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Biomedical subjects

F Bonneville

Publications and source records attributed to F Bonneville.

At least 37 records · Page 2Linked to original sources
PubMed2002

[Gadolinium in arteriography and interventional radiology: 39 patients].

OBJECTIVE: To report the experience of using various Gadolinium chelates as contrast media in digital subtraction angiography in patients with relative or absolute contraindications for iodinated contrast agents. MATERIAL: and Methods. Forty-two arteriograms were performed in 39 consecutive patients using Gadolinium chelates (gadoteridol, gadodiamide, and gadopentetate dimeglumine). The vasculature of the brain, of the upper and lower limbs and the renal arteries were examined. Among these 39 patients, 17 were treated by various endovascular procedures. RESULTS: In 40 examinations out of 42, the angiographic result was satisfactory, allowing either a diagnostic evaluation or an endovascular therapeutic procedure. Clinical tolerance was excellent. In one case of renal failure that was reported after angiography, the patient had received both iodine and gadolinum-based contrast agents. CONCLUSION: Gadolinium appears to be an interesting alternative for arteriography in patients with absolute or relative contraindication to iodinated contrast agents, and also seems to demonstrate efficacy during endovascular therapeutic procedures.

Aged↗
PubMed2001

[Increased T1 signal of the residual normal anterior pituitary gland following medical treatment of pituitary prolactinoma].

PURPOSE: To illustrate that residual normal pituitary gland may show hyperintense signal on T1-weighted image after medical treatment of pituitary prolactinoma. MATERIAL: and methods. Three patients treated with bromocriptine for a prolactinoma and showing hyperintense signal of the residual normal pituitary tissue on T1-weighted images were studied. In all patients, measurements of the anterior pituitary gland signal (APGS) and the temporal lobe white matter signal (TLWMS) were obtained by a "region of interest" (ROI) on coronal T1-weighted images. The APGS/TLWMS ratios were calculated and compared to those of a control group of 30 normal subjects. RESULTS: In the three patients, the measurements obtained by ROI confirmed the visual impression of high signal of the residual normal pituitary tissue. Ratios were ranging from 1.15 to 1.21, while they were ranging, in the control group from 0.92 to 1.09. CONCLUSION: In patients with prolactin-secreting adenoma seen after medical treatment, high signal of the residual normal pituitary tissue can be observed, probably due to cellular hyperactivity as it can be noticed during some physiological states. This pattern has to be differentiated from other pituitary abnormalities demonstrating T1 hyperintensity such as hemorrhagic changes of a prolactinoma.

Adult↗
PubMed2000

Dural enhancement in pituitary macroadenomas.

We describe the normal dural enhancement patterns of the sellar region and determine whether the duramater is affected by pituitary macroadenomas. Dural enhancement appeared to be usually abnormal in 20 patients with pituitary macroadenoma compared with 20 control patients, mainly at the planum sphenoidale and carotid sulcus. However dural changes are subtle and their recognition requires knowledge of the normal enhancement patterns. Dural changes, reported in a variety of inflammatory and infectious dural diseases and after surgery, are not specific and may be also seen in pituitary macroadenomas.

Adenoma↗
PubMed2000

[Facial palsy, enhancement of cranial nerves and Lyme disease].

Lyme disease involves multiple organ systems including in 10-15% of cases, the nervous system. Cranial neuropathies are observed in the second stage of the disease. The facial nerve is the most frequently affected nerve (20-30%). Facial nerve enhancement may be associated with cochleovestibular nerve abnormalities and can mimick an intracanalicular pseudomass. We present post-gadolinium enhancement of multiple cranial nerves associated to an intracanicular enhancement illustrated in a patient referred for a facial nerve palsy and presenting a Lyme disease. We discuss the differential diagnosis.

Adult↗
PubMed1999

[Patient information and iodized contrast media].

UNLABELLED: Prior information to patients concerning the risks associated with intravenous injection of contrast media for diagnostic imaging is rarely performed in France. PURPOSE: Evaluate patients' desire for information about risks of intravenous injection of contrast material and its impact on their level of confidence. MATERIAL AND METHODS: Two hundred and twenty seven adult patients, while awaiting a CT scan with injection, read an information form reviewing the risks associated with intravenous injection of contrast material. They filled out an answer sheath concerning their desire to be informed and the impact of that information on their level of confidence. Two levels of risk were evaluated, one where the risk of death was included and one where the risk of death was not included. RESULTS: Eighty six percent of patients wished to be informed about the risks; eleven per cent felt they became more anxious after being informed, irrespective of the mention or not of the risk of death. CONCLUSION: Patients wish to be informed about the risks associated with the intravenous injection of contrast material. This information seems to create only mild anxiety.

