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Biomedical subjects

F Cano

Publications and source records attributed to F Cano.

At least 55 records · Page 3Linked to original sources
PubMed1990

Adenovirus types 40 and 41 and rotaviruses associated with diarrhea in children from Guatemala.

From March 1987 to February 1988, fecal excretion of adenovirus types 40 and 41 and rotavirus serotypes in 194 children (age, 0 to 3 years) from a rural community of Guatemala was monitored. In total, 458 samples taken during 385 episodes of diarrhea and 191 specimens obtained during symptom-free periods were examined by enzyme-linked immunosorbent assay. Fifty-seven children hospitalized because of diarrhea were also studied. Among the rural children, 43 (22.2%) excreted adenovirus types 40 and 41 and 20 (10.3%) shed rotaviruses. Adenovirus types 40 and 41 were associated with 54 (14.0%) illnesses, and rotaviruses were associated with 18 (4.7%) illnesses. Asymptomatic infections with adenovirus types 40 and 41 were documented in nine children and with rotaviruses in two children. Fifteen typeable rotaviruses were identified as serotype 2. In the hospital population, 36 (63.2%) children had viral infections. Rotaviruses were identified in 29 (50.9%) and adenovirus types 40 and 41 were identified in 15 (31.2%) of 48 subjects tested. Dual infections by these viruses were found in eight children. Of 22 typeable strains of rotaviruses, 9 (34.6%) were serotype 1, 12 (46.1%) were serotype 2, and 1 (3.8%) was serotype 3. All the children infected with serotype 2 rotavirus were coinfected with other enteric pathogens, while only three (37.5%) of those infected with rotavirus serotype 1 excreted another pathogen. Adenovirus types 40 and 41 are an important cause of gastroenteritis in both ambulatory and hospitalized Guatemalan children. There seems to be a difference in the pathogenicity among rotavirus serotypes.

Adenoviridae Infections↗
PubMed1989

[Acute and persistent diarrheal disease and its nutritional consequences in Guatemalan infants].

For the purpose of better understanding the epidemiology of acute and persistent diarrhea, 130 infants of a marginal urban area in Guatemala City were studied. The subjects were kept under surveillance by weekly home visits, for periods that varied from three to nine months. The diarrhea episodes were detected and microbiological studies were done in fecal material. Additionally, the children were weighed and measured to determine their nutritional status. The infants suffered, on the average, 5.2 episodes per child annually; 9.4% of all the episodes lasted at least two weeks. The children who were less than six months old had more episodes of persistent diarrhea (0.052/child-month) than the older ones (0.017/child-month), with previous diarrhea morbidity and number of infecting enteropathogens being important factors. Furthermore, a child who had already suffered an episode of persistent diarrhea had a higher probability (relative risk = 2.2) of developing an additional one. Adherent E. coli, Cryptosporidium, toxigenic E. coli and Campylobacter jejuni are the pathogens more commonly associated with persistent diarrhea. Diarrheal illnesses have a deleterious effect on nutritional status, especially persistent episodes, which interfere with gain in weight and length of the children.

Acute Disease↗
PubMed1989

[Hemodialysis and urea kinetics. An elementary computational program].

An elementary computational program to optimize dialysis in children with chronic renal failure was developed. The program is based on the urea kinetics model. Parameters involved in the efficiency of hemodialysis such as time and clearance, hemofilter performance and body surface area, as well as nutritional needs of the child are considered in the program.

Child↗
PubMed1988

Sabin inactivated trivalent poliovirus vaccine: first clinical trial and seroimmunity survey.

The most widely used poliovaccine in the United States contains the three live attenuated strains originally produced by Sabin. An inactivated ("killed") formulation of this trivalent polio vaccine has now been prepared. Before testing this new vaccine, we assessed the poliovirus immune status of 39 healthy adult males between the ages of 20 and 44 years and found that 69% had detectable (titer greater than or equal to 1:4) neutralizing antibody to all three types of poliovirus, whereas 31% lacked antibody to 1 or more types even though they had a history of childhood polio immunization. Of interest, the lowest levels of neutralizing antibody were found among young adults in their late 20s, 2 of whom lacked antibody to all 3 polio types. When the Sabin inactivated trivalent poliovirus vaccine was initially administered to 12 seropositive volunteers, all responded with rising titers of neutralizing antibody that persisted for at least 18 months (range, 1:249 to 1:4948). The new vaccine was also given to a second group of 9 individuals with little or no detectable neutralizing antibody to at least one poliovirus type and again all vaccinees manifested a humoral immune response to poliovirus. Except for transient local tenderness at the injection site, no untoward reactions to immunization were observed. Thus, this Phase I study (1) confirmed earlier reports that titers of poliovirus antibody may decline to undetectable levels by early adulthood and (2) demonstrated that adults previously immunized with poliovirus vaccine responded rapidly to all 3 poliovirus types (within 7 days) upon reimmunization with Sabin inactivated trivalent vaccine whether or not there was preexisting detectable antibody.

