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Biomedical subjects

F Bertoni

Publications and source records attributed to F Bertoni.

At least 217 records · Page 12Linked to original sources
PubMed1984

Parosteal osteosarcoma.

Forty-one cases of parosteal osteosarcoma were reviewed clinically, radiologically and pathologically. The fibrous and cartilaginous elements of each tumour were graded from I to IV for malignancy. Primary intramedullary involvement was found in one third of Grade I lesions, two-thirds of Grade II and nearly 90% of Grade III lesions. Thirty-five patients with adequate follow-up were also studied and evaluated as to the adequacy of surgical management in relation to the later development of local recurrence or metastasis or both. No metastases were seen from Grade I tumours despite a number of local recurrences. One third of patients with Grade II and half of those with Grade III tumours developed pulmonary metastases and died, all with involvement of the medullary cavity before distant spread. No patients with adequate surgical management developed local recurrence; in those with inadequate treatment there was an 88% local recurrence rate.

Adolescent↗
PubMed1984

Hypertrophic osteoperiostitis in Crohn's disease.

The authors present a case of hypertrophic osteoperiostitis in a patient suffering from Crohn's disease. A review of the literature reveals 10 cases of Crohn's disease or ulcerative colitis with similar affections of the skeletal system, some of which were asymptomatic. This supports the hypothesis that the immunological phenomena which are common to both these intestinal diseases are also the basis of the skeletal affection.

Adult↗
PubMed1984

Primary central (medullary) fibrosarcoma of bone.

Eighty cases of primary fibrosarcoma of bone from the Rizzoli Institute are reviewed. There was a slight male predominance with a wide patient age distribution. Roentgenologically, low grade fibrosarcomas had generally well-defined margins and a "soap-bubble" appearance. High grade tumors appeared permeative and more aggressive. Histologically, the majority of tumors were high grade (3 and 4). Prognosis correlated well with the grade of the tumor. The 10-year survival rate was 83% for low grade sarcomas and 34% for high grade tumors. Local recurrence was a bad prognostic sign.

Adolescent↗
PubMed1983

Mesenchymal chondrosarcoma of bone and soft tissues.

Mesenchymal chondrosarcoma of bone and soft tissues treated at the Istituto Ortopedico Rizzoli are reviewed. The skeletal locations were prominent in five cases. Only two cases were in the soft tissues. Radiographic picture in the bone shows an aggressive osteolysis, with soft tissues invasion. Histologic picture is the same in bone and soft tissues, and is highly distinctive: islands of well-differentiated chondrosarcoma embedded in undifferentiated mesenchymal cells with high malignancy characteristics. The cases showed a poor prognosis, and no patient survived more than four years.

Adult↗
PubMed1983

Vaginal molds for intracavitary curietherapy: a new method of preparation.

A new method of preparing vaginal molds for afterloading intracavitary brachytherapy is described. Our technique makes it possible to obtain the most accurate individualization of therapy as far as dose distribution is concerned by taking into account the patient's anatomy and target volume.

Brachytherapy↗
PubMed1983

Periosteal chondroma. A review of twenty cases.

We are reporting on the cases of twenty patients with periosteal chondroma to stress the importance of a proper clinical and radiographic diagnosis of this lesion. Awareness of the features of the lesion helps to prevent overtreatment of this benign condition, because the cytological findings may be ominous. Even the radiographic pattern may be suggestive of malignant disease. Periosteal chondromas apparently arise from under the periosteum of the diaphysis or metaphysis in adolescents and young adults. Close cooperation between the surgeon, the radiologist, and the pathologist is necessary to achieve proper diagnosis and treatment. Marginal excision is usually effective treatment.

Adolescent↗
PubMed1983

[Technics for irradiation of the neck in the treatment of lymph node metastases from solid tumors of the head and neck region].

Some common irradiation techniques for nodal metastasis of head and neck solid tumors are described and analyzed, that can be performed by means of a cobalt unit or by high energy electron beams. Limits and indications of each technique are evaluated particularly referring to dose distribution in the target volume and to isoeffect levels (TDF, CRE) that can be expected in normal tissues, at the end of treatment for different regimes.

Cobalt Radioisotopes↗
PubMed1983

[Endoscopy findings in gastroduodenal pathology in a group of welders].

Fourteen welders were examined with the purpose to evaluate the incidence and the type of pathologic changes of the gastrointestinal tract due to the exposure to welding fumes. The medical examination was followed by endoscopic and bioptic study of gastric and duodenal mucosa. The results show the presence of pathologic changes, mainly of flogistic type, in all the microscopic investigations, although the appearance of the mucosa was generally normal. Moreover, the results of this investigation suggest that pathologic changes of gastrointestinal tract could precede those of the respiratory tract.

