[Treatment of incapacitating orthostatic hypotension with pindolol in diabetic autonomic neuropathy].
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Diabetic Neuropathies↗
Biomedical subjects
F Boesen
Publications and source records attributed to F Boesen.
The conductance to outflow of CSF in adults with high-pressure hydrocephalus.
The intraventricular pressure was compared with conductance to outflow of CSF (Cout) in 12 patients with high-pressure hydrocephalus of less than 3 months duration. Cout was measured by a lumbo-ventricular or a ventriculo-ventricular perfusion test. In all patients Cout was very low (median 0.016 ml mm Hg-1 minute-1). Thus high-pressure hydrocephalus may be considered to be the consequence of a greatly increased resistance to resorption of CSF. The level of the measured ICP (mean: ICP 23.5 mm Hg) corresponded to the theoretical level calculated from the measured Cout. B-waves were observed during most of the recording periods and episodes of plateau waves were seen in all patients but one. In this particular group of patients, the unsatisfactory results of ventriculo-atrial shunting emphasize the high risks associated conditions leading to high-pressure hydrocephalus.
Adult↗
Treatment of diabetic orthostatic hypotension with pindolol.
The hemodynamic variables, plasma noradrenaline and plasma renin concentrations were studied in a 57-year-old female with insulin-dependent diabetes of long-standing and orthostatic hypotension. For 6 months she had been bedridden because of severe orthostatic symptoms. Reflex responses in the heart rate and blood pressure during the Valsalva manoeuvre as well as beat-to-beat variations in heart rate were absent. Plasma noradrenaline concentrations were subnormal both in the supine and upright positions. After treatment with Pindolol 15 mg/day the patient was able to walk around and lead an almost normal life. The orthostatic symptoms recurred after withdrawal of therapy and disappeared on resumption of therapy. Arterial blood pressure measured intra-arterially decreased less in the up-right position during treatment with pindolol compared to that in the untreated condition. The heart rate did not change during treatment with Pindolol. Our findings suggest that Pindolol may be an important drug in the treatment of diabetic orthostatic hypotension.
Autonomic Nervous System Diseases↗
2 cases of reversible liver lesion induced by valproate.
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Adult↗
Cerebral computed tomography in men with acquired immunodeficiency syndrome.
Cerebral CT scannings were performed in 19 homosexual men with the acquired immunodeficiency syndrome (AIDS). Nearly half of them (9 patients) had cortical atrophy. Three patients with toxoplasmosis had cerebral pathology, in two of them with ring enhancement while the third had an ill-defined nonspecific lesion with slight heterogeneous enhancement without ring formation. Two patients with multifocal leucoencephalopathy and non-Hodgkin's lymphoma, respectively, presented non-enhancing, low attenuating lesions at CT.
Acquired Immunodeficiency Syndrome↗