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Biomedical subjects

F Bauer

Publications and source records attributed to F Bauer.

At least 55 records · Page 3Linked to original sources
PubMed1990

[Diagnostic value of the early auditory evoked potentials in acute cranio-cerebral trauma in children].

The brainstem auditory evoked potentials were recorded in 54 children within the first 48 hours after a head trauma of different degree. In comparison with an age--appropriate standard group there are changed BAEP in 51% of the examined children after head trauma. The abnormalities mainly consist in changes of the wave--morphology, the latencies of the waves 1, 3 and 5 were significantly prolonged. The interpeak--intervals only unessentially differ from the standard group. The detected BAEP--changes are of different kind and incidence. A typical change of the potential for the infantile head trauma cannot be found. The regression of the traumatically conditioned BAEP--changes begins during the first days after trauma and it is finished within 6 months in half of the children. In the particular case changes can be detected after two years yet.

Adolescent↗
PubMed1989

[Modification of blood coagulation by the anti-arrhythmia drug prajmalium bitartrate in vivo].

We studied the effects of prajmaliumbitartrate (PBT, Neo-Gilurytmal, Giulini Pharma, Hannover, FRG), an antiarrhythmic drug on some parameters of blood coagulation in patients. PBT, 20 mg given three times a day, significantly prolonged template bleeding time and ex vivo thrombus formation time in a modified Chandler's loop. Ex vivo platelet aggregation using different agonists and tests of the plasmatic coagulation system remained unchanged.

Ajmaline↗
PubMed1989

[The effect of the antiarrhythmic, prajmalium bitartrate, on human thrombocyte function].

Studies of the in vitro effects of the antiarrhythmic drug prajmalium bitartrate (PBT, Neo-Gilurytmal) showed inhibitory effects on platelet aggregation and thromboxane production. PBT inhibited the primary and secondary phases of aggregation induced by adrenaline (epinephrine) or adenosine diphosphate (ADP). Platelet aggregation stimulated with collagen, platelet activating factor (PAF), and the thromboxane mimetic 9,11-azo-prostaglandin H2 (U 44064) was inhibited. The secondary phase of aggregation induced by ristocetin and aggregation caused by arachidonic acid (AA) were inhibited in samples from some donors (responders) but not in others (nonresponders). Platelet aggregation by the ionophore calcimycine (A 23187) was not inhibited, but small doses of calcimycine abolished the PBT-induced inhibition of aggregation caused by ADP. Thromboxane production of platelets with collagen of ADP was inhibited by higher concentrations of PBT, whereas AA-induced thromboxane synthesis remained unchanged. The observed antiplatelet activities of PBT are thought to result from calcium and sodium channel blocking properties of the drug.

Ajmaline↗
PubMed1988

[Effect of o-phosphate on the myoglobin spectrum].

o-Phosphate causes myoglobin solutions to change colour from brown to reddish-brown. The spectrum of myoglobin in the presence of o-phosphate is characterized by two peaks, one at 540 nm and the other at 575 nm and also by a shift in the Soret band at 409 nm to 420 nm.

Hemeproteins↗
PubMed1986

Localized thyroid plasmacytoma.

Two cases of localized thyroid plasmacytoma are described and the literature is reviewed. In most cases the tumors arise in thyroid glands with lymphocytic thyroiditis. Thyroidectomy with regional lymph node biopsy seems to be the initial treatment of choice. Postoperative irradiation appears to be indicated in cases with residual thyroid tissue remaining and in those with documented regional nodal involvement.

Aged↗
PubMed1984

[Detection of blood plasma in heat-treated meat products by ultrathin-layer isoelectric focusing].

The detection of blood plasma in heat-treated meat products was performed by means of ultrathin-layer isoelectric focusing. Because of the poor solubility of denatured blood plasma in water or diluted salt solutions the extracts were concentrated by adsorption of the protein on hydroxyl apatite and subsequent elution. Desalting of the samples was done by gel chromatography. Gels with a thickness of 150 micron were used for isoelectric focusing because of their excellent resolution as well as low expenditure of time and cost. 0.2% of dry blood plasma in sausages were still detectable by the method described.

Animals↗
PubMed1983

Anticoagulant properties of three mucopolysaccharides used in rheumatology.

