Bipolar II and unipolar atypical depression.
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Biomedical subjects
Publications and source records attributed to F Benazzi.
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OBJECTIVE: To establish the prevalence of late-life depression in unipolar/bipolar depressed outpatients in private practice, to compare it with depression in younger patients and to compare its early/late-onset subtypes. METHODS: Two hundred and three consecutive unipolar/bipolar depressed outpatients presenting for treatment of depression were interviewed with the Comprehensive Assessment of Symptoms and History structured interview and depression severity was assessed with the Montgomery and Asberg Depression Rating Scale and the Global Assessment of Functioning Scale. RESULTS: Prevalence was 21%. Late-life depression had significantly more unipolar/fewer bipolar patients, higher age at onset, longer duration of illness and lower psychiatric comorbidity than depression in younger patients. Severity, psychosis, chronicity and recurrences were not significantly different. Early-onset late-life depression had significantly lower age at baseline, longer duration of illness and more recurrences than late-life depression. CONCLUSIONS: Findings support suggested age subdivisions of depression and provide a picture of private practice late-life depression.
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OBJECTIVE: To determine the outcome of DSM-III-R schizophreniform disorder with good prognostic features. METHOD: A 6-year follow-up of 20 cases was conducted with structured interviews (comprehensive assessment of symptoms and history) and assessments of functioning scales (global assessment of functioning, Strauss-Carpenter Scale). RESULTS: Thirty-five percent of the cases had major affective disorders, 35% had schizophreniform episodes and major affective disorders, 5% had schizophreniform episodes only, 10% developed schizophrenia, and 15% had no disorders. CONCLUSION: The findings suggest an association between schizophreniform disorder with good prognostic features and affective illness.
OBJECTIVE: To determine the prevalence of chronic depression among outpatients seen for depression. DESIGN: Case series. SETTING: Private practice. PATIENTS: Two hundred and three outpatients with mood disorders, excluding patients with comorbid substance abuse disorders and severe personality disorders. OUTCOME MEASURES: Prevalence rate and patient variables (diagnosis, age at baseline, age at onset, sex, number of previous episodes of depression, atypical features, psychiatric comorbidity, psychosis, duration of illness and baseline severity). RESULTS: The prevalence of chronic depression was 46.7%, which is higher than previously reported. The number of depressive episodes was higher, the presence of psychotic symptoms was more common and the duration of illness was longer in patients with chronic depression than in those with nonchronic depression. CONCLUSIONS: Chronic depression is more severe than nonchronic depression and is a prevalent illness in outpatients with depression seen in private practice.
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