[D-thyroxine in the treatment of hypercholesterolemia and arteriosclerosis].
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Adult↗
Biomedical subjects
F Bayard
Publications and source records attributed to F Bayard.
[Physiological and pharmacological regulation of sex steroid receptors in the endometrium (author's transl)].
Oestradiol and progesterone receptors concentration in endometrium is regulated by oestradiol and progesterone themselves. Oestradiol induces the two types of receptors, mainly the progesterone receptor. Progesterone decreases the production of the two types of receptors and probably increases the turnover of its own receptor. Pharmacological agents, synthetic oestrogen and progestins, behave similarly. The antioestrogen tamoxifen has a partial agonistic action of the oestrogen type on progesterone receptor induction. These observations, however, concern the whole tissue. At the cellular level, the regulation of the production of the two receptor types may indeed be different from what is observed in the entire tissue. Finally recent data on the presence of specific binding sites for antioestrogens and on receptor heterogeneity justify new studies of these regulating factors.
Endometrium↗
Choriocarcinoma and endocrine paraneoplastic syndromes.
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Adult↗
Quantitation of RT-PCR products of bFGF-mRNA by capillary electrophoresis and laser-induced fluorescence.
The numerous challenges of modern biology and medical science require the development of analytical methodologies of extreme sensitivity and resolving power. Because it deals with the extraordinary complexity of biological mixtures and minute samples, capillary electrophoresis combined with laser-induced fluorescence (LIF) is now one of the most popular analytical biotechniques. Using polymer matrices and very high voltages, it allows the separation of very low quantities of microsamples and the selective detection of fluorescent species at a level of a few thousand molecules. This method of analysis has been used to quantitate reverse transcription-polymerase chain reaction (RT-PCR) products. In the authors' laboratory, they were looking for a means of analyzing mRNAs of cytokines. In the first attempt, they chose to quantitate RT-PCR products of basic fibroblast growth factor (bFGF)-mRNA, which could be involved in atherosclerosis. The results on two patients confirm the lower quantity of bFGF expressed in internal mammary athery (IMA) biopsies compared to human aortic cells. This study shows the usefulness of CE-LIF to identify and quantitate RT-PCR products and its ability to be used in clinical studies, to find very low levels of bFGF expression in atheroma biopsies.
Arteries↗