Three mucopolysaccharides (MPS) used in the treatment of degenerative joint disease were compared to heparin to establish their relative potencies on 3 coagulation tests, the aPTT, the antifactor Xa activity and the dilute thrombin time. One of the compounds, Arteparon, was one fourth as potent as heparin on the aPTT, but had little or no influence on the 2 other tests. Further in vitro studies suggested that Arteparon acted at a higher level than factor Xa generation in the intrinsic amplification system and that its effect was independent of antithrombin III. In vivo administration of Arteparon confirmed its anticoagulant properties, which raises the question of the clinical use of this MPS.

Anti-Inflammatory Agents↗
PubMed1983

Salivary electrolytes and digitalis.

The hypothesis that an increase in salivary concentration of certain electrolytes (Ca X K) is a sign of digitalis intoxication was tested in 16 untreated health volunteers, 29 digitalized heart failure patients and four further healthy volunteers given digoxin. Salivary electrolyte levels were raised in only about half the digitalized patients and blood levels of digoxin were not always higher in these patients than in those with normal electrolyte concentrations. The salivary electrolyte levels of the healthy volunteers given digoxin remained normal. These findings would seem to rule out the possibility that digitalis is responsible for the changes in salivary electrolytes observed in certain cases of heart failure. A very marked correlation (P less than 0.00002 by Fisher's exact probability test) was found, however, between an increase in the product of salivary calcium and potassium (Casal X Ksal) and the presence of clinical signs of poorly compensated heart failure. It is suggested that this might be a result of adrenergic stimulation, which is known to occur in heart failure, affecting the salivary glands.

Adult↗
PubMed1982

[Refractory reversible anemia in a case of thyrotoxicosis].

The case is reported of a patient with "refractory" type anemia and acute thyrotoxicosis. There was no evidence of iron or vitamin deficiency, a fact which suggested that the anemia was probably secondary to the acute thyrotoxicosis since correction of the anemia occurred following successful antithyroid therapy with Lugol's solution (aqueous iodine solution) and propylthiouracil without specific hematological treatment. This unusual association of "refractory" type anemia and acute thyrotoxicosis is discussed in the light of data from experimental animal models and the very small number of other cases reported in the literature.

Aged↗
PubMed1981

Quinacrine hydrochloride drug eruption (tropical lichenoid dermatitis). Its early and late sequelae and its malignant potential: a review.

The totality of effects of a particular drug on patients cannot be truly assessed until many patients have taken it. In order to assess the side effects of any drug, many thousands of patients may have to be observed, and the observation may have to extend over decades. Quinacrine hydrochloride (quinacrine) was used as a malarial-suppressive drug by allied soldiers during World War II. The most commonly occurring side effect was a drug eruption. This at times led to permanent sequelae at an early stage. Further observation revealed late sequelae occurring 7 to 17 years after the war. Two of these late sequelae were observed to become malignant, and in most cases the palmar aspect was involved. This is an area which rarely shows malignant change. It has been observed that quinacrine can be instrumental in inducing skin cancers as late as 34 years after its ingestion.

Atrophy↗
PubMed1979

Anatomo-radiological study of a case of post-radiotherapeutic osteolysis of the hip.

Anatomo-radiological study of a case of osteolysis of the femoral head and neck in a 56-year old male who had recieved, 22 years earlier, an intense radiotherapeutic treatment for a soft tissue tumour of the corresponding hip region. The treatment is considered as being the main etiological factor responsible for the bone lesions. The latter seems to have been favored by an indolent joint due to a thoracic cordotomy for post-irradiation pains; it may have been prepared by a secondary osteodystrophy which preceded the radiotherapy and seems due to two previous surgical excisions.

Bone Resorption↗
PubMed1978

[Salivary electrolytes, digitalis glycosides and cardiac insufficiency].

In a group of 29 patients treated with digoxin for cardiac failure, only 16 showed increased calcium and potassium concentrations in saliva. There was no correlation in the 29 patients between serum digoxin levels and concentrations of salivary electrolytes. On the other hand, in 4 normal subjects treated with digoxin no change in salivary electrolytes was noted. It is concluded that modifications in salivary electrolytes seen in patients with cardiac failure treated with digitalis are not due to this drug. However, a retrospective clinical study showed a good correlation between clinical signs of cardiac failure and increased levels of salivary calcium, potassium and CaX Kproduct. It is suggested that this phenomenon is due to the well-known adrenergic stimulation in patients with cardiac failure.

Adult↗