Adult↗
PubMed1988

Breast milk anti-Escherichia coli heat-labile toxin IgA antibodies protect against toxin-induced infantile diarrhea.

A prospective study to assess whether milk IgA antibodies against Escherichia coli heat labile-toxin protect breast-fed children against labile toxin-induced gastroenteritis was carried out among infants of a marginal urban area in Guatemala. One hundred and thirty children were kept under surveillance for diarrhea by periodic home visits. Stool specimens were collected from each child routinely every 2-3 weeks and during diarrheal episodes, to study the excretion of labile toxin-producing Escherichia coli. Milk samples from the children's mothers were obtained concomitantly with the fecal specimens of the infants to be analyzed for anti-labile toxin antibodies. Twenty infections by heat-labile toxin-producing Escherichia coli as a sole agent were documented among breast-fed infants. Nine of these infections resulted in gastroenteritis, while the remaining 11 were asymptomatic. At the time of infection children who became sick were ingesting breast milk with significantly (p = 0.028) lower titers of antilabile toxin IgA than those who remained healthy. Only one of the 8 infected children receiving breast milk with high titers (greater than or equal to 256) of anti labile toxin IgA developed diarrhea, compared to 8 of the 12 subjects being fed milk with low titers (less than or equal to 64) (p = 0.025). This is the first report documenting protection by IgA antibodies in milk against labile toxin-induced gastroenteritis in infected breast-fed infants.

Bacterial Toxins↗
PubMed1988

Infection and diarrhea caused by Cryptosporidium sp. among Guatemalan infants.

During July 1985 to June 1986, fecal excretion of Cryptosporidium oocysts was determined prospectively in a cohort of 130 infants, aged 0 to 11 months, living in a marginal urban area of Guatemala City, Guatemala. A total of 1,280 stool specimens were examined; 158 of them were collected during episodes of diarrhea, and 1,122 were collected during symptom-free periods, every 2 to 3 weeks, from every child. Of the children, 20 (15.4%) excreted Cryptosporidium oocysts during the observation period. Of the diarrheal episodes, 13 (8.3%) were associated with Cryptosporidium sp. Of the control specimens, seven (0.6%) were positive for oocysts. Most of the infections were documented during the months of February to May, at the end of the dry season. Cryptosporidium infections are very common among Guatemalan infants and are an important cause of diarrhea and weight loss. The introduction of liquid or solid foods in the diets of the children, the presence of domestic animals (dogs, cats, or poultry), and the absence of toilet facilities in the house seem to be important risk factors for infection; also, deficient nutritional status may predispose the infected child to Cryptosporidium-associated illness.

Age Factors↗
PubMed1987

Multiple sclerosis and Hashimoto's thyroiditis.

A case of multiple sclerosis and Hashimoto's thyroiditis confirmed by cytology is reported. The association of multiple sclerosis with other autoimmune diseases is infrequent but supports the immune hypothesis of the pathogenesis of multiple sclerosis. The authors suggest the inclusion of immunological tests in the screening of all patients diagnosed as having multiple sclerosis.

Adult↗
PubMed1982

Hepatic acetylator phenotype in diabetes mellitus.

Hepatic acetylator phenotype was determined using the sulphamethazine method in 32 patients with juvenile-onset diabetes mellitus and in 87 patients with the maturity-onset diabetes mellitus (Types I and II) and among 157 controls. No statistical differences were observed, neither for the incidence of acetylator phenotype among diabetics as compared with the control group, nor for the age at diagnosis of maturity-onset diabetes in slow and rapid acetylators. The incidence of diabetic retinopathy was similar among both phenotypes.

Acetylation↗
PubMed1980

[Cerebral tuberculoma: an atypical case (author's transl)].

A case is reported of a 72 year-old female patient with multiple cerebral tuberculomas and a clinical course of 11 months that was characterized by personality changes, disorientation and progressive mental obtundation. The patient had a fatal outcome in spite of ventricular drainage and antituberculous therapy. Postmortem examination disclosed small tuberculomas in the cerebellum and brain stem, as well as residual tuberculous lesions in the upper lobe of the right lung. The clinical interest of this case lies in the old age of the patient, the rarity of the disease in western countries, and the location of tuberculomas in the brain stem with associated tuberculous meningitis. The higher incidence of cerebral tuberculomas in eastern and african countries is commented upon, and its anatomical, clinical, diagnostic and therapeutic features are reviewed. Finally, the two existing pathological forms and their respective clinical and therapeutic peculiarities are analyzed.

Aged↗