Biomedical subjects
F Bolumar Montrull
Publications and source records attributed to F Bolumar Montrull.
[Survival in cancer of the breast in Zaragoza (1960-1990) in relation to age, clinical stage and period of time of the diagnosis].
BACKGROUND: The characteristics of a population based series of 3,066 women diagnosed with breast cancer collected by the Cancer Registry of Zaragoza, Spain from 1960 to 1990 are herein described. Gross short and long term survival, as well as specific survival were estimated according to age at diagnosis, tumor stage and the period in which the patient was diagnosed. METHODS: Every patient was followed up to verification of death or to the latest information available up to January 1, 1991. Diagnosis specified in writing in the clinical history and support by surgical or anatomopathologic reports were required. The data concerning place and site of residence and the vital status of the cases were verified by the municipal and civil registries, death certificates and burial registries. The survival curves were estimated by the Kaplan-Meier method, and short and long term survival, by age and tumor stage at diagnosis and the diagnostic period were also evaluated. RESULTS: Gross survival was estimated as 89.1% in the first year, 50.9% at 5 years, and 34.7%, 28.4% and 20.0% at 10, 15, 20 and 25 years, respectively. Survival at 5 years according to TNM clinical stage classification (UICC-AJC 1978) was 90% for stage I, 69.5% for stage II, 44.6% for stage III and 20.6% for stage IV. The cases diagnosed between 1980 and 1990 presented better survival than those previously diagnosed. The differences were statistically significant in all the cases (p < 0.001, log-rank test). CONCLUSIONS: A slight improvement has been observed in the survival of women diagnosed with breast cancer in Zaragoza, Spain during the study period. Despite of that fact, the survival rates were worse than those observed in other countries with similar socioeconomic development.
[The incidence of human immunodeficiency virus type-1 (HIV-1) infection in parenteral drug users].
BACKGROUND: Cohort studies estimating rates of incidence are scarce despite they are the most appropriate for following the epidemics of HIV-1 and evaluating the effectiveness of preventive interventions. The rate of incidence of infection by HIV-1 in intravenous drug users (IVDU) and the determining factors for such infection are estimated in the present study. METHODS: 3,693 IVDU attended in two centers for information and prevention of AIDS from 1987-1992, were included in the study. Out of 1,868 seronegative subjects, 579 attended a second visit in which a new serologic test was performed against HIV-1. The rates of incidence and 95% confidence intervals were calculated with a Poisson regression model being adjusted in order to control the confounding factors. RESULTS: The estimated global incidence was 11.7/100 people/year (CI 95%: 9.6; 14.46). Those highest rates were observed in IVDU who exchanged syringes (23.5/100 people/year), in those who had more than one sexual partner in the previous month (21.2/100 people/year), in those referring a history of prostitution (22.6/100 people/year), in carriers of hepatitis B antigens (25.6/100 people/year) and in the IVDU younger than 20 years of age (16.5/100 people/year). The variables which independently predicted the rates of incidence were: the exchange of syringes (RR = 6.85; CI 95%: 3.99; 11.75), having more than one different sexual partner in the previous month (RR = 3.51; CI 95%: 1.70; 7.20) and age, with lower risk in those under the age of 20 (RR = 0.49; CI 95%: 0.25; 0.95). CONCLUSIONS: The incidence of infection by type-1 human immunodeficiency virus observed in intravenous drug users is the highest described in Western countries. Preventive measures in general must be intensified particularly in subgroups of intravenous drug users with the greatest risk of seroconversion.
[Knowledge and beliefs in relation to diseases preventable by vaccination and their prevention. Study in the community of Elche (Alicante)].
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[Multiple coding of death causes: analysis of a sample of statistical mortality bulletins].
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[Response level of controls selected from the municipal registry].
The results related to the controls response rate in a case-control study are presented. The study was designed to learn about the relationship between the occupational exposure to toxic products in the parents and the development of acute leukemia in childhood. 128 cases were enrolled in the study and each case was matched by sex and age (less than 15 years) to a control. Controls were selected from the Municipal roll of the same city or town in which the case has been living during the diagnosis. We contacted the control's mother by phone or by personal visit. The response rate was 47.9% and near to a half of non responses was due to errors in the addresses registered in the Municipal roll. The validity of this source of controls in Spain can be questioned in the light of the high percentage of errors. We also discuss the potential selection bias introduced in the study due to the way we selected controls.
[Epidemiological study of measles in Spain from 1949 to 1980, with special reference to Andalusia].
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