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Biomedical subjects

F Bistolfi

Publications and source records attributed to F Bistolfi.

At least 19 recordsLinked to original sources
PubMed1990

Hodgkin's disease in adults: association with social factors and age at tonsillectomy. A case-control study.

The relationship between socio-economic characteristics, previous tonsillectomy, family history of cancer and risk of Hodgkin's disease (HD) was investigated in a case-control study. One hundred and sixty patients, aged 15-78, with histologically confirmed HD, and 185 hospital controls were interviewed. A statistically significant decrease in risk of HD was observed among subjects with large sibship size (RR = 0.63, C.I. 0.46-0.86) and among those who underwent tonsillectomy prior to the age of 10 (RR = 0.46, C.I. 0.22-0.94). High educational level was associated with an increased risk of HD (RR = 6.68, C.I. I.94-23.08). Analysis by age-group (15-39 yrs and 40 yrs or more) confirmed the role of high educational level as a risk factor in both young and old subjects, while the protective effect of tonsillectomy at an early age seems to be confined to young subjects. Analysis by histological subtype showed a statistically significant decrease in risk of HD in large sibship size for both nodular sclerosis (NS) and mixed-cell subtypes; the role of education and tonsillectomy was observed only for NS. These data confirm the role of social factors in HD risk and suggest a protective effect of tonsillectomy performed early in life that needs to be confirmed in larger population-based studies.

Adolescent↗
PubMed1990

[Multimodal treatment of locally advanced carcinoma of the breast. Experience at the Galliera di Genova Hospital].

All patients with locally advanced breast cancer receiving definitive irradiation (with or without surgery) at the Radiation Oncology Service, Ospedali Galliera, Genova, Italy, from 1969 through 1986, were retrospectively reviewed. Group A consisted of 187 patients, affected with stage III disease, who received radiation therapy after radical surgery. Irradiation of the chest wall and regional lymph node chains was accomplished with divergent tangential beams of Cobalt: the dose was calculated at the mid-plane of the tangential field separation and was 50Gy (2 Gy/day, 5 fractions/week), followed by additional 10-15 Gy boost to the scar. One hundred and five patients received combined hormonotherapy and/or chemotherapy. After a mean follow-up of 49+ months we observed 21 local recurrences (16 in metastatic patients); 64 patients developed only distant metastases. Actuarial survival at 5 years is 55%. Group B consisted of 36 inoperable patients who received definitive irradiation. Radiation therapy planning was very similar to that in group A, even though after 50 Gy the breast and the tumor area were boosted with restricted fields up to a total dose of 80-90 Gy. Fifteen patients received combined hormonotherapy and/or chemotherapy. At the end of the treatment overall response rate was 89%; actuarial survival at 5 years is 38%. Toxicity was generally mild and no death related to the treatment was observed. Our retrospective analysis confirms the importance of a multimodal approach to locally advanced breast cancer in order to free most patients from disease and to produce excellent local control, even though more randomized studies are necessary to improve the long-term survival of these patients.

Adult↗
PubMed1990

[Physico-technical aspects of total skin irradiation with high-intensity-dose electrons].

The authors have addressed the physical and technical problems involved in the total skin irradiation with a linear accelerator Varian Clinac 2100 C expressly preset for this modality with electrons of 6 MeV nominal energy and dose rate of about 2500 UM/min at the isocenter. The six dual field technique has been implemented and the effect of interposed degrading filters has been evaluated with film dosimetry on an anthropomorphic phantom. It was verified that the total skin electron irradiation expressly offered by the manufacturer as an established treatment option on the Clinac 2100 C with high performance ionizing chambers and high dose rate makes the all procedure safer and simpler.

Electrons↗
PubMed1990

[Radiotherapy with electron beams in Italy].

The use in Italy of high energy electrons in radiotherapy is analyzed following the answers of 29 Centres to a questionnaire. The CISDR (AIFB) dosimetric protocol, some noticeable clinical, technical and dosimetric experiences are underlined. At the moment computerized dosimetry, intraoperative radiotherapy and total skin electron irradiation are the topical subjects in high energy electron radiotherapy.

Electrons↗
PubMed1989

[High-dose gynecologic endocavitary brachytherapy. Technical and dosimetric aspects].

The technical and dosimetric aspects are presented of high-dose intracavitary brachytherapy in gynecology. Fifty-five patients (203 insertions) were examined over two years with a remote loading Selectron HDR 60Co unit installed in a dedicated bunker. The dose to the rectal and bladder markers on AP and LL films was calculated before every irradiation, in order to allow the necessary corrections to be made. Uniform irradiation conditions were obtained at each treatment set-up for both tumoral target and bladder and rectal doses. High-dose intracavitary brachytherapy proved to be a safe, reliable and versatile method from the technical and dosimetric point of view both in the treatment of unoperated gynecological malignancies and in postoperative therapy.

Brachytherapy↗
PubMed1989

[Postoperative radiotherapy in the treatment of soft-tissue sarcomas of the limbs: 63 consecutive cases].

Sixty-three patients with soft tissue sarcomas of the limbs received postoperative radiotherapy during the period from 1969 to 1985. The 5 years actuarial survival rate was 77% in 17 patients who underwent wide surgical operations + RT, 59% in 28 patients with marginal surgical excision + RT, 64% in 18 patients who received salvage RT after several recurrences. Locoregional control was higher in the patients with wide surgical operations + RT, while there were no significant differences in the disease free survival from lung metastasis among the three groups of patients.

Adolescent↗
PubMed1987

[Radiotherapy of cerebral metastases of breast cancer. Clinical experience with 67 patients].

Sixty-seven cases of brain metastases from breast carcinoma treated in the period from January 1969 to June 1986 with radiotherapy (high energies on homogeneous volume, 250-300 kV grid roentgenoherapy) have been evaluated retrospectively. Performance status improvement, evaluated according to Order's stages, with increased quality of life has been obtained in 66% of the patients. Results do not appear to be substantially affected from the different techniques and methods of irradiation. However the importance of implementing and performing the radiotherapy treatment in such a way to keep as high as possible the benefit/risk ratio is stressed, owing to the possibility to observe a few long survival patients after brain metastases occurrence.

Adult↗