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F Celada

Publications and source records attributed to F Celada.

81 records · Page 5Linked to original sources
PubMed1967

Quantitative studies of the adoptive immunological memory in mice. II. Linear transmission of cellular memory.

A calibrated cell transfer system allows detection of the anamnestic response to albumin without interference from the host's immune machinery; it was used to study the immunological memory of mouse spleen cell populations. The secondary antibody-forming capacity of the transferred cells was measured by challenging them at periods up to 6 months after transfer. The peak levels attained show a declining pattern in two phases: during the first month with a half-life of 15 days; thereafter, with a half-life of 100 days. The corresponding half-lives of the cellular memory are 26 and 190 days. In the light of these and of radioinactivation data, immunological memory is defined as the persistence of a specifically determined stem cell line, along which the information necessary to give rise to an antibody-forming cell population is transmitted from mother to daughter cells.

Animals↗
PubMed1966

Quantitative studies of the adoptive immunological memory in mice. I. An age-dependent barrier to syngeneic transplantation.

Antibody-forming cells suspended from a mouse spleen and transferred to intact animals of the same genotype face a barrier which severely affects their capacity to implant and/or to function. This phenomenon was quantitatively studied in a model system which, utilizing the immunogenic properties of human serum albumin in mice, allows the secondary response of the transferred cells to be followed without interference from the host's own reactivity. The barrier to syngeneic transplantation was found (a) to be radiosensitive (500 R X-rays to the recipient abolishes it and insures optimal functional conditions to the donor cells) in the same order of magnitude of other mammalian systems involving rapidly dividing cell populations, and (b) to depend upon the age of the recipient: its linear rise is documented from birth time (when approximately 50% of the maximal immune capacity of the transfer is expressed) to the age of 2 months ( approximately 1 %). The significance of these findings to the immune response and to cell growth and differentiation is discussed.

Animals↗