Simultaneous hemodynamic and equilibrium radionuclide function measurements were performed at rest and during exercise before and 75 min after oral administration of 30 mg bufuralol, a nonselective beta-adrenoceptor blocking drug, in 10 patients with stable angina pectoris. Acute beta-blockade with bufuralol resulted in a reduction of exercise-stimulated heart rate, Systolic blood pressure, and cardiac index. There was, however, also a fall in diastolic blood pressure and end-diastolic volume index, and an improved global left ventricular ejection fraction, without a change in total vascular resistance, suggesting an acute vasodilator effect. regional analysis revealed that this beneficial effect was particularly present in ischemic segments of the left ventricular wall where regional function increased. Thus, bufuralol is a beta-adrenoceptor blocking agent with additional peripheral vasodilating properties.

Adrenergic beta-Antagonists↗

PubMedDate not supplied

Acute hemodynamic effects of bisoprolol, a new beta 1 selective adrenoreceptor blocking agent, in patients with coronary artery disease.

To assess acute hemodynamic effects of the new beta-adrenergic blocking drug bisoprolol with experimentally documented beta 1 selectivity, we studied 16 patients with stable angina and angiographically proven coronary artery disease. Simultaneous right heart catheterization and radionuclide angiocardiography were performed at rest and during exercise without treatment (control) and 2 h after 5 mg bisoprolol (6 patients) and 20 mg bisoprolol (10 patients), respectively, administered perorally. The hemodynamic profile of bisoprolol was similar to that previously described after acute beta-blockade. A negative chronotropic effect occurred after 5 mg bisoprolol at rest, but the negative inotropic changes did not reach significance, whereas cardiac index decreased and total vascular resistance increased after 20 mg bisoprolol. During exercise, negative inotropic and blood-pressure-lowering effects were present after both dosages, resulting in improved myocardial oxygen consumption as reflected by a significantly reduced rate pressure product. Because ejection fraction and pulmonary capillary wedge pressure were not significantly changed even after the 20 mg dose, bisoprolol has only mild negative inotropic effects and seems hemodynamically safe.

Adrenergic beta-Antagonists↗