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Biomedical subjects

F C Hugues

Publications and source records attributed to F C Hugues.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

[Drug-induced respiratory disorders].

Drugs induced respiratory disorders include bronchospasm, extrinsic alveolitis, and diffuse interstitial pulmonary fibrosis. Bronchospasm may be due to the action of pharmacodynamic agents on autonomic control of bronchial tone (beta-blockers, beta-agonists...) or to a hypersensitivity reaction (penicillins, sulfonamides, anti-inflammatory compounds...). Extrinsic alveolitis usually follows administration of anti-infective medication but other drugs may be implicated. Prolonged use of a wide variety of drugs, particularly cytotoxic agents, is necessary to provoke the onset of a diffuse interstitial pulmonary fibrosis.

Adrenergic alpha-Agonists↗
PubMedDate not supplied

[The unusual origin of an acute cephalalgia, a colloid cyst of the third ventricle (author's transl)].

An unusual acute cephalalgia might reveal a vascular or tumoral cerebral disease. The authors report a case of cephalalgia of such a type following upon a colloid cyst of the third ventricle, an exceptional but serious cause, whose symptomatology they are discussing; in this connection, they are studying the problems concerning three other cases of acute cephalalgia. In these four patients, cephalalgia is almost the only symptom. A recent unique relapsing acute cephalalgia, without appreciable previous history, should induce to perform thorough paraclinical investigations and, above all at present, a tomodensitometric test.

Adolescent↗
PubMedDate not supplied

[Management of hypo-uricemia (author's transl)].

Hypo-uricemia (under 120 mumol/L) is not uncommon (1% of the population). Two main mechanisms are responsible (abnormal synthesis and anomalies in renal excretion), but there are a great number of possible etiologies. Except for states of stress or distress (30%), etiology focuses on drugs (60%), mainly aspirin. Malignant disease, particularly myeloma and broncho-pulmonary carcinoma which can be revealed by hypo-uricemia, are much less frequent. Genetically determined cases are uncommon. The diagnostic approach for finding the etiology should be physiopathological and focused on a simple test : uric acid clearance.

Humans↗
PubMedDate not supplied

[Polyresistance of asiatic P. falciparum to chloroquine and pyrimethamine-sulfadoxine combination. Apropos of a new case].

The authors report a case of a multi-drug resistant Asiatic P. falciparum strain in a first non-immune man treated out of an endemic zone after failure of chemoprophylaxis by pyrimethamine-sulfadoxine. The authors compare this care with the lately published cases in Germany and Switzerland. They call again that I and II resistances were observed at the time of the drug's trials in and out of endemic zones. They ascertain that this resistances are often associated with chloroquino-resistance and that their number increases chiefly in certain areas.

Adult↗
PubMedDate not supplied

[Drug interactions and the elderly].

Elderly people are particularly at risk for drug interactions, for several reasons. They are the part of the population who consume the most drugs: over 75 years the mean number of drugs on a prescription is 5.6. As they suffer from various associated diseases, they see several medical specialists, each of them adding a new prescription to the others. Self-prescriptions complicate the problem because they are rarely mentioned. Changes in pharmacokinetics in the elderly tend to increase blood concentrations of drugs. Elderly people suffer from altered homeostatic mechanisms to compensate for adverse drug effects. As a whole, such individuals are more exposed to the side effects of drugs. The drugs most often involved in these interactions are diuretics, non-steroidal anti-inflammatory drugs, benzodiazepines, antiarrhythmics, cardiac glycosides, antihypertensive drugs, oral antidiabetics and antalgics. The clinical accidents most often occurring with these drug interactions are: malaise, orthostatic hypotension, loss of conciousness, amnesia, confusion, renal insufficiency, digestive problems. Since elderly people are less likely to recover easily, this problem of drug interaction should be looked for systematically.

Age Factors↗
PubMedDate not supplied

[Evaluation of the gastrotoxicity of anti-inflammatory drugs: contribution of general registries of digestive endoscopy].

The evaluation of the rate of gastroduodenal toxicity of anti inflammatory drugs is a difficult problem. We tried to analyse that question by studying the general endoscopic registers of the Gastro-Enterologic department of the hospital. This retrospective study concerns 2,945 endoscopies performed during the year 1988 and 1992 randomly chosen among the last 5 years. 992 results show injuries suggestive of non steroidal anti inflammatory drugs (NSAID) toxicity, however only in 65 cases the potential role of an anti inflammatory drug is mentioned: 36 men and 29 women, mean age: 50.6 +/- 19.6 years. Concerning the drugs, only the pharmacological classes they belong to are mentioned except for Aspirin. Acetyl salicylate acid 7 cases, NSAIDS 36 and Steroids 22. In the drug group 63% of injuries are located to the stomach (ulcers 13%, gastritis 50%), 37% to the duodenum (19% ulcers, 18% duodenitis). Compared to the groups with the same kind of injuries, but without any mention of drugs, there are no statistical difference in the proportion of ulcers. Aging and sex are not influent in our results on the genesis of drug induced ulcers. These results must be discussed because a lot of datas are missing in the registers and so the number of patients taking drugs is probably underestimated. This means that unless a prospective study is held with someone enquiring for all the risk factors, the study of the general endoscopic registers is not a good way to estimate gastrointestinal damages due to drugs.

Adult↗
PubMedDate not supplied

[Homonymy of drugs: a cause of prescription and dispensing errors].

There have been recently a prescription error and a dispensing error in our department due to drug names which look or sound alike. Errors of this type have frequently been quoted in the Anglo-Saxon literature. The method of choosing a drug trade name is recalled, and a table of French drug names which can involve errors of prescription and dispensing errors is provided.

Adult↗