Adult↗
PubMed1996

The hereditary pancreatitis gene maps to long arm of chromosome 7.

Hereditary pancreatitis (HP) is an autosomal dominant disorder with incomplete penetrance characterized by recurring episodes of severe abdominal pain often presenting in childhood. Although this disorder has only been recently described, about 100 families have been documented worldwide. The pathophysiology of this disorder is unknown. Here, a large French family of 147 individuals (47 of whom were affected) from a four-generation kindred with HP has been examined and a genome segregation analysis of highly informative microsatellite markers has been performed. Linkage has been found between HP and six chromosome 7q markers. Maximal two point lod scores between HP and D7S 640, D7S 495, D7S 684, D7S 661, D7S 676 and D7S 688 were 4.00 (theta = 0.143), 5.85 (theta = 0.143), 4.91 (theta = 0.156), 8.58 (theta = 0.077), 8.28 (theta = 0.060), 4.40 (theta = 0.169), respectively. Multipoint linkage data combined with recombinant haplotype analysis indicated that the most likely order is: D7S 640-D7S 495-D7S 684-D7S 661-D7S 676-D7S 688, with the HP gene situated in the underlined region. As in all families reported in the literature, the clinical presentation of the disease is identical to the presentation of sporadic cases, one could expect that the knowledge of the HP gene could be a clue to pancreatitis in general. Based on its map position, this is the first step towards the positional cloning of the Hereditary Pancreatitis Gene (HPG).

Chromosome Mapping↗
PubMed1993

[Kidney transplantation and HLA-DR compatibility evaluated by genomic analysis: one center study].

The actual effect of HLA-DR matching in renal transplantation remains controversial. Since DNA analysis has been shown to be more reliable than serological typing, a re-evaluation of the impact of DR-matching on graft prognosis is required. In this study, 224 cadaver kidney transplantations performed in our center were retrospectively matched according to Restriction Fragment Length Polymorphism DR incompatibilities and compared to prospective serological DR-matching. Transplant outcome was evaluated using graft survival, first rejection onset and rejection frequency. In 18.8% individuals, a discrepancy between serology and DNA typing for at least one antigen was noted. Serology particularly failed to type recipients (21.7%) and 43.2% of the total missed antigens were serologically "blank" or unidentified ("X") alleles. A graft survival rate of 100% after one year was observed for transplantations with no DNA DR mismatch (n = 31). Furthermore, there was a definite correlation between DNA matching and (i), the percentage of individuals with one or more than one acute rejection episode (18% and 41.8% at one year for O incompatibility and pooled 1 and 2 incompatibilities respectively, p < 0.05); (ii), the mean of acute rejection per individual (p < 0.001); and (iii), the rejection onset time (p < 0.01). No correlation between serological matching and the acute rejection episodes parameters was noted. Since HLA typing could be performed in less than 2 hrs using new molecular biology techniques, we conclude that prospective DNA typing should improve kidney transplantation outcome in the near future.

Graft Rejection↗
PubMed1991

Molecular cloning and characterization of a complete Chinese hamster provirus related to intracisternal A particle genomes.

We report here the nucleotide sequence of a full-length Chinese hamster genomic proviral element, CHIAP34. CHIAP34 is 6,403 bp long with long terminal repeats of 311 bp at each end. The genetic organization of CHIAP34 was determined by comparison with intracisternal A particle (IAP) genetic elements from the mouse and Syrian hamster. Extensive homology at the nucleotide and deduced amino acid sequence levels was observed between CHIAP34 and the mouse and Syrian hamster IAP elements. CHIAP34 may represent a defective Chinese hamster IAP genetic element. The gag gene consists of 837 codons, of which 558 codons are in a single long open reading frame followed by several frameshifts. The pol gene begins with a -1 frameshift and consists of a long open reading frame of 753 codons followed by a short open reading frame of 103 codons. The putative env region contains multiple termination codons in all reading frames. CHIAP34 is representative of the predominant retroviral elements in the Chinese hamster ovary cell genome present at around 80 copies per haploid genome.

