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Biomedical subjects

F Brandrup

Publications and source records attributed to F Brandrup.

At least 109 records · Page 6Linked to original sources
PubMed1981

The prevalence of psoriasis in Denmark.

A representative random sample comprising approximately 4000 Danes, 16-99 years old, were questioned as to present or previous psoriasis eruption by non-medical, professional interviewers. Based on the information obtained, the point prevalence for men was 4.2%, for women 3.3%. 88% of those who believed themselves to be suffering from psoriasis stated that they had been treated by doctors for psoriasis and 71% by dermatologists and/or dermatological departments. The difference found between men and women is not statistically significant. The actual prevalence has been adjusted according to an estimated overcalculation of some 25% based on the number of false-positive answers to questionnaires in a twin study. The prevalence for men is thus adjusted to 3.2% and for women to 2.5%. The number of adult psoriatics in Denmark is estimated at approximately 113,000, of whom 71,000 suffer from mild psoriasis and 42,000 from more severe psoriasis.

Adolescent↗
PubMed1981

Relation of monocyte and neutrophil oxidative metabolism to skin and oral lesions in carriers of chronic granulomatous disease.

Out of fifteen carriers of X-linked chronic granulomatous disease five had discoid lupus erythematosus-like skin lesions together with recurrent aphthous-like stomatitis, another five had only recurrent aphthous-like stomatitis, and the remainder were symptom-free. In individual carriers monocytes and neutrophils were equally reduced in their capacity for superoxide production, [1-14C]glucose oxidation and antibody-dependent cytotoxicity; but within he group of carriers a broad spectrum of depression was found. The degree of depression was closely related to the manifestations of clinical disease. It is suggested that the defective oxygen-dependent metabolism might play an aetiological role in the development of inflammatory diseases in carriers of chronic granulomatous disease. Two out of 10 unselected females with discoid lupus erythematosus were shown to be carriers of X-linked chronic granulomatous disease. Screening for this carrier state might therefore be of importance in these patients.

Adult↗
PubMed1980

Localized polyartheritis nodosa in the lower limb with new bone formation.

A 61-year-old male patient, with a burned-out ankylosing spondylitis, developed polyarteritis in the right lower limb, associated with periosteal new bone formation in tibia and fibula. An acute exacerbation may have been precipitated by an infection with yersinia. HLA type: A 28, 26, B5, 27, Cwl.

Bone Development↗
PubMed1979

Nickel dermatitis provoked by buttons in blue jeans.

A total of 79 nickel-sensitive patients (65 women, 14 men) were examined with regard to a present or past eczema corresponding to contact with metallic buttons in blue jeans; 63% of the women and 64% of the men had or had had eczema of this kind. Among 40% of the women below 30 years this was the primary site of manifestation. The seriousness of this sensitivity is illustrated by the fact that two-thirds of the nickel sensitive patients with button dermatitis had or had had eczema of the hands. The conclusion is that blue jean buttons should be made of a material which does not contain nickel, for instance zinc alloys which are presently used for some metallic buttons, or they should be designed in such a way that the button does not directly contact the skin.

Adolescent↗
PubMed1979

[Infection in man and dog with the mite, Cheyletiella yasguri Smiley].

The infection with the mite Cheyletiella yasguri Smiley in 3 dogs and 5 out of 6 persons exposed to infestation is reported. Two of the dogs appeared to have been infected during a stay in a kennel. The dogs presented with moderate itching and slight to massive floury squamation on the back. In the infected persons, excoriated papules were present on the body and the extremities. The itching, which had persisted for 4--12 months, disappeared in all cases a few days after the dogs had been removed from the house. In the dogs, three antiparasitic baths were sufficient to exterminate the mite population.

Adult↗
PubMed1978

alpha1-Antitrypsin deficiency associated with persistent cutaneous vasculitis. Occurrence in a child with liver disease.

alpha1-Antitrypsin (alpha1-AT) deficiency is an autosomal recessive inherited disease. The serum concentration of the protease inhibitor (Pi) alpha1-AT is controlled by a set of codominant allelic genes, constituting the so-called Pi system. Abnormal conditions reported in connection with severe alpha1-AT deficiency of the PiZZ type have been, in the newborn, cholestasis and progressive juvenile cirrhosis, and in adults, panacinar pulmonary emphysema and liver disease. Skin changes have not been described previously in connection with this disease picture. The case is persistent cutaneous vasculitis in a 2-year-old child with alpha1-AT deficiency of the PiZZ type, heterozygosity for the Duarte variant of galactose-1-phosphate uridyl transferase, and neonatal liver disease. A pathogenetic relationship may exist between the biochemical defects and both the skin and liver diseases.

Child, Preschool↗
PubMed1978

Psoriasis in an unselected series of twins.

The relative importance of genetic factors in the origin, age at onset, clinical type, course, and severity of psoriasis was evaluated on the basis of an unbiased sample of twins, ie, the Danish Twin Register, which covers the total population of twins born in Denmark. All verified and probable cases of psoriasis in twins, born 1891 through 1920, were ascertained. Results are presented of an examination of all members of index pairs in which both partners were alive on a certain date. Fourteen monozygotic and 22 dizygotic, like-sexed pairs were found to include at least one partner with unquestionable psoriasis. Zygosity determination was mainly based on extensive serological examinations. The analyses show that the manifestation of psoriasis depends almost exclusively on the presence of the specific genotype. The age at onset, clinical type, course, and severity are also mainly determined by the genetic constitution. Association with certain HLA antigens of the B series has been confirmed, but the fact that many of the twins (including several of the concordant monozygotic pairs) possess neither of these antigens shows the corresponding genes to be important, but not decisive, elements in the predisposition. We conclude that psoriasis is a genetically determined disorder that may, to a limited extent, be modified by environmental influences.

Adolescent↗
PubMed1978

Axillary hyperhidrosis: local treatment with aluminum chloride hexahydrate 25% in absolute ethanol.

Eleven women (group I) with axillary hyperhidrosis were treated ad modum Shelley & Hurley with local application of aluminium chloride hexahydrate 25% in absolute ethanol and plastic foil occlusion during two successive nights once a week. The patients were observed for 24 weeks. Another 12 women (group II) were treated for up to 12 weeks with aluminium chloride hexahydrate 25% in absolute ethanol but without using plastic foil occlusion. We have attempted to determine the effect of the treatment by sweat measurements, leaving the left axilla untreated during the initial 1--2 weeks as a control. An immediate reduction in sweat production of the treated axilla was found in both groups. The reduction increased during the first weeks and was maintained thereafter. The degree of sweat reduction was the same during standardized work and during rest (group II). At the final controls all patients in group I had discontinued the occlusion and had individualized the treatment, most of them using local application 1--2 times weekly. Two patients in group I had to stop the treatment because of unbearable itching. The other patients found the treatment completely satisfactory. All patients had experienced itching and smarting when starting the treatment. Often these discomforts were temporary but they seem to require active support by close medical control during the initital period of treatment. In contrast to previous investigations, effective treatment was achieved both with and without occlusion.

Adolescent↗
PubMed1976

Lymphangioma circumscriptum of the tongue.

A case is reported of severe transient macroglossia after biopsy from the tongue in a 13-year-old boy who has had intermittent macroglossia since the age of 1 year as a result of extensive lymphangioma circumscriptum of the tongue. The acute lesions appear to result from haemorrhage into the lymphatic spaces following rupture of blood vessels in connective tissue septa and possibly secondary infection.

Acute Disease↗