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Biomedical subjects

F Braun

Publications and source records attributed to F Braun.

At least 109 records · Page 6Linked to original sources
PubMed1979

[The significance of respiratory syncytial virus as pathogen in respiratory tract infections in infants (author's transl)].

Ten out of twenty babies aged up to twelve months and admitted during the months February and March 1978 were shown to be infected with Respiratory Syncytial Virus. During the first 6 months of life the disease usually presents as bronchiolitis. Serologically only neutralising antibodies were demonstrable in this age group. IgA was usually raised in babies with bronchopneumonia. An allergic reaction between virus antigen and maternal antibodies is considered to occur, assuming an activation of the infant's own secretory immunoglobulin.

Antibodies, Viral↗
PubMed1979

[Autologous cancellous bone grafting in rabbits using a fibrinogen adhesive system (author's transl)].

The changes in remodelling of autologous cancellous bone after reimplantation using a fibrinogen adhesive system (FAS) consisting of highly concentrated fibrinogen, thrombin and factor XIII were investigated in 23 rabbits. A 5 x 6 mm sized piece of bone was removed from the iliac crest and reimplanted in the same place with and without FAS. Histological, tetracycline fluorescence and radiological evaluation were carried out after 3, 6 and 9 weeks. The control group (without FAS) showed considerable breakdown of the bony trabeculae due to regression of the osteocytes in the centre of the reimplanted bone after 3 weeks, whereas in the FAS group bone was being built on to the vital trabeculae. After 6 weeks the reimplant in the FAS group was still clearly advanced in relation to the non-FAS group. The difference had almost disappeared after 9 weeks. Acceleration of remodelling and lack of regression of the osteocytes in the centre of autologous reimplants after the use of FAS indicates an earlier recommencement of nutrition as compared with the control group. New bone formation in autologous reimplants was clearly accelerated by the use of FAS.

Animals↗
PubMed1979

[Reaction of connective tissue and striated muscle tissue to implanted ashwood (author's transl)].

In former experiments it could be shown, that new bone is formed around ashwood after implantation in the tibia of rabbits, in spite of a foreign-body tissue reaction. Equally prepared ashwood half-cylinders were now implanted in the soft tissue of rats and evaluated 2, 6, 12 and 30 weeks after implantation. Around the implants a foreign-body tissue reaction developed and demonstrates the hitherto insufficient preparation of the implants.

Animals↗
PubMed1979

[Inhibition of secondary increase of intraocular pressure following cyclokryocoagulation (author's transl)].

Prostaglandin mediated transient increase in intraocular pressure following cryokoagulation of the ciliary body in rabbits was completely inhibited by preoperative administration of Aspisol (D, L-Lysin-mono-(acetylsalicylat)). To avoid additional increase in intraocular pressure in patients chosen for cyclocryotherapy, pretreatment with Aspisol could prove to be effective.

Animals↗
PubMed1978

Semisynthetic cephalosporins. Synthesis and structure-activity relationships of 7-(1-pyrryl)- and 7-(1-indolyl)acetamidocephalosporin derivatives.

A series of 1-pyrrole- and 1-indoleacetamido derivatives of 3-heteroaryl-substituted cephalosporins was prepared. The most active compound in the series was 7-[[2-(1-pyrryl)acetyl]amino]-3-[[(1-methyltetrazol-5-yl)thio]-methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6), which showed comparable potency in vitro and in vivo to that of cefazolin, and, in addition, was more potent than cefazolin against Enterobacter sp. and Providencia stuartii.

Animals↗
PubMed1977

[The technic of fibrin glue in cancellous bone transplants (author's transl)].

The paper deals with the clinical experience in the use of a biological adhesive system in conjunction with bone transplants to close large bone defects. The gluing technique has been exactly described, 11 patients with a follow-up between 9 and 21 months are being presented. The application of this system which consists of highly concentrated native fibronogen, thrombin, and clotting factor XIII results in an acceleration of homogenous incorporation of the implants. No deterioration of wound healing occurred. The advantages of this method are: exact local hemostasis, adhesive strength, and plasticity.