Adolescent↗
PubMed1983

Giant-cell tumor of bone in skeletally immature patients.

Giant-cell tumor of bone is predominantly an affliction of adults and is rarely found in skeletally immature patients. We are reporting six new cases of histologically confirmed giant-cell tumor of bone in patients with radiographically open epiphyseal plates. These patients account for 1.8 per cent of the 326 giant-cell tumor of bone observed at the Bone Tumor Center of the Istituto Ortopedico Rizzoli in Bologna, Italy.

Adolescent↗
PubMed1982

[The male gonad in an adrenometabolic syndrome. Morpho-functional findings].

The hormonal and morphological features of the hypogonad condition observed in patients with Cushing's disease have been examined. Endocrine functional exploration carried out in 5 male patient showed normal gonadotropin incretion and excretion levels alongside a reduced plasma level of testosterone and an excess of suprarenal androgens, particularly DHA. Cytomorphological observation of the testicle not only confirms the state of gonadic functional quiescence, but makes it possible to exclude the existence of possible intrinsic changes which make gonads unable to respond to tropin stimulus. It is considered that, as is observed in normal humans under corticosteroid load, the excess of glycocorticoids in Cushing's disease depresses testicular endocrine activity, without activating feedback with gonadotrophic hypophysis, since the suprarenal androgens replace testosterone in the counter-regulation mechanism.

17-Hydroxycorticosteroids↗
PubMed1982

Periosteal chondrosarcoma and periosteal osteosarcoma. Two distinct entities.

This review of 27 cases serves to emphasis that periosteal chondrosarcoma and periosteal osteosarcoma are two distinct entities. Clinically, periosteal chondrosarcoma is less painful than periosteal osteosarcoma and runs a slower course. Radiographically, periosteal chondrosarcoma tends to affect the metaphysis and contains granular or "popcorn" opacities; while periosteal osteosarcoma more often affects the mid-diaphysis and shows lytic lesions with some spicules of reactive bone perpendicular to the underlying cortex. Histologically, periosteal chondrosarcoma shows lobular well-differentiated cartilage with Grade I or II (rarely Grade III) malignancy; periosteal osteosarcoma has a chondroid matrix with some osteoid component and Grade II or III malignancy. The prognosis in periosteal chondrosarcoma is good; conservative surgery is usually effective and metastases are very uncommon. In periosteal osteosarcoma the prognosis is less satisfactory but is better than that of other osteosarcomata; wide surgical excision is, however, needed and the incidence of metastases is about 15 per cent.

Adolescent↗
PubMed1982

Primary non-Hodgkin's lymphoma of bone: results in 15 patients treated by radiotherapy combined with systemic chemotherapy.

The authors report on the results obtained in 15 patients with primary non-Hodgkin's lymphoma (NHL) of bone treated by radiotherapy and polychemotherapy; 86% of the patients (13 of 15) were continuously disease-free at a median follow-up of 70 months (42-104). No local recurrence was observed. The necessity of clearly distinguishing primary non-Hodgkin's lymphoma of bone from Ewing's sarcoma is discussed.

Adolescent↗
PubMed1981

The treatment of osteosarcoma of the extremities: twenty year's experience at the Istituto Ortopedico Rizzoli.

Twenty year's (1959-1979) experience in the treatment of osteosarcoma at the Bone Tumor Center of the Istituto Ortopedico Rizzoli is presented. During this period 433 cases were recorded, but only 266 were considered. All the patients underwent surgery but after 1970 whole-lung irradiation (1971), immunotherapy (1971), and chemotherapy (1972 onward) were added as adjuvant therapies on a nonrandomized basis. In the group treated with surgery alone the prognosis was very poor: 10% survived nine years or more after the diagnosis, an average disease-free interval of 7.7 months and an average survival time of 13 months. Monolateral whole-lung irradiation had negative results and was abandoned after six cases. Adjuvant immunotherapy with irradiated autologous tumor cells gave moderately positive results in 16 patients, but only by delaying the appearance of first metastases, therefore increasing the time of survival. Adjuvant chemotherapy was performed with three different protocols: one protocol with ADM only and two protocols using VCR + MTX (at medium dose) + ADM, administered according to two different schedules. Superimposable results were obtained with these three regimens. With equal follow-up, the percentage of continuously disease-free patients treated with adjuvant chemotherapy was significantly higher than that of patients treated with surgery alone (P less than 0.001). The patients in the chemotherapy group who had relapses showed a prolonged time (mean = 12.3 months) to the onset of the first metastasis. Adjuvant chemotherapy caused virtually no morbidity and no deaths. Reference is made to the advantages of a large and homogeneous caseload deriving from a single institution to avoid preselection bias and evaluate the effectiveness of new therapeutic approaches when patient randomization has not been employed.

Adolescent↗