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Biomedical subjects

F Bistoni

Publications and source records attributed to F Bistoni.

At least 217 records · Page 12Linked to original sources
PubMed1978

The state of antitetanus protection in the commune of Perugia.

A serological survey was carried out on the population in the Perugia district to assess the protection level against tetanus. The antitoxin titre was evaluated by indirect haemagglutination test in 983 sera from healthy subjects of both sexes and all age-groups. Only 285 males and 144 females, 33.47% of the subjects, had been immunized prior to the investigation. The research made it clear that the serological antibody level does not always correspond to the anamnestic data on previous immunization. Therefore, it appears that prophylactic treatment against tetanus should be based on objective data, that is, serum antibody titre, in all subjects at risk. This information, thanks to the indirect haemagglutination test, is not difficult to obtain.

Adult↗
PubMed1978

Haemagglutination antibody titre levels which give certain protection against tetanus toxin.

The lowest haemagglutination titre which gives safe protection against tetanus toxin, in sera of vaccinated subjects of both sexes and of all age groups has been assessed, by comparative haemagglutination and neutralization tests. It was established that sera with 1/32 haemagglutination antibody titre have a toxin neutralizing capability of greater than or equal to 0.1 I.U./ml. Lower haemagglutination titers do not assure protective capacity against tetanus toxin.

Animals↗
PubMed1978

Serum antibody level in rabbits submitted to antitetanus active-passive immunization with heterologous horse serum.

Serum antibody titres have been assessed in rabbits submitted to active and active-passive immunization against tetanus with AlPO4 adsorbed vaccine and horse heterologous immune serum. Heterologous antibodies survive in the blood stream no more than six days. Endogenous antibodies, with the adopted vaccination schedule, emerge fifteen days after the first vaccine inoculation. In rabbits undergoing active-passive immunization, the appearance time of endogenous antibodies is delayed, all the more so as the antiserum injected dose increases. Such data stress the opportunity to give up with the use of heterologous immune sera in tetanus prophylaxis, in association with vaccine as well.

Animals↗
PubMed1977

Enhanced early response to tetanus toxoid, in rabbits.

AIPO4 adsorbed tetanus toxoid injected in rabbits according different vaccination schedules, gives rise to antibody responses with varying lag periods. Shortening the intervals among antigen injections, or increasing the quantity of toxoid per dose, makes it possible to reach protective serum antibody levels in 10 days. That is to say, in a period of time shorter than the mean tetanus incubation in man. Although difficult to transfer to man, the exposed data suggest a possible differentiated antitetanus vaccination in subjects at risk, non protected.

Animals↗
PubMed1977

Anti-Candida albicans precipitating antibodies in the sera of surgery patients.

In healthy subjects and in subjects undergoing surgical intervention for neoplastic and other diseases, the behaviour of precipitating antibodies against soluble Candida albicans natigens was studied. In 13,7% of healthy controls the Ouchterlony test was positive. In subjects suffering from intestinal tract neoplasia, the percentage of positive tests was 26,6% before and 66,6% after the intervention. In other two groups of patients affected by neoplasia, the per cent positive results of the tests after intervention were, respectively, 50% and 63,1%. Among non neoplastic patients undergoing surgical treatment, after intervention 35% too proved positive. The data were confirmed by P.E.T. (partigen elution test): specific anti-Candida IgG, and in some cases IgA, could be demonstrated. The diagnostic value of positive Ouchterlony's test against superficial soluble Candida antigens after surgical intervention has been discussed.

Antigens, Fungal↗
PubMed1976

Anti-candida antibodies in human serum. Detection and definition of Ig classes by a new elution technique.

The Partigen Elution Test (P.E.T.), a partially quantitative method for the determination of Ig classes to which the antibodies against superficial Candida antigens belong, has been assessed. The sensitivity of the test is comparable to that of the Ouchterlony test. The P.E.T. has the advantage of simplicity, great reproducibility and absolute specificity. With P.E.T. the level of single class antibodies can be quantitated on the basis of the diameter of immunoprecipitation ring. It seems possible to establish a correlation between the number of precipitation lines in the Ouchterlony test and the diameter of the precipitation ring in LC-Partigen plates. In addition as association among the width of the ring diameter, the Ig classes implicated and the severity of Candida affection is apparent.

Antibodies, Fungal↗