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Biomedical subjects

F Capasso

Publications and source records attributed to F Capasso.

At least 127 records · Page 7Linked to original sources
PubMed1984

Phenolphthalein stimulates the formation of histamine, 5-hydroxytryptamine and prostaglandin-like material by rat jejunum, ileum and colon.

The effects of phenolphthalein on the formation of histamine, 5-hydroxytryptamine(5-HT) and prostaglandin-like material by rat intestine were examined in vivo. Phenolphthalein, in a dose that causes laxation increased the formation of histamine, 5-HT and prostaglandin-like material, and indomethacin reduced these increases. The data support the idea that the laxative effect of phenolphthalein is due to increased intestinal production of prostaglandin, histamine and 5-HT.

Animals↗
PubMed1984

Influence of ricinoleic acid on the contractions elicited by PGE2 on the guinea-pig ileum.

The effect of ricinoleic acid on prostaglandin E2 (PGE2)-evoked contractions was studied on guinea-pig isolated ileum. Addition of ricinoleic acid (10 micrograms ml-1) to the organ bath increased the amplitude of the PGE2-evoked responses. Ricinoleic acid (10 micrograms ml-1) also sensitized the guinea-pig isolated ileum to acetylcholine and histamine. The effect of the ricinoleic acid was greatly reduced by indomethacin either in-vivo (10 mg ml-1) or in-vitro (2 micrograms ml-1).

Animals↗
PubMed1984

Suppression of laxative action of phenolphthalein by orally-administered indomethacin or aspirin.

Oral administration of phenolphthalein produced a dose-dependent increase of wet faeces excreted by mice. The response to phenolphthalein was reduced by pretreatment with indomethacin, aspirin or polyphloretin phosphate (PPP), but not with benoxaprofen. These findings support the view that the effect of phenolphthalein may be suppressed by PG synthetase inhibitors (indomethacin, aspirin) and by PPP.

Administration, Oral↗
PubMed1983

Chemical composition and anti-inflammatory activity of an alcoholic extract of Teucrium polium L.

In the Teucrium polium L. were identified, by gaschromatographic and spectroscopic techniques (1H-NMR and MS), beta-sitosterol, stigmasterol, campesterol, brassicasterol and clerosterol. In the aqueous phase of the alcoholic extract were identified glucose, fructose, raffinose and rhamnose by PC on Watmann paper Number 5. Anti-inflammatory activity was tested using male Wistar rats against carrageenin-induced paw oedema. All tested extract shown a sufficient pharmacological activity compared to that of indomethacine.

Animals↗
PubMed1983

Phytotherapeutic profile of some plants used in folk medicine.

The effect of nine vegetable extracts was evaluated on the carrageenin-induced oedema in the rat. Our results show that the above extracts are able to exert - at different degree - a very marked decrease of the inflammed site related to the presence in the considered plants of several active biologically compounds as sterols and flavonoids. Preliminary chemical analysis of these vegetables are also reported.

Animals↗
PubMed1983

Effect of indomethacin on aloin and 1,8 dioxianthraquinone-induced production of prostaglandins in rat isolated colon.

The effect of aloin and 1,8 dioxyanthraquinone on the release of prostaglandin-like material (PG) from rat isolated colon has been investigated. Orally administered aloin and 1,8 dioxyanthraquinone stimulates PG production by subsequently isolated segments of colon. Indomethacin was able to prevent this increased production of PG. These results suggest that the laxative properties of aloin and 1,8 dioxyanthraquinone may depend, at least in part, on increased prostaglandin synthesis by the intestinal tissue.

Administration, Oral↗
PubMed1982

Enhancement by levamisole of the contractions induced by prostaglandin E2 in the guinea-pig isolated ileum.

The effect of levamisole on prostaglandin E2 (PGE2)-evoked contractions was studied on guinea-pig isolated ileum. Addition of levamisole (10 micrograms/ml) to the organ bath produced a pronounced increase in the amplitude of the PGE2-evoked responses. Levamisole (10 micrograms/ml) also sensitized the guinea-pig isolated ileum to 5-hydroxytryptamine and bradykinin, but not to histamine. The effect of the levamisole was not due to stimulation of autonomic ganglia or cholinergic activity since it was unaffected by hexamethonium or atropine, but it was prevented by indomethacin.

Animals↗
PubMed1981

Some pharmacological properties of tiopronin.

Tiopronin (50 mg/kg) and D-penicillamine (50 mg/kg) do not exhibit anti-inflammatory effects in classic animal models (carragenin oedema, granuloma cotton pellets) but suppress pertussis vaccine oedema, an immunological model, when given with a long-lasting dosing regime. Tiopronin and D-penicillamine also fail to inhibit PG release by phagocytosing leucocytes when the concentrations used were in the same range as human blood levels (5-15 micrograms/ml). Indomethacin (1, 3 and 5 mg/kg) instead significantly inhibits both the in vivo and in vitro models considered. This may imply a different mode of action of both tiopronin and D-penicillamine from indomethacin. Tiopronin also possesses similar effects to D-penicillamine suggesting that their overall anti-rheumatic action may have common elements.

Amino Acids, Sulfur↗
PubMed1980

Endogenous inhibitor of prostaglandin biosynthesis in inflammation.

Rat serum exhibits a concentration-related inhibition of PG biosynthesis by rat peritoneal leucocytes phagocytosing killed bacteria. The serum inhibitory potency is increased by inducing carrageenan foot oedema in animals whereas it is not altered by dextran oedema. The increase of the inhibitory activity of serum from carrageenan-treated rats develops in a time-dependent way reaching its maximum at 24 h. Since the increased inhibitory activity does not occur following indomethacin administration we suggest that PG formation at the inflammatory site may stimulate the ability of serum to inhibit PG biosynthesis.

Animals↗
PubMed1977

Anti-inflammatory properties of griseofulvin.

Anti-inflammatory activity of griseofulvin has been investigated in comparison with indomethacin and flufenamic acid. In vitro, griseofulvin has been proved the most effective of these agents in suppressing the contractions of smooth muscle preparations induced by a variety of proposed mediators of inflammation, i.e. histamine, 5-hydroxy-tryptamine, bradykinin and prostaglandin E2. In vivo, griseofulvin was unable to modify dextran oedema but suppressed carrageenin oedema, although its activity was poor when compared to that exhibited by indomethacin and flufenamic acid. When tested in rat pleurisy induced by dextran or homologous serum griseofulvin was able to prevent polymorph migration into the pleural space while mononuclears remained virtually unaffected. In contrast indomethacin and flufenamic acid mainly suppressed mononuclear migration while polymorphs resulted only slightly affected. Similar results have been exhibited by the drugs when tested on mononuclear turnover in pleural cavities from normal rats. Results are discussed in the light of the clinically established ability of griseofulvin to prevent cutaneous inflammatory reactions as well as of its effectiveness in the treatment of several polyarthritic syndromes.

Animals↗