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Biomedical subjects

F Boralevi

Publications and source records attributed to F Boralevi.

30 records · Page 2Linked to original sources

[Herpes simplex in children. Clinical manifestations, diagnostic value of clinical signs, clinical course].

Herpetic gingivostomatitis (HGS) is the predominant manifestation of cutaneomucosal herpes in children with HSV1 primary infection before the age of 3 years. The infection is self limiting and lasts 10 to 14 days. Pain and dysphagia are particularly important during the first week of infection and may necessitate parenteral rehydratation and administration of antalgesics. HGS in the young child causes substantial morbidity leading to hospital and social costs (work stoppage for parents). The clinical course is generally benign with the exception of forms with important extension, eczema, herpeticum Kaposi-Juliusberg pustulosis observed at this age only in children with atopic dermititis. Other severe forms are observed in the neonate and immunodepressed subject, which can also be caused by HSV1. Forms with little or not clinical manifestation predominate and generally go undiagnosed, explaining the asymptomatic viral excretion observed in the saliva or other secretions (ocular, genital secretions). Despite the sterotypic nature of the clinical expression, HGS is still often undiagnosed both by general practitioners and pediatricians. This lack of diagnosis generally has few consequences due to the benign course in a few days, but the infection can have an important psychological and social leading to significant healthcare costs. Moderate and severe forms require medical care. Aciclovir should be prescribed if the diagnosis is made early (3 days) in combination with symptomatic care. Studies of the medical and economic impact of herpetic gingivostomatis should be conducted.

Acyclovir↗

[Reflex sympathetic dystrophy of childhood: one case].

INTRODUCTION: Reflex sympathetic dystrophy (Complex Regional Pain Syndrome type 1) is little known by dermatologists. We report a pediatric case of reflex sympathetic dystrophy with predominant cutaneous involvement. CASE REPORT: A 10 year-old girl presented a warm, painful and relapsing right hand edema for seven months (three outbreaks). The hand was cyanotic, pigmented and painful. Routine blood tests were normal. Radiography and radionuclide bone scan were consistent with stage 1 reflex sympathetic dystrophy. Physiotherapy led to dramatic improvement. DISCUSSION: Reflex sympathetic dystrophy is known since the XVIIIth century. In the last decade, progress in radiology and bone scan have provided elements for understanding the physiopathology of the disease. Microvascular abnormalities under the control of sympathetic nervous system are characteristic of different stages of reflex sympathetic dystrophy. Recently, neurovascular system experiments showed that sympathetic reflex tonus changes may be controlled by the central nervous system. Dermatologic changes of reflex sympathetic dystrophy are well known: edema and erythema in first stage, cyanosis in second stage, sclerosis and atrophia in third stage, but pediatric cases are rarely reported. CONCLUSION: Reflex sympathetic dystrophy is a complex disease, however its physiopathology is now understood. The clinical presentation can be atypical and the dermatologist may be the first to be consulted.

Child↗

[Langerhans-cell histiocytosis and Erdheim-Chester disease: probably not a fortuitous association].

BACKGROUND: Erdheim Chester disease (MEC) is a rare non-Langerhans cell histiocytosis characterized by multi-visceral involvement. We report a case of MEC associated with Langerhans cell histiocytosis (HCL). CASE REPORT: A 46-year-old women presented skin and vulvar localization of HCL associated with typical MEC bone involvement. Despite chemotherapy (vinblastine) and prednisone, the disease progressed to involve the central nervous system, leading to fatal outcome. Post-mortem examination showed HCL in skin, MEC in bones and central nervous system, and intermediate histiocytic proliferation in the encephalon. DISCUSSION: Usually, MEC and HCL are considered as distinct entities. MEC is characterized by a xanthogranulomatous proliferation of CD 68+ foamy histiocytes nested in fibrosis, and HCL by a proliferation of PS 100+ and CD1a+ Langerhans cells. However, our observation, as well as previous reports, suggests that MEC is part of the HCL spectrum.

Bone Diseases↗

[Genital herpes].

Herpes is the first cause of genital ulcers, recurrences are unpredictable and asymptomatic viral excretion is frequent. Herpes simplex virus 2 is responsible for genital infection in 80% of cases, but the incidence of Herpes simplex virus 1 is rising. New diagnostics methods are developing, batcellular viral culture remains gold standard. Oral aciclovir is the standard treatment, and directions for use are strictly codified. In pregnant women a new preventing project is proposed, it does not prevent transmission during asymptomatic viral excretion. In immunocompromise patients Herpes is frequent severe and sometimes aciclovir resistant.

Acyclovir↗

[Herpetic-like worsening of an epidermolysis bullosa simplex during pregnancy].

INTRODUCTION: Episodes of hereditary epidermolysis bullosa simplex are usually provoked by repeated cutaneous traumas or exposure to heat. We report a case of hereditary epidermolysis bullosa simplex worsened during pregnancy. OBSERVATION: A 21 year-old woman suffering from hereditary epidermolysis bullosa simplex presented with unusual symptoms in the form of an extensive vesicular-bullous eruption at two months of her first pregnancy. Standard histological examination revealed an eosinophilic infiltrate in the bullae. The global results of the initial examinations suggested a herpetic-like episode of epidermolysis bullosa as is observed during the Dowling-Meara form of the disease. DISCUSSION: Various physiopathological hypotheses can be advanced to explain the worsening of the eruption during pregnancy: a mechanical origin with scratching of pruritus, enhanced fragility of the inter-keratinocyte bridges secondary to edema provoked by salt-water retention or a loss in antigenic tolerance to muted keratins 5 and 14, as in pemphigoid gestationis. The presence of eosinophils in the dermis and epidermis may also participate directly in the formation of bullae due to the release of cationic proteins.

Adult↗