[Proceedings: Use of prindolol in acute myocardial infarct with control of hemodynamics].
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Biomedical subjects
Publications and source records attributed to F Bender.
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Determinations of Noradrenaline-concentrations (NA) in the myocardium of the atria and ventricles of rats were performed and the influences of Practolol and Tyramine were controlled. Following Tyramine, NA was decreased significantly in all specimens. After preinjection of Practolol, NA depletion was considerably less in the right and left atria compared to control values. By these results, the clinical observation of a preferential antiarrhythmic action of Practolol on atrial extrasystoles and tachycardias may be supported.
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Dye dilution curves (DDC) from 35 patients with arteriovenous fistulas and from 22 patients with hyperthyreoidism were performed and compared with results in 122 healthy subjects. In most cases Cardiogreen was injected into an antecubital vein during reactive hyperaemia. On the arterial side, dye concentrations were recorded by ear oximetry. The appearance time was shortened in most cases. During dilution time dye curves were interrupted by an early recirculation in hyperthyreoidism, whereas in 29 patients with haemodialysis fistulas this interruption was discrete and detectable only when compared with results after occlusion of the fistulas. Different shapes of dilution curves were observed: 1. in most cases DDC seemed to be normal or near normal, often with an accelerated indicator passage; 2. DDC with an interruption of the dilution limb by an early recirculation; 3. DDD, showing a hump of the dilution limb; 4. asymmetrical DDC or DDC with a flat shoulder of the dilution limb and without a recirculation wave. Patients with hyperthyreoidism and arteriovenous fistulas had no different shapes of dilution curves. The results are discussed with special reference to the DDC in patients with central left-to-right shunts.
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