Amino Acid Sequence↗
PubMed1989

Differential expression of MHC class II antigens in myelomonocytic leukemia cell lines.

Major histocompatibility complex (MHC) class II antigens are discordantly expressed on hematopoietic progenitor cells. Their expression is linked to differential responsiveness of the cells to growth factors and inhibitors. We examined the expression of different MHC class II antigens in a panel of human myelomonocytic cell lines representing different stages of differentiation, by cytofluorographic analysis with monoclonal antibody (MoAb) and Northern blot analysis with specific cDNA probes. These analyses revealed discordant expression of different MHC class II antigens both in basal state and after gamma-IFN induction. Thus KG-1 myeloblast cells express all class II antigens (DR greater than DP greater than DQ) constitutively and their expression increased after gamma-IFN treatment. KG-1a, an immature blast variant of KG-1, does not express class II antigens, even after gamma-IFN treatment. THP-1, a monocytic cell line expresses DR but not DP or DQ under basal conditions. DP and DQ are, however, gamma-IFN inducible. The class II negative HL-60 promyelocytic cell line, expresses DR and DP but not DQ after gamma-IFN induction. In all the above cell lines, surface expression of class II antigens correlated with the levels of mRNA expression as determined with specific cDNA probes. In U-937, a monocytic cell line, no surface expression of class II MHC antigens was observed either with or without gamma-IFN, however, specific mRNA message was observed under basal conditions and was further increased with gamma-IFN, indicating a possible defect in assembly or transport of class II antigens. The patterns of class II MHC antigens in these leukemic cell lines may be a useful model to delineate molecular basis of discordant MHC class II expression during myelomonocytic differentiation.

Animals↗
PubMedDate not supplied

[Modification of intestinal colonization and translocation of Campylobacter jejuni by erythromycin and an extract of Lactobacillus acidophilus in axenic mice].

Erythromycin (15 mg) or lyophylized heat-killed Lactobacillus acidophilus (80 mg) were administered per os daily in germ-free mice infected at day O with 10(7)-10(8) Campylobacter jejuni per os. Bacterial colonization of intestine and bacterial translocation of C. jejuni toward mesenteric lymph nodes, blood and liver were then studied for 5 days. The results were compared with those from an infected untreated control group. Compared to the control group, the numbers of free and mucosa-associated bacteria decreased at day 5 in the erythromycin-treated group and the number of mucosa-associated bacteria was reduced from day 1 to day 5 in the Lactobacillus-treated group. Both treatments reduced the frequency of bacterial translocation toward mesenteric lymph nodes from day 1 to day 5. We concluded that both erythromycin and heat-killed L. acidophilus are effective in treating Campylobacter infection in mice, though probably through different mechanisms.

Animals↗
PubMedDate not supplied

Unusual lesions of the cerebellopontine angle: a segmental approach.

Tumors of the cerebellopontine angle (CPA) are frequent; acoustic neuromas and meningiomas represent the great majority of such tumors. However, a large variety of unusual lesions can also be encountered in the CPA. The site of origin is the main factor in making a preoperative diagnosis for an unusual lesion of the CPA. In addition, it is essential to analyze attenuation at computed tomography (CT), signal intensity at magnetic resonance (MR) imaging, enhancement, shape and margins, extent, mass effect, and adjacent bone reaction. CPA masses can primarily arise from the cerebellopontine cistern and other CPA structures (arachnoid cyst, nonacoustic schwannoma, aneurysm, melanoma, miscellaneous meningeal lesions) or from embryologic remnants (epidermoid cyst, dermoid cyst, lipoma). Tumors can also invade the CPA by extension from the petrous bone or skull base (cholesterol granuloma, paraganglioma, chondromatous tumors, chordoma, endolymphatic sac tumor, pituitary adenoma, apex petrositis). Finally, CPA lesions can be secondary to an exophytic brainstem or ventricular tumor (glioma, choroid plexus papilloma, lymphoma, hemangioblastoma, ependymoma, medulloblastoma, dysembryoplastic neuroepithelial tumor). A close association between CT and MR imaging findings is very helpful in establishing the preoperative diagnosis for unusual lesions of the CPA.

Cerebellar Neoplasms↗