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Biomedical subjects

F Bay

Publications and source records attributed to F Bay.

8 recordsLinked to original sources
PubMed2000

Effect of pressure and gas type on intraabdominal, subcutaneous, and blood pH in laparoscopy.

BACKGROUND: According to the literature, the number of port-site metastases in laparoscopic surgery varies considerably depending on the type of gas used for the pneumoperitoneum. In order to investigate this observation we studied the changes in blood, subcutaneous, and intra-abdominal pH during laparoscopy with helium, CO(2) and room air in a rat model. In addition, we looked at the influence of intra-abdominal pressure and duration of pneumoperitoneum on the pH during the laparoscopy. METHODS: pH was measured by tonometry, intra-abdominally and subcutaneously. A pH electrode was additionally placed into the subcutaneous tissue and the results compared to those measured by tonometry. Blood samples were taken from a catheter in the carotid artery. The intra-abdominal pressure was 0, 3, 6, 9 mm Hg for 30 min in each case. We investigated the effect of pneumoperitoneum with CO(2), helium and air in randomized groups of 5 rats. In an additional series the pressure was held constant at 3 mm Hg and the pH was measured every 30 min. RESULTS: Due to the different absorption capacity of the peritoneum, laparoscopy with CO(2) decreases the subcutaneous pH from 7.35 to 6.81. Blood pH is reduced from 7.37 to 7.17 and the intra-abdominal pH from 7.35 to 6.24. Other, less absorbable gases induce smaller changes of blood and subcutaneous pH (only 10% of CO(2)). In a variance analysis the p value is less than 0.001. The influence of duration of laparoscopy (30 min vs. 90 min) on the subcutaneous pH is less compared to the influence of intra-abdominal pressure (0, 3, 6, 9 mm Hg). CONCLUSIONS: Depending on the type of gas (CO(2), air, helium) used for laparoscopy blood, subcutaneous and intra-abdominal pH are influenced differently. Because lower pH is known to impair local defense mechanisms, these results may be one explanation for the higher incidence of port-site metastasis in laparoscopy with CO(2) than with other gases, as reported in the literature.

Abdomen↗
PubMed2000

Laparoscopic liver surgery in the rat: description of a new technique.

BACKGROUND: We devised a safe and simple method of liver resection with a wire loop in a small animal model. Herein the method is evaluated and combined with a tumor model for further immunological, oncological, and laparoscopic research. METHODS: With the aid of a wire loop and an adapted electric generator, a liver lobe resection can be performed through three trocars (first trocar: camera; second and third trocars: instruments). This operative procedure was evaluated in 10 rats (group 1). In a second group of ACI rats, a Morris hepatoma (1 mm(3)) was induced. After 11 days, a liver lobe resection was performed. One week after the resection an autopsy and a histological examination were performed in all animals. RESULTS: Ten ACI rats underwent laparoscopic liver resection to evaluate the operative technique with the wire loop (group 1). All rats returned to normal feeding and activity on the 1st postoperative day. There were no deaths. At autopsy, the resection area was inconspicuous, without any sign of hematoma or bilioma. In the second group, 10 days after tumor induction, the induced hepatoma was increased (1 cm(3)) and localized in the left liver lobe. In all rats, the liver lobe was resected without touching or laceration of the tumor. At autopsy, the resection area was inconspicuous. No tumors were found in the histological workup of liver and lungs. CONCLUSION: This model of laparoscopic liver resection in the rat allows a safe and simple liver lobectomy, including a total tumor resection. It should also facilitate basic oncological, immunological, and laparoscopic research.

Anesthesia↗
PubMed1998

Prospective randomized study of stress and immune response after laparoscopic vs conventional colonic resection.

METHODS: In order to evaluate the stress and immunological response to laparoscopic and conventional colon resection we operated on male Wistar rats (350-380 g), performing either laparoscopic (n = 15) or open colon resection (n = 15). A third group (n = 10) underwent anesthesia only. Immediately before and after surgery as well as 1 and 7 days postoperatively a 1 ml sample of blood was taken from the retrobulbar veinous plexus. Stress (corticosterone) and immune parameters (neopterin and interleukin [IL] 1-beta) were measured. Furthermore, the body weight as a parameter of postoperative recovery was monitored. RESULTS: The analysis of variance showed significant differences between the three groups over a period of 1 week (p < 0.0001 for corticosterone, p = 0.0854 for IL 1-beta, p = 0. 0045 for neopterin). Additionally in a t-test significant differences were found between the laparoscopic and conventional group with regard to corticosterone (p = 0.08), to neopterin (p = 0. 045), and to IL 1-beta (p = 0.0043) at the end of the operation. One week after the operation the stress and immune parameters were back to normal levels in each group except IL 1-beta, but the recovery indicated by body weight was different according to the kind of the applied operative procedure: 7 days postoperatively the rats lost 5. 99% of their body weight after open surgery and only 2.4% after laparoscopic surgery. After anesthesia only the body weight increased by about 4.8%. CONCLUSION: Laparoscopic colon resection alters the stress and immune system of healthy rats less than open colon resection. This observation is confirmed by the quicker recovery in laparoscopically operated rats.

Animals↗
PubMed1997

Anthroposophical medicine: a nursing perspective. Interview by Joanna Trevelyan.

Despite its popularity on mainland Europe, particularly in Germany and Switzerland, anthroposophical medicine remains relatively unknown in the UK. Joanna Trevelyan takes a closer look at this truly holistic form of medicine, and asks Frances Bay, one of the founders of the Anthroposophical Nurses Association in Great Britain, what it can offer nurses.

Anthroposophy↗
PubMed1995

Complementary therapies--just another task?

In this article, the author explores some of the issues involved if nurses wish to incorporate complementary therapies into their role. Amongst others, questions are raised concerning the compatibility of complementary therapies with current health care provision in hospital and community. Aspects of accountability, education and research are touched upon. No answers are offered, leaving readers to draw their own conclusions how best to overcome some of the obstacles mentioned.

Complementary Therapies↗
PubMedDate not supplied

[Coxiella burnetii infections and infections with bacteria of the genus Chlamydia in dairy cattle].

Comparative studies on the prevalence of infections caused by Coxiella burnetii (C. burnetii) and Chlamydia were carried out with 592 cattle older than 2 years and 234 cattle younger than 2 years. Of these 477 originated from 24 dairy herds with considerable fertility problems (positive herds) and 349 from 14 dairy herds without major fertility problems (control herds). For the direct detection of these pathogens in the genitals capture ELISAs were employed, for the demonstration of antibodies the complement fixation test (CFT). Direct detection of C. burnetii and Chlamydia single as well as mixed infection revealed significant higher values for cattle from positive herds compared with those from the control herds. Animals revealing insemination ratios of > or = 2 showed significantly more frequent excretion of Chlamydia via the genitals and antibodies against C. burnetii than cattle with an insemination ratio of < 2. Investigations of cows which had had an abortion showed no indications of significantly more frequent C. burnetii or chlamydial infections. Inseminated but non-pregnant cows excreted significantly more C. burnetii and Chlamydia than pregnant cows. Clinical signs of endometritis were associated with an enhanced excretion of Chlamydia. Animals younger than 2 years excreted significantly more frequently C. burnetii but not Chlamydia via the genitals than animals older than 2 years. Indirect test showed results vice versa.

Abortion, Veterinary↗