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Biomedical subjects

F Becker

Publications and source records attributed to F Becker.

At least 127 records · Page 7Linked to original sources
PubMed1987

Angiotensin converting enzyme inhibitory activity of SCH 33844 (spirapril) in rats, dogs and monkeys.

SCH 33844 is a new non-sulfhydryl-containing angiotensin converting enzyme (ACE) inhibitor. SCH 33844 diacid inhibited hydrolysis of the synthetic substrate hippuryl-histidyl-leucine by rabbit lung ACE in vitro with an IC50 (concentration inhibiting enzyme by 50%) of 0.81 nM. The ester was 83 times less active. Intravenous administration of SCH 33844 and its diacid inhibited pressor responses to angiotensin I (AI) in anesthetized rats with calculated ID50's of 16 and 8 micrograms/kg, respectively. Oral administration of SCH 33844 (0.03-1 mg/kg) inhibited AI pressor responses in conscious rats with a duration of 24 hr at the highest dose. The diacid was inactive. Intravenous administration of SCH 33844 (100-1000 micrograms/kg) or its diacid (30 micrograms/kg) to anesthetized dogs inhibited AI pressor activity and potentiated the depressor response to bradykinin. SCH 33844 inhibited AI responses in conscious dogs following oral administration of 0.3-3 mg/kg. Oral administration of SCH 33844 (1 mg/kg) to conscious monkeys inhibited AI pressor responses for the 4 hr duration of study. In conclusion, SCH 33844 is a potent, orally effective ACE inhibitor in rats, dogs and monkeys.

Angiotensin I↗
PubMed1986

Insulin autoantibodies in the pre-diabetic period: correlation with islet cell antibodies and development of diabetes.

IgG and IgM class insulin autoantibodies were measured by an enzyme-linked immunosorbent assay in sera from members of the Barts-Windsor-Middlesex prospective family study for Type 1 (insulin-dependent) diabetes. One hundred and twelve individuals from 28 families were selected for study on the basis of a clearly defined islet cell antibody status. IgG insulin autoantibodies were found to be significantly associated with islet cell antibody positive (n = 30) versus islet cell antibody negative (n = 57) first degree family relatives (p = 0.002), with increased significance (p = 0.0003) if complement-fixing (CF)-islet cell antibody individuals (n = 20) only were considered. In addition, a significant association of IgG insulin autoantibodies with subsequent development of diabetes was observed within the CF-islet cell antibody positive group (p less than 0.0003). No such associations were found for IgM insulin autoantibodies, but a higher prevalence of these autoantibodies was observed in islet cell antibody negative first degree relatives (n = 57) compared with a control group of 73 Blood Bank donors (p = 0.00007), and they were significantly associated with siblings (n = 48) rather than parents (n = 39), (p = 0.001). We conclude that the presence of IgG insulin autoantibodies and CF-islet cell antibodies confer more risk for future development of diabetes than the presence of either marker alone.

Autoantibodies↗
PubMed1986

Autoimmune premature ovarian failure with polyendocrinopathy and spontaneous recovery of ovarian follicular activity.

Premature ovarian failure accounts for 10% of cases of secondary amenorrhea, and in most cases its cause remains unknown. One mechanism by which it occurs is autoimmune destruction. A 21-year-old patient is described in whom autoimmune ovarian failure occurred in association with Addison's disease and primary hypothyroidism. Although premature ovarian failure is generally considered irreversible, the patient subsequently resumed spontaneous ovarian follicular activity.

Addison Disease↗
PubMed1985

[Frequency of cervical arteriopathies demonstrated by a routinely conducted Doppler test on a patients consulting for a lower-limb arteriopathy. Results of a prospective study of 676 patients].

Routine cervico-encephalic Doppler examinations were conducted during a prospective study of 676 patients with lower limb arteriopathy. The population treated was defined precisely, mainly with respect to sex, age, recruitment factors, mode of discovery of the arteriopathy, lower limb arteriopathy severity stage as defined by Leriche and Fontaine, site of main lesions, vascular risk factors and the existence or absence of a clinical feature suggestive of an associated cervical arteriopathy. A lesional score was defined in order to evaluate results of Doppler in a simple, intelligible manner. This lesional score was determined as a function of each of the elements (numerically rated) to enable the population to be defined. Results of cervical Doppler were normal or showed only slightly stenotic lesions in 80 to 83% of cases, and a cervical arteriopathy in 13% of patients. Results had no effect on the measures to be taken in 87% of cases. Angiography of the cervical axes was performed in 10% of cases and preventive repair surgery on one or more axes supplying the brain was carried out in 6%. It is concluded that routine Doppler cervical examinations are unnecessary in cases of LLA, since the history and findings on clinical investigations enable selection of patients in whom results of Doppler are probably abnormal. In the absence of clinical signs suggestive of associated cervical arteriopathy, cervical Doppler tests demonstrate major carotid artery lesions in only 1 to 2% of cases, whereas under the critical situations defined this figure varies from 18 to 41%. Clinical examination suggests the probably diagnosis of a cervical arteriopathy associated with LLA, and the cervico-encephalic Doppler test assesses the degree of any stenosis present.

