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F Bauduer

Publications and source records attributed to F Bauduer.

59 records · Page 4Linked to original sources
PubMed1992

[Multiple myeloma: current therapeutic approaches].

The therapeutic strategy in multiple myeloma depends on age and tumor mass. Stage I must not be treated. The Melphalan Prednisone regimen is the reference for induction therapy because polychemotherapies are generally not superior. At this phase, the addition of Interferon alpha seems to be interesting. This drug has an important role during the steady-state phase. VAD represents the most efficient chemotherapy. Body hemi-irradiation is also useful. The analgesic effect and the decrease in the tumoral mass are the striking effects of this treatment. In young patients, high dose chemotherapy with bone marrow transplantation is proposed. Verapamil and anti-IL6 antibodies are currently being evaluated. Symptomatic treatment is essential in this non curable disease.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1992

[Plasmocytoma with asynchronous metastasis. Immunohistological and ultrastructural contribution].

The case of a 37-year-old male who developed multiple asynchronous extramedullary plasmocytoma localizations is reported. The first site involved was the cecum. Other tumors successively arose in the chest wall, testis, buttock, nasal cavity, skin, and mediastinum. The patient died 59 months after initial diagnosis. Light microscopy and ultrastructural studies disclosed a substantial proportion of immature plasmocytes in the different tumors, explaining in part the poor activity of radiotherapy and chemotherapy. Although in many cases this clinical pattern indicates multiple myeloma, investigations failed to detect this condition in the patient reported here. Shortly before the fatal outcome, a peak of IgA kappa globulin was detected in the serum. This immunoglobulin was also identified on tumor cells using immunoperoxidase labeling.

Adult↗
PubMed1991

[Prothrombin time, activated partial thromboplastin time, plasma fibrinogen determination. Comparison of two automated coagulation systems: Koagulab 40-A and ACL-100].

In this study the authors compare two automated coagulation instruments: the koagulab-40A (Orthodiagnostics Systems) and l'ACL-100 (Instrumentation Laboratory) using two different methods of detection, photo-optical and nephelemetric respectively. The three parameters studied are: prothrombin time (PT) (82 samples), activated partial thromboplastin time (APTT) (86 samples) and fibrinogenemia (FIB) (109 samples). For each test, they use two reagents of different origins. Samples come from people without any haemostatic disorder and from patients showing abnormal levels of these parameters (heparins or antivitamins K treatments, hypo or hyperfibrinogenemias). For the tree parameters examined, they obtain coefficients of correlation: 0.94 to 0.99 between the two instruments. These values are not noticeably modified by reagent substitution. For fibrinogenemia, the coefficient of variation (CV) is about 4%. Finally, in comparison with the photooptical classical method, the ACL-100 is more rapid, more economical (reduced volumes of reagents) and more feasible (dilutions of plasmas and tubulure changing are not necessary for fibrinogen).

Autoanalysis↗
PubMedDate not supplied

[Medicine in ancient Egypt, a fascinating level of modernity].

Our knowledge about ancient Egyptian medicine (throughout more than three millennia) comes from some papyri, as those of Ebers and Smith, thousands of mummies or skeletons and multiple temples and tumbs decorations. Doctors were initially priests and embalmers which explain their good level in anatomy. The most famous of all, imhotep, who was also architect and minister, became a god of medicine. First hospitals developed from temples. Modern investigation tools are useful for studying on human remains the most prevalent diseases at these times which are comparable with our current medical problems. An increasing number of scientific data, which some examples are reported herein, argue in favor of a fascinating level of advancement of ancient Egyptian medicine in the field of diagnosis and therapy.

Anatomy↗