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Biomedical subjects

F Bessho

Publications and source records attributed to F Bessho.

At least 73 records · Page 4Linked to original sources
PubMed1990

[Acute nonlymphocytic leukemias with 21 trisomy as a sole anomaly].

Two cases of childhood acute nonlymphocytic leukemia (ANLL) with 21 trisomy as a sole cytogenetic change are reported. The first case was a 4-year-old boy with FAB-M5a. 47, XY, +21 was found in 7 of 12 metaphases at diagnosis and in all 15 metaphases examined at relapse 4 years and 3 months later. The second case was a 14-year-old boy with FAB-M1, all 20 cells examined showed 21 trisomy at diagnosis. His peripheral blood in remission revealed normal male karyotype. Although 21 trisomy is relatively common in ANLL of children, 21 trisomy as a sole anomaly is extremely rare, and to our knowledge, only 2 cases (19 included adult cases) have previously been reported.

Adolescent↗
PubMed1989

Acute non-lymphocytic leukemia is not a major type of childhood leukemia in Japan.

The distribution of acute leukemia according to type was examined in Japanese children by three surveys: (1) a review of bone marrow slides of 81 cases diagnosed as acute myelogenous leukemia between 1964 and 1976; (2) a prospective study of 97 cases observed since 1977, and (3) a study of 8108 cases registered with the Children's Cancer Registry of Japan from 1969 to 1984. The results indicate that the ratio of acute lymphocytic leukemia to non-lymphocytic leukemia in Japan is not different from that in other countries.

Child↗
PubMed1989

Chronic myelomonocytic leukemia with chromosomal changes involving 1p36 and hepatocellular carcinoma in a case of Fanconi's anemia.

A girl with Fanconi's anemia developed chronic myelomonocytic leukemia and hepatocellular carcinoma. At the time that chronic myelomonocytic leukemia was diagnosed, all metaphases of the bone marrow cells revealed a chromosomal translocation involving 1p36. It is suggested that the occurrence of this rare type of leukemia in our patient is related to the chromosomal translocation.

Anemia, Aplastic↗
PubMed1989

[Cytological findings of the cerebrospinal fluid at diagnosis of acute lymphocytic leukemia in children--effect of remission induction chemotherapy].

Cytological examination of the cerebrospinal fluid (CSF) was performed in 88 children with acute lymphocytic leukemia at the time of initial diagnosis (54 cases), during (day 1-15, 17 cases) or after (day 37-58, 17 cases) the remission induction chemotherapy. Leukemic cells were found on cytological examination in 23 cases (42.6%), 5 cases (29.4%) and 2 cases (11.8%), respectively, and the incidence of central nervous system (CNS) leukemia had a tendency to decrease during the induction chemotherapy. The follow-up study of 15 cases of CNS leukemia at diagnosis revealed that the leukemic cells in CSF had decreased within 2 weeks and then disappeared after the induction chemotherapy. These findings indicate the therapeutic effect of induction chemotherapy including prednisolone on subclinical CNS leukemia at diagnosis.

Adolescent↗
PubMed1988

Ultrastructural studies of peripheral blood of neonates with Down's syndrome and transient abnormal myelopoiesis.

Ultrastructural studies were performed on blood samples from five neonates with Down's syndrome and transient abnormal myelopoiesis (TAM). Three methods of fixation were employed to detect diaminobenzidine (DAB) reactivity. The first method used glutaraldehyde solution, while the second and third methods used tannic acid-glutaraldehyde mixtures. Before fixation by the second method, specimens were washed in order to eliminate plasma, and before fixation by the third were diluted to lessen the effects of plasma protein. The latter two methods were more sensitive than the first for detection of DAB reactivity, while the third also resulted in better preservation of morphology than did the second. Even the first method was able to detect DAB reactivity in cells of megakaryocyte-platelet series in appropriate sections. Although the majority of blasts appeared with light microscopy to be undifferentiated, their ultrastructural morphology and ultrastructural cytochemistry were in fact found to be quite heterogeneous, consisting of cells of the megakaryocyte-platelet and granulocytic series, including basophils, and erythroid precursors. This finding supported the view that TAM was the result of unstable hematopoiesis rather than true leukemia.

3,3'-Diaminobenzidine↗
PubMed1988

Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorder in Down's syndrome.

Cytogenetic, immunologic, and electron microscopic studies were performed on the blast cells of 28 pediatric patients with Down's syndrome, 13 with acute leukemia (DS-AL) and 15 with transient myeloproliferative disorders (DS-TMD). Clonal chromosome abnormalities were found in the cells of all patients with DS-AL but not those with DS-TMD. The younger ages and higher hemoglobin concentrations, platelet counts, and WBC counts of DS-TMD patients provided a clinical contrast with the frankly leukemic cases. Myelodysplastic syndrome, characterized by a small percentage of leukemic blast cells, was observed in 11 of the 13 patients with DS-AL compared with none in the DS-TMD group. Electron microscopy disclosed a positive platelet peroxidase reaction in each of the 11 DS-TMD patients and in nine of the 13 DS-AL patients. Immunologic studies revealed antiplatelet-megakaryocyte antigens on the blast cells of the majority of patients in both study groups. Our findings suggest that the blast cells in cases of DS-AL and DS-TMD arise from cells of the megakaryocytic lineage or from a myeloid progenitor with the capacity for megakaryocytic differentiation. The high risk of the development of AL in patients with DS who are less than 3 years old may be related to increased megakaryocyte proliferation in this age group.

