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Biomedical subjects

F C Rose

Publications and source records attributed to F C Rose.

At least 73 records · Page 4Linked to original sources
PubMed1985

Problems in the management of stroke.

Cerebral vascular accidents are the third commonest cause of death in the western world, after heart disease and cancer. Although they occur at any age, the risk greatly increases as we get older and, as life expectancy is increasing in all countries, cerebral vascular accidents are becoming commoner. In addition to being a major cause of death, stroke is the single most common cause of chronic disability, the care of which requires considerable financial resources, both to the individual patient, who suffers loss of earning power, to his family, and to the state. This paper reviews the many different drugs that are used in stroke and points out their advantages and disadvantages.

Anticoagulants↗
PubMed1984

Elevated levels of amino acids in the CSF of motor neuron disease patients.

Amino acid levels in the cerebrospinal fluid of patients with motor neuron disease were compared with an age-matched control group receiving diagnostic myelography. Five amino acids were significantly elevated in the cerebrospinal fluid of the motor neuron disease patients compared to the controls. These were isoleucine, glycine, alanine, phenylalanine, and threonine, which were increased by 60, 58, 38, 26, and 25% respectively. A significant increase was also obtained when the amino acids with nonpolar R groups were grouped together (34%). The significance of these findings is discussed in terms of amino acid changes that occur in both normal aging and other neurological conditions.

Adult↗
PubMed1984

Involvement of head movement in speech production and its implications for language pathology.

Analysis of head movement during speech, monitored by the polarized light goniometer, showed that head movement accompanies speech almost continuously in a manner specific to the concomitant, suprasegmental speech features. Thus initiation of speech after long pauses was accompanied by wide, linear movements (PS). The termination of speech in a pause (terminal juncture) was accompanied by movements of medium amplitudes and frequencies (OM). Sharp, intense movements (RM) were indicative of a peak in loudness, and often of a major phonetic stress. Finally, a speech disturbance was accompanied by movement if it involved a sharp prosodic transition. We suggest that these correlations indicate that head movement may have a role in speech production, regulating the many degrees of freedom and the dissipation of energy in speech. Furthermore, head movements may play a role in linguistic processing through the generative functions of stress, prominence, and orienting responses. Implications for speech pathology, especially dysphasia, are discussed.

Aphasia↗
PubMed1983

[Development of a neurological score for the clinical evaluation of sylvian infarctions].

Among the main methodological problems raised by clinical trials in cerebral vascular accidents, one of the most serious is the lack of well-established and widely accepted criteria to evaluate the course of the disease. On the basis of published scores and of several trials carried on by us in three different centres during the last few years, we have developed a neurological score devised to reflect, as accurately as possible, deficits due to infarctions in the Sylvian territory, yet rapid and simple enough to provide an objective and reproducible rating. We report here the results of a prospective study concerning the inter-rater variations of the score from one centre to the other (inter-centre study) and within each centre (intra-centre study). These results have led us to withdraw three items with insufficient response rate and poor agreement, viz, "mental confusion", "visual field" and "sensory disorders". With the remaining 10 items the mean agreement between individual items varied from 85% to 90% and the global score agreement exceeded 90%. A study comparing our score with the Barthel index showed close correlation up to the autonomy threshold (Barthel index = 60) and divergent results beyond that point. The good agreement observed between inter-rater variations suggests that the score is reliable but does not inform on its sensitivity. In view of their relative independence, the neurological and the functional score should be regarded as complementary and should be used together as criteria of clinical assessment.

Aged↗
PubMed1983

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Anxiety↗
PubMed1983

Double blind comparison of mefenamic acid and acetaminophen (paracetamol) in migraine.

We have assessed the role of mefenamic acid, a non-steroidal anti-inflammatory drug known to inhibit both the synthesis and actions of prostaglandins, as an analgesic in migraine by comparing it with the established analgesic paracetamol (acetaminophen) in a double-blind cross-over trial. Forty ambulant migraine patients were supplied with oral medication for six consecutive attacks; metoclopramide 10 mg was administered in all attacks, and paracetamol 500 mg and mefenamic acid 500 mg for three attacks each. The patients recorded the intensity of the headache at the time the medication was taken, and again after 3 hours, on a linear analogue scale. Twenty-two patients completed the trial satisfactorily. Seven had insufficient attacks and the remainder were lost to follow-up. The mean reduction in headache intensity was 36 +/- 11% on mefenamic acid and 27 +/- 10% (both mean +/- SEM) on paracetamol. While this difference is not quite statistically significant (0.1 greater than P greater than 0.05) there still remains a 28% probability that mefenamic acid is twice as potent as an analgesic. The responses in each individual patient to the two drugs were very closely correlated (P much less than 0.001). Our failure to demonstrate a convincing difference between the two analgesics leads us to speculate that peripheral prostaglandin mediated pain pathways, in which paracetamol is inactive, may be less important than central pathways, which are inhibited by both drugs.

Acetaminophen↗
PubMed1983

Migraine: definition and classification.

There are an enormous number of terms and classifications used in the field of headache and migraine. There is little general agreement and the situation is not helped by the introduction of new terminologies. An approach is suggested to overcome this problem based on the clinical characteristics of the patient. Until there are more definite markers of the different types of headaches, e.g. biochemical, physiological or pharmacological, this should obviate the need for yet further neurological debate.

Female↗
PubMed1983

Antecedent events in motor neuron disease.

Sixty-three patients with motor neuron disease and sixty-one controls matched for age and sex were interviewed concerning life events. An antecedent history of back injuries was found more often and there was an increased incidence of prior electric shock amongst the patients. No increase of head injuries, fractures, malignancy or previous poliomyelitis was detected.

Craniocerebral Trauma↗