Aged↗
PubMed1985

[Value of the so-called "unravelling" Doppler test at the level of the carotid axes during an examination of a lower-limb arteriopathy].

The use of routine, detailed, complete cervical Doppler examinations in patients with lower limb arteriopathy is criticized, based on results in a prospective study of 676 cases. A more compact, rapidly performed examination known as unravelling Doppler is defined for subclavian and carotid axis arterial investigation. Results are assessed based on a prospective study of 330 patients. A selective practical attitude is proposed by definition of two groups of patients: those with the highest risk of presenting cervical arterial lesions (a routine, complete Doppler test is conducted), and those, the most numerous, for whom the unravelling Doppler enables selection of cases most liable to benefit from a more complete examination of axes supplying the brain.

Aged↗
PubMed1985

[Ultrasonic test of key zones and collateral pathways in cases of arteriopathies of the lower extremities].

Justification is provided for the use of maximal methodology of the Doppler arterial examination of lower limbs by an improved approach to the collateral and distal networks and the detection of possibly dangerous lesions in key zones such as the femoral fork. Details are given of the method used for examination of iliac artery axes, the femoral artery intersection, the deep femoral and popliteal arteries and the popliteal supply network, as well as for rating of the distal tibial circulation.

Arterial Occlusive Diseases↗
PubMed1985

[Monitoring by non-flowmeter vascular function tests following lumbar sympathectomy].

Postoperative follow up examinations were conducted using vascular functional explorations (V.F.E.) including thermometry, Doppler, irrigraphy, digital plethysmography and tread mill. Immediate and long-term effects of lumbar sympathectomy have to be distinguished: the majority of hemodynamic variations noted are not due exclusively to lumbar sympathectomy, except for the iatrogenic development of vasomotor inertia (R.H.T. indifferent or negative) and perhaps values with time of the digital flow curve. Results of V.F.E. after lumbar sympathectomy are discussed in relation to three modalities and taking into account the efficacy and extent of the sympathetic chain resection. The question is raised as to the usefulness of lumbar sympathectomy when the pretreatment V.F.E. findings show hemodynamic elements of the type that would be expected after lumbar sympathectomy.

Arterial Occlusive Diseases↗
PubMed1985

[Systolic pressure index at the ankle, a "beacon" of long-term monitoring of lower-limb arteriopathy].

Data is provided to demonstrate the reliability of measuring the systolic pressure index (SPI) for surveillance of lower limb arteriopathy (mainly during postoperative follow-up), the aim being to establish a simple, rapid and reliable surveillance test of high decisional value. Reproducibility of SPI values was studied in two series of patients (personal and collective) and on variations of SPI before and after reconstructive arterial surgery, as well as in cases of arterial bypass degradation. The following threshold values, beacon of the surveillance, were retained: --variations of 15% in relation to a reference examination: non-significant, --variations of 20 to 30%: probably significant, --variations of more than 30%: significant. A drop of 30% or more of the SPI in relation to a postoperative reference value during surveillance after reconstructive arterial surgery suggests the need for a follow-up angiography to detect possible lesions that could affect bypass permeability, whatever the patient's symptomatology.

Ankle↗
PubMed1985

[Vascular functional exploratory methods enabling the assessment of the evolution of lower-limb arteriopathies in the critical phase. Pulpal pulsed signal, digital pressure, transcutaneous PO2 of the front of the foot. Preliminary notes].

Various situations are defined in which viability of a lower limb is compromised and for which clinical data may be insufficient to assess any very short-term progressive tendency during medical or surgical therapy. Among techniques for exploration of vascular function, parameters of pressure and digital pulsatility and measurement of front of foot transcutaneous PO2 can be considered to be reliable means of determination of the degree of permanent ischemia. Their application to assessment of changes in course during therapy is proposed as a supplement to clinical data.

Arterial Occlusive Diseases↗
PubMed1985

[The amplification factor of the Hillestad reactional hyperemia test as a function of glucose status, clinical status and ankle pressure index].

