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F Berthezene

Publications and source records attributed to F Berthezene.

80 records · Page 5Linked to original sources
PubMedDate not supplied

[Thyroid hormones and the metabolism of lipoproteins].

Variations, generally not very marked, observed in triglycerides levels during thyroid affections are the result of the action of thyroid hormones on very low density lipoprotein (VLDL) metabolism. Hepatic synthesis of VLDL is increased in hyperparathyroidism due to elevation of circulating fatty acids levels, and in hypothyroidism only in obese patients. Catabolism of VLDL is accelerated in hyperthyroidism and slowed in hypothyroidism. The variations are probably related to changes in activity of lipoprotein lipase and/or hepatic triglyceride lipase, as well as structural modifications in VLDL. Variations in cholesterolemia observed during thyroid affections result mainly from alterations in low density lipoprotein (LDL) metabolism, parallel variations occurring in apoprotein B levels. Thyroid hormones increase cholesterol synthesis, and accelerate LDL catabolism by increasing the number of apoprotein B receptor in peripheral tissues and probably by other mechanisms independent of these receptors. Significant variations in cholesterol levels carried by high density lipoproteins (HDL) are not observed during hypothyroidism, an inconstant reduction being noted in hyperthyroidism. Apoprotein A2 levels are unchanged in thyroid disorders, those of apoproteins A1 being reduced in hyperthyroidism and normal in hypothyroidism, though they diminish transiently during substitutive treatment of the latter condition.

Animals↗
PubMedDate not supplied

[Surgical treatment of Graves' disease (author's transl)].

135 patients with goiter treated for Graves' disease have been followed during 10 years (12) 5 to 1 years (64) 1 to 5 years (59) after surgical treatment. The incidence of hypothyroidism increases with the delay (23 % after 1 year, 32,6 % after 5 years, 37,8 % after 10 years). The incidence of relapses is similar (7,4 % after 1 year, 15,5 % after 5 years, 22,2 % after 10 years). There is no predictive value of clinical and biological data. Only the limits of thyroidectomy and the pathological findings can inform on the post operative evolution : relapses are more frequent after subtotal bilateral thyroidectomy, hypothyroidism is more frequent after one total lobectomy + subtotal lobectomy on the other side and in the case of large lymphocytic infiltration.

Adult↗
PubMedDate not supplied

[Evaluation of the potential cardiotoxicity of propranolol-lithium gluconate association (author's transl)].

The association B blocking agent-lithium salt is used for the therapy of some severe hyperthyroidism with cardiotoxicosis. Separately, both drugs depress intracardiac conduction. However by recording the potentials of the His bundle in anesthetized dogs, a potential cardiotoxicity of this association is unlikely since sinusal automaticity alone is importantly slowed. But, these results need further confirmation in man.

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