Adult↗
PubMed1977

[Long-time follow-up of rare liver tumours in infancy (author's transl)].

Two rarely-observed tumours of the liver are discussed: firstly, primary liver carcinoma in a 5-month-old infant, and secondly, myxoma in a newborn infant. Both tumours were removed surgically. The child with primary liver cell carcinoma was treated for 2 1/2 years with cyclophosphamide. She has been followed-up for 8 years and can be assumed to be cured. Both children developed normally. The pathogenesis of liver tumours at this early age is discussed.

Carcinoma, Hepatocellular↗
PubMed1977

[The action of high-concentrated fibria on bone healing (author's transl)].

The influence of a biological tissue glue--based on fibrinogen clotting--on bone healing has been investigated in animal experiments. Standardized cortical defects in the tibiae of rabbits were closed with a plug of homologous or heterologous fibrin. The course of restoration has been studied using histological techniques, x-ray examinations and isotopes (Ci 99 TC). Heterologous fibrin delays bone formation, due to a local immune response. Homologous fibrin on the other hand cubances and accelerates sprouting of capillary vessels and connective tissue cells which results in rapid new formation of bone.

Animals↗
PubMed1977

[Qualitative analysis of the binding of fibrin in organic tissue (author's transl)].

The binding energy (EB) of oxygen, sulphur and nitrogen was determined in highly concentrated fibrin, collagen, liver parenchyma and muscle tissue using photoelectron spectrometry. Fibrin was mixed with the collagen, liver or muscle homogenisate, with or without substitution of clotting factor XIII or additional inhibiton of fibrinolysis and the EB was determined again. Changes in the binding energy arise from an alteration in chemical binding. The present investigation showed that fibrin builds up new linkages in liver parenchyma and in collagen using nitrogen bonds and, additionally via a sulphur bond. After addition of fibrin stabilizing factor a new chemical link appeared between fibrin and collagen again through a nitrogen bond and, additionally via a sulphur bond. The inhibition of fibrinolysis produced a new oxygen linkage in all the examined substances (fibrin-tissue).

Binding Sites↗
PubMed1977

[Experiences with a biological adhesive system (fibrin) in the dressing of kidney parenchymal wounds (animal experiment and 1st clinical experiences)].

We report on investigations describing the use of a biological adhesive system for tissue adhesion and local haemostasis. This system consists of highly concentrated native fibrinogen and thrombin. Clotting factor XIII is admitted for reinforcement of the fibrin network. In experimental partial kidney resection this system was used with excellent results. This experience led to successful application of this method in 15 patients who underwent partial nephrectomy for various diseases.

Animals↗
PubMed1977

[Fibrin adhesion (orientating animal experiments) (author's transl)].

For some time fibrin adhesion is successfully used instead of sutures in different branches of surgery. We tested in animal experiments whether this method can be used for a sutureless closure of perforating corneal and corneoscleral wounds. Our results up to now do not show us any such possibility.

Animals↗
PubMed1976

[The effect of anti-inflammatory substances on free muscle transplants in the experimental animal (author's transl)].

The effect of repeated subcutaneous injections of hydrocortisone and phenylbutazone on connective tissue formation was investigated in free rat muscle transplants. The follow-up investigation took place 4 weeks after transplantation of the long extensor muscles of the digits to the vastus lateralis group of the rectus femoris muscle. Connective tissue measurements were performed on the basis of hydroxyproline determinations. It was observed that in the untreated transplant there is twice as much connective tissue (expressed as a percentage) as in the same muscle remaining in situ. Hydrocortisone did not reduce the amount of connective tissue in the transplant. Phenylbutazone reduced the amount of connective tissue by 27%. At the same time the total weight of the transplants treated with hydrocortisone and phynylbutazone was reduced by 15% and 33% respectively. Attention is drawn to the myotoxic properties of hydrocortisone and phenylbutazone. Hence, in spite of the inhibited connective tissue formation there is no improvement in muscle fibre regeneration and their use cannot be recommended.

Animals↗