Principles of the reactive hyperemia test are summarized, the method used defined and the amplification factor f described as the ratio of the post-ischemia amplitude of pulsed plethysmographic signal to its baseline amplitude before arterial occlusion. Values for this factor were determined in patients free from occlusive arterial lesions with or without glucose metabolism disorders, in cases after sympathectomy and in patients with lower limb arterial disease stage I-II and extensive occlusive lesions and in stage III-IV. The factor f is either the reflection of the state of vasodilation or vasoconstriction of the lower limbs studied, or the sign of a diabetic neuroangiopathy. Its study requires comparison of values in both limbs of the same subject.

Arterial Occlusive Diseases↗
PubMed1985

[Clinical results of lumbar sympathectomy as a function of the amplification factor of Hillestad's reactive hyperemia test. Apropos of a series of 72 cases of isolated lumbar sympathectomies].

The efficacy of isolated lumbar sympathectomy was studied in 72 patients (36 with claudication, 36 with permanent ischemia) as a function of results of Hillestad's reactive hyperemia test (R.H.T.). Results were also assessed as a function of glucose tolerance, of the stage in Leriche and Fontaine's classification, of angiographic data, of certain pre-operative vascular function exploratory test parameters: systolic index at the ankle, digital pulsatility, segmental impedance plethysmography (irrigraphy), the tibial artery score and particularly the value for R.H.T. in the lower limb contralateral to the one for which sympathectomy was performed. Good results are very probable when the R.H.T. is positive or indifferent only in the lower limb for which sympathectomy is performed. Results were in fact better as the R.H.T. became more positive. Failure of treatment is very probable when the R.H.T. is indifferent in both lower limbs, particularly when the limb involved has an ankle systolic pressure lower than 0.25, an irrigraphic index lower than 0.10, the digital pulsatility has disappeared and the tibial artery score is 2/6 or less.

Aged↗
PubMed1984

[Correlation between the measurement of PO2 by percutaneous route and the measurement of cutaneous irrigation by thermal clearance in the foot in chronic obliterative arteriopathies of the lower limbs].

Possible influence of skin circulation in percutaneous determination of pedal TcPO2 of patients with lower limbs arteriopathy was investigated. Findings demonstrated close correlation between TcPO2 and the morphology of the pulsatile signal on digital plethysmography in hyperemia, and the degree of lower limbs ischemia, particularly during the stage of permanent ischemia. Histograms of skin irrigation values measured by thermal clearance were similar in normal subjects and patients with lower limbs arteriopathy. Values for skin irrigation measured in this way failed to show linear correlations with TcPO2 values. These findings suggest that TcPO2 values reflect any global tissue ischemia at the measurement site and not cutaneous vascularization alone.

Arterial Occlusive Diseases↗
PubMed1983

[Acute ischemia of the lower limbs. Paraclinical non-invasive examination (arteries, veins, capillaries)].

The author defines the conditions under which vascular function studies may have a place in the presence of acute ischaemia of the lower limbs (essentially due to obstruction of a main artery). Ultrasound methods (Doppler, echography) seem to be the most valuable. Digital plethysmographic pulse and measurement of pO2 are used for the early surveillance of the results of treatment. Function studies should be a useful addition to clinical and angiographic findings within a vascular team, by improving estimation of the perfusion of the distal system taken as a whole.

Acute Disease↗
PubMed1982

Diagnostic and therapeutic aspects of multiple sclerosis in urology: use of urodynamic methods of investigation.

Multiple sclerosis, one of the commonest neurological diseases, is associated in a large number of cases with micturition disorders in both its early stage and its later course. Urological complications play a decisive part in mortality. Urodynamic methods have greatly contributed to the diagnostic spectrum in this disease by permitting to demonstrate and classify neurogenic disorders of bladder function and providing the neurologist with closer information on the sites of the lesion. They are also apt to confirm diagnostic conjectures and may help to adapt the therapeutic measures to the special situation.

Adult↗
PubMed1982

[Critical study and Doppler-arteriographies correlations in a homogeneous series of 115 examinations of the lower limbs (author's transl)].

Correlations between the results of Doppler and arteriographic examinations were studied in a series of 115 angiographies of the limbs, including global findings and 10 specific parameters of importance in vascular surgery. Overall results were strictly comparable in 70 % of cases. Detailed study of 1,150 parameters (10 x 115) revealed only 42 occasions (4 %) when Doppler and angiographic results could not be correlated. The percentage error for Doppler when compared with angiography examinations was of the order of 5 %, except for the tibial arteries when a 20 % error rate was found. Lack of correlation between Doppler and angiography findings could be of value for more precise determination of the tibial network.

Angiography↗