of acromegaly and pituitary physiopathology is drawn.

Acromegaly↗
PubMed1995

Celebrating the centennial (1894-1994): Leonardo Gigli and his wire saw.

In spite of the recent introduction of craniotomes in neurosurgical practice, the simple but brilliant wire saw invented by Leonardo Gigli still holds an important place in neurosurgical instrumentation. Born in Florence in 1863, Gigli was forced by circumstances to leave Italy soon after getting his medical degree. He first spent 2 years attending the most celebrated obstetrical clinics in Paris and London and then, in 1892, moved to Breslau where he worked with Fritsch and Mikulicz. During this successful and rewarding period, Gigli proposed the lateralized pubiotomy (Gigli's operation) for safe delivery in cases of maternal pelvic deformities and, inspired by the sight of a jagged knife during a country banquet, conceived his wire saw to simplify the procedure. In 1894, at Professor Obalinski's suggestion, he successfully tested a modified saw type with a whalebone guide for the preparation of osteoplastic cranial flaps. In spite of his great popularity and the high esteem in which he was held abroad, Gigli's aims were systematically belittled in Italy, where he never qualified for a university teaching position. He died in 1908, at age 44. Although the once celebrated Gigli's operation has merely historical interest today, the favorable features of his wire saw make it a safe and efficient tool in the hands of twentieth-century neurosurgeons worldwide.

History, 19th Century↗
PubMed1995

Diffuse leptomeningeal gliomatosis with osteoblastic metastases and no evidence of intraaxial lesions.

An autopsy-proved case of cerebral and medullary leptomeningeal gliomatosis and diffuse osteoblastic metastases without evidence of intraaxial tumor is described. MR findings included diffuse thickening of the cerebral and medullary leptomeninges on T1-weighted, proton density-weighted, and T2-weighted images and abnormal enhancement of the sulci and cisterns of the cerebrum, brain stem, cerebellum, and medulla on postcontrast T1-weighted images. MR also showed several areas of replacement of the normal bone marrow of the skull. No intraaxial lesion was seen.

Adult↗
PubMed1995

Cervical locked facet: operative management.

Cervical locked facet represent 5.6% of cervical lesion. If an identity of views is present in the use of tractions, we can't say as for the setting fixation techniques. Our cases histories (13 cases) and the experience of other authors incline us to support a precocious surgical treatment characterized by a posterior approach and then anterior in the not reduced cases and a single anterior approach in the reduced cases in anesthesia. The good alignment and the attain stability with the double access, but still more the convinction that the lesions of intervertebral disk and ligamentous tissues (as demonstration at the RMN) is always to remove, support us in the undertaken therapeutic attitude.

Adult↗
PubMed1994

Halifax interlaminar clamps for posterior atlanto-axial arthrodesis with spinal fusion by "H" bone+graft.

The use of Halifax interlaminar clamps in posterior arthrodesis for atlanto-axial instabilities has recently been reported. The four Anderson II fractures submitted were surgically treated by posterior arthrodesis with Halifax clamps and bilateral "H" shaped bone-grafts obtained from the iliac crest. Only in the first case--initially treated without fusion--a review of the system became necessary due to the loosening of one clamp. No post-operative neurological complications appeared and non malunion or nonunion occurred at follow-up. Posterior arthrodesis with Halifax clamps does not involve any complication connected with the use of metal wire and the association of posterior fusion by lateral "H" shaped bone grafts ensures a stable and physiological reduction of dens fractures and atlanto-axial luxations/subluxations often associated.

Adult↗
PubMed1994

Cruciate paralysis from a Jefferson's fracture. Report a case and review of the literature.

A case of post-traumatic cruciate paralysis with a Jefferson's fracture was observed in a 54-year-old patient who fell accidentally. Cruciate or Bell's paralysis is a condition caused by incomplete cervical spinal cord lesion linked to focal and reversible damage of the pyramidal tract at the level of the decussation. The patient was treated by S.O.M.I. brace and a Philadelphia collar with a complete neurological restitution.

Cervical Atlas↗
PubMed1983

Prospective study of posttransfusion hepatitis in cardiac surgery patients receiving only blood or also blood products.

The incidence, etiology and risk factors of posttransfusion (PT) hepatitis were evaluated in a prospective study of 297 consecutive open-heart surgery patients. PT hepatitis occurred in 63 (21.2%) patients with a significantly higher hepatitis attack rate in 51 recipients of commercial clotting factor concentrates (56.8%) compared to 246 recipients of blood units from single volunteer donors (13.8% p less than 0.001). Among the concentrates, Prothrombin-complex showed the highest relative hepatitis risk (24) while in patients receiving only blood, the incidence PT hepatitis was correlated with the blood volume transfused. Of the 63 patients with PT hepatitis, 2 (3%) had hepatitis B, 8 (13%) showed evidence of cytomegalovirus infection and 53 (84%) had non-A, non-B hepatitis. These results show that in Italy, as elsewhere, non-A, non-B PT hepatitis is frequent, particularly when commercial blood products are used.

Blood Coagulation Factors↗
PubMedDate not supplied

Recent experience in the management of meningeal hemangiopericytomas.

Although the histogenesis of meningeal hemangiopericytomas (HMP) remains controversial, both biological and clinical evidence seems to identify these neoplasms as a separate entity with respect to meningiomas. In order to assess the current prognosis of HMP we reviewed our personal experience limited to the last decade (1986-1995): during this period 7 patients (4M, 3F) were treated by surgery alone or surgery combined with postoperative radiotherapy. In spite of meticulous attempts at radical resection, the tumors recurred in all but two cases with a mean interval of 85 months, and a total of 18 operations were performed (2.57/patient; range 1-4). Massive intratumoral hemorrhage determined acute deterioration and required emergency surgery in two cases while in one patient diffuse visceral metastases were discovered at autopsy. Five patients are still alive at follow-up but only 2 of them are in good neurological conditions and without evidence of disease. These results are similar to those reported in other series. In view of our results we conclude that intracranial hemangiopericytomas still have a dismal prognosis. Advances in neuroimaging, neuroanesthesia, microneurosurgery and adjuvant therapy do not seem to have significantly affected the recurrence rate, quality of life and mortality.

Adult↗
PubMedDate not supplied

[Colloid cysts in the 3rd ventricle: a microsurgical series and new perspectives].

Colloid cysts are rare benign CNS lesions (0.5-2% of tumors), mostly located within the third ventricle. Although sometimes asymptomatic they may cause life-threatening complications and sudden death and therefore require active treatment in the vast majority of cases. Microsurgical removal warrants excellent radicality at low morbidity/mortality rates but emerging neuroendoscopic techniques have been applied successfully worldwide although longer follow-up of these patients is needed. We present out personal microsurgical series from last decade and discuss the results in the light of current knowledge and preliminary neuroendoscopic experiences.

Brain Diseases↗