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Biomedical subjects

F Beaufils

Publications and source records attributed to F Beaufils.

At least 91 records · Page 5Linked to original sources
PubMed1984

Hemolytic-uremic syndrome: an analysis of the natural history and prognostic features.

Sixty-seven children with hemolytic-uremic syndrome (HUS) were admitted between 1974 and 1981. Of these, 52 (78%) were aged less than 3 years. All children had acute renal failure and 48 (72%) required peritoneal dialysis. The etiology in twenty cases varied from bacterial and viral infections (7 and 5 cases, respectively) to renal irradiation with chemotherapy (2) and preexisting glomerulopathy (1). 5 (7%) children died during the acute phase of the illness. Long-term follow-up (mean 3 years 3 months) of 56 cases showed that 37 children (60%) had so far experienced no functional sequelae and 8 (13%) only mild sequelae while 3 (5%) were on iterative hemodialysis, 3 had severe chronic renal failure and high blood pressure (HBP) and 5 (8%) had HBP and normal kidney function. While the recovery rate was approximately 60% in all age groups, the mortality rate and serious after-effects were twice as frequent (42%) in children over 3 years of age as in those less than 3. Renal histology (total of 37) showed 12 cases of cortical necrosis, 22 of glomerular thrombotic microangiopathy (TMA) and 3 arterial TMA. Prognosis was poor for all cases of arterial TMA and 58% of those exhibiting cortical necrosis.

Acute Kidney Injury↗
PubMed1984

[Treatment of childhood hemolytic-uremic syndrome with urokinase. Cooperative controlled trial].

The results of a controlled therapeutic trial comparing 2 groups of patients presenting with hemolytic-uremic syndrome (HUS) are reported. Group A (15 children) was given urokinase (UK) and heparin; group B (18 children) received no treatment. Ages of patients, the delay before admission, the severity of anemia, thrombocytopenia and initial renal failure were similar in both groups. UK was responsible for bleedings in 12 children, minimal in 8, severe in 4. No child died in group A, 3 children died in group B (n.s.). Durations of hemolysis, thrombocytopenia and anuria were similar in both groups. Long-term evolutions of renal function and arterial pressure were comparable in both groups. Needle kidney biopsy (26 cases) showed cortical necrosis in 3 children of group A and in 2 of group B, and glomerular thrombotic microangiopathy in 10 children of group A and in 11 of group B. The average ratio of injured glomeruli was 40 (19 to 80) in group A, and 38 (21 to 75) in group B. Two children in group A and 3 children in group B presented with 50 to 80% of glomerular lesions. This trial suggests that UK is of no significant value in the treatment of HUS.

Adolescent↗
PubMed1984

Lung functional follow-up in children after severe viral infection.

Pulmonary function tests (PFT) were performed in 12 children after viral infection (VI) due to an adenovirus in 9 cases and occurring before the age of 4 in 10. Functional residual capacity (FRC), thoracic gas volume (TGV), total lung resistance (R1), dynamic lung compliance (C1dyn), expiratory flows and blood gases were measured during three periods after VI: from 3 to 12 months (n = 10), from 1 yr 6 months to 3 yr 8 months (n = 8), and from 4 yr 7 months to 8 yr (n = 6). In the short term period one child had normal PFT, while in the remaining cases there was increased R1, decreased C1dyn and hypoxemia. R1, C1dyn and blood gases did not significantly change between short and mid term periods. In the long term period the children had overinflation with trapped gases, airways obstruction and hypoxemia. These functional sequelae may be related to structural lesions due to VI and abnormal postnatal lung growth.

Adolescent↗
PubMed1983

[Rhabdomyolysis and acute encephalitis in coxsackievirus infection].

We report the case of a 6 year-old boy with rhabdomyolysis involving only the inferior limbs. It was complicated by renal failure with anuria and intravenous coagulopathy and associated with encephalitis. Virologic investigations showed a recent infection due to Coxsackie B5 virus. Full recovery was observed after symptomatic treatment with peritoneal dialysis, exchange transfusion and heparin therapy.

Acute Disease↗
PubMed1981

[Cefotaxime and Gram-negative infections in children. Effectiveness and tolerance (author's transl)].

Twenty-six children, aged from 15 days to 14 years, were treated with cefotaxime. 5 were suffering from septicaemia, 14 from respiratory tract infection and were ventilated (intensive care unit), 4 from urinary tract infection and 3 from otitis media complicated with renal failure (nephrology unit). The choice of cefotaxime treatment was based upon the bacterial activity. The daily dose was 50 to 100 mg/kg by the i.m. route, or by slow intravenous injection every 8 hours. In 17 patients, cefotaxime was combined with an aminoglycoside (gentamicin or amikacin). The results were evaluated on the basis of clinical, radiological and bacteriological criteria and, whenever possible, were correlated to the serum levels of antibiotic. The antibiotic was clinically effective in 25 out of 26 patients. The three deaths that occurred, were due to the nature of the initial disease. Tolerance was good in all the patients studied. The efficacy of cefotaxime correlated well with the favorable in vitro bacteriological results and with serum concentrations. Cefotaxime is well tolerated as shown in newborn babies. Cefotaxime is markedly different from previous cephalosporins, because of its high antibacterial activity on most Gram-negative bacilli.

Adolescent↗
PubMed1981

[The child's intestinal ecosystem: effect of colistin (author's transl)].

A differential quantitative study of the fecal flora was used to appreciated the intestinal bacterial flora of 41 hospitalized children, with no infection and receiving no antibiotic treatment. Thus, it was possible to establish the bacterial normal profile of intestinal of hospitalized child. Because of the stability of the fecal flora in those controls, it was possible to study the effect of colistin on the intestinal ecosystem, in 21 children. Colistin per os, with intestinal nutrition and colistin IM in combination with gentamicin IM did not have any quantitative or qualitative effect on fecal flora. Colistin per os, with exclusive parenteral nutrition caused by disappearance of sensitive strains and their replacement by resistant organisms; this was followed by secondary septicaemia. This fact being a very high infectious risk, it leads us to abstain from administering colistin per os, when the intestine does not receive any food.

Administration, Oral↗
PubMed1980

[Hemodynamic and echocardiographic investigations in children with severe meningococcosis (author's transl)].

In eight children presenting with severe meningococcosis, hemodynamic investigations were performed at various stages of the disease (thermodilution technique and echocardiography). Surveillance of hypovolemia and myocardial incompetence associated with sceptic shock allows a better adaptation of symptomatic treatment and a better prognosis in these severe cases. It seems that invasive hemodynamic methods (thermodilution) cannot be replaced presently by echocardiography alone.

Child↗