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Biomedical subjects

F Boismare

Publications and source records attributed to F Boismare.

126 records · Page 7Linked to original sources
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[Haemodynamic and metabolic effects of exercise test in diabetic patients with arteritis treated or not with nicergoline (author's transl)].

A randomised crossover study in eleven diabetic patients with arteritis compared the effects of nicergoline (2,5 mg i.v.) or placebo on haemodynamic and metabolic parameters after exercise tests. Haemodynamic modifications after effort following placebo administration were typical: raised systolic blood pressure, and increased heart rate and myocardial oxygen requirements (systolic BP x heart rate). Modifications after similar effort following nicergoline involved an increase in systolic B.P. only, heart rate and myocardial oxygen requirements remaining unchanged. Blood lactic acid levels after effort and treatment were significantly higher (p. less than 0.01) than after effort without treatment. Overall metabolic and haemodynamic results demonstrate an increase in effort tolerance in diabetic patients with arteritis after nicergoline, this having been previously observed in healthy subjects.

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[Comparative vasodilator action of 5 vasodilators: dihydroergotoxine, nicergoline, papaverine, naftidrofuryl and buflomedil on the femoral artery of the dog].

1. Papaverine (PAP), Naftidrofuryl (NAF), Buflomedil (BUF), Nicergoline (NIC) and Dihydroergotoxine (DIT) were injected in the dog iliac artery at increasing doses (25, 100, 400, 1600 micrograms . kg-1) successively at 10 minutes intervals and the femoral blood flow was measured with an electromagnetic flowmeter. The same volume of saline was injected in the contralateral iliac artery. Heart rate and radial artery pressure were measured and the femoral resistances computed. Noradrenaline (2 microgram . kg-1) was injected before and after the highest dose of vasodilators. 2. The three muscular vasodilators (PAP, BUF, NAF) had an immediate, powerful, dose-dependent but short lasting effect since only after 1600 microgram . kg-1 of PAP, there was still a significant vasodilator effect after the tenth minute. Little or no effect was observed on systemic blood pressure except for the higher doses of these compounds which produced a slight decrease accompanied by a simultaneous tachycardia. 3. The two ergot derivatives NIC and DHT caused a moderate but much longer acting decrease of femoral resistance although 100 micrograms . kg-1 DHT also caused an increase of the femoral resistance. This biphasic effect has been already described on other experimental models. The higher doses of these compounds decreased systemic blood pressure and produced a slight bradycardia as already reported (Boismare and Lefrancois, 1978; Huchet et al., 1981; Moore et al., 1981). The pressor effect of noradrenaline was reversed by NIC and DHT, confirming their alpha adrenoceptor blocking properties.

Animals↗
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[Hypobaric hypoxia effects on a conditioned avoidance response and on ADP, AMP dopamine and noradrenaline cerebral levels in rats treated or not with naftidrofuryl (author's transl)].

Hypobaric hypoxia (300 mm Hg = 7180 m) was performed during 30 min. for a day during five consecutive days in rats treated or not with naftidrofuryl (15 mg/kg- i.p. daily). A conditioned avoidance response studied on five days shows a reduction of the performances in control rats but not ir treated ones. AMP and ADP cerebral levels were unchanged in the two groups. Hypoxia induced in control rats a reduction of the catecholamine cerebral levels which was not observed in treated rats. In conclusion the protection afforded by naftidrofuryl seems to be due mainly to a reduction of the catecholamine utilization during hypoxia.

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