Acute Disease↗
PubMed1987

[Clinical evaluation of cisplatin in children with malignant solid tumors. Pediatric Cisplatin Study Group].

A cooperative multicenter clinical study on cisplatin in children with malignant solid tumors was conducted in seventeen institutions. Of 63 children entered into the study, 18 patients were treated with cisplatin alone, 33 with a VCAP regimen (VCR, CPA, ADM and CDDP) and 12 with other combination regimens. The numbers of evaluable patients were 14, 27 and 7, respectively. Response rates for neuroblastoma were 37.5% (3/8) with cisplatin alone and 79.2% (19/24) for the VCAP regimen. Major adverse effects were gastrointestinal symptoms, bone marrow suppression and renal impairment. Hearing difficulty, electrolyte imbalance and transient elevation of transaminase were also observed. However, these adverse effects were within a tolerable range of severity. The results of this study demonstrate that cisplatin is a useful drug in the treatment of neuroblastoma.

Adrenal Gland Neoplasms↗
PubMed1986

Testicular histology and function following long-term chemotherapy of acute leukemia in children and outcome of the patients who received testicular biopsy.

Wedge biopsy of the testis was performed in 46 children who had received long-term chemotherapy for acute lymphoblastic leukemia. Occult testicular infiltration was noted in three children (6.5%). Two of three children with biopsy-proven infiltration died of systemic disease in spite of local irradiation and reinduction chemotherapy. Six of 43 children shown to be negative by testicular biopsy relapsed 11 months to 15 years later, and 3 of 6 patients died of systemic disease, but none of the cases developed testicular disease. Chemotherapy-induced gonadal damage was observed in 30 of 46 children, and tubular damage was occasionally still seen 4 years after cessation of treatment. Although gonadal damage usually depends on the cumulative dosage of cyclophosphamide, intact tubular fertility index was found in several children who had received a greater dose of cyclophosphamide intermittently. Induction and maintenance chemotherapy for acute lymphoblastic leukemia had little influence on hormonal function. Testicular biopsy at the time of cessation of chemotherapy seems to be worthwhile for the subsequent strategy of treatment, and long-term surveillance for gonadal damage of long-term survivors will be required.

Age Factors↗
PubMed1986

Height at diagnosis in acute lymphocytic leukaemia.

The heights of children with acute lymphocytic leukaemia were compared with controls matched for age, sex, and period. In contrast to a previous report the subject patients were not taller than their matched controls.

Body Height↗
PubMed1985

Serum lactate dehydrogenase isoenzyme-1 in children with yolk sac tumor.

Although in recent years the evidence of an increase in serum lactate dehydrogenase isoenzyme-1 (LDH-1) in patients with germ cell tumor (GCT) has attracted attention, there have only been a few reports concerning yolk sac tumor (YST), which is a frequent type of GCT in childhood. Serum LDH isoenzymes were determined in eight children with YST, and an increase in LDH-1 was found in seven of them, excluding one in an early stage. On the basis of the findings of serial serum LDH-1 levels during treatment and of LDH isoenzyme pattern in tumor tissues, it is presumed that the increased serum LDH-1 is derived from tumor tissues. LDH-1 seems to be useful as a tumor marker, not specific for YST but associated with the whole spectrum of GCT, for monitoring of YST.

Child, Preschool↗
PubMed1985

Treatment of children with refractory acute lymphocytic leukemia with vincristine and diltiazem.

Six children with refractory acute lymphocytic leukemia were treated with vincristine combined with diltiazem. In four of five children who took the drug as scheduled, a cytolytic effect was observed. One child showed massive cell destruction which caused hyperuricemic nephropathy. The only adverse effect was atrioventricular block in two children, which was completely reversible. Increased neurotoxicity was not observed in any child.

Benzazepines↗
PubMed1985

[Organ dysfunctions caused by cancer therapy in children].

Some of organ dysfunctions due to cancer therapy in children are common to those of adults, but others are specific for children. Even common toxicities may have aspects peculiar to children. For example, cisplatin nephrotoxicity easily causes hypomagnesemic, hypocalcemic tetany in children which is rare in adults. Occurrence of second primary malignancies is serious late effect of cancer therapy. Concerning this problem two factors are important in children. Firstly, children with heritable embryonal cancers are predisposed to develop additional malignancies related and unrelated to therapy. Secondly, proportion of different parts of body of children is different from one of adults and normal tissues distant from the primary radiation field may receive surprisingly large dose of irradiation. For example, a 8-year-old boy received 6 to 9% of dose of prophylactic skull irradiation for acute lymphocytic leukemia to his thyroid. Younger children who have smaller viscerocranium are expected to have larger dose. Children who received antileukemic therapy for 3 to 7 years showed significant delays of linear growth and bone age.

Antineoplastic Agents↗