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Biomedical subjects

F Basset

Publications and source records attributed to F Basset.

133 records · Page 8Linked to original sources
PubMedDate not supplied

[Ultrastructural diagnostic problems of pleural tumors. A study of 125 cases (author's transl)].

Ultrastructural studies may improve the diagnosis of pleural tumors. A comparative study of 125 primary and secondary pleural cancers provided the major structural features needed for differential diagnosis. Two cell types were always present in malignant mesothelioma: differentiated mesothelial, and fibroblastoid cells. The former had some features of metastatic epitheliomas (microvilli, microfilaments, junctional complexes, basement membranes). The later were specific. They were sometimes isolated, had the general aspect of fibroblasts but possessed typical microvilli. It was difficult to assess the diagnosis of malignant mesothelioma on isolated differentiated mesothelial cells in pleural fluids or biopsies. Cilia or secretory granules were found only in metastatic cells. The finding of fibroblastoid cells in a pleural tumor proves its mesothelial origin.

Basement Membrane↗
PubMedDate not supplied

Nitric oxide effects on lung structure and blood oxygen affinity in rats.

Two month-old Wistar rats were exposed continuously for six weeks, either to 2.0 +/- 0.1 ppm nitric oxide (NO) mixed homogeneously with air for tests, or to ambient air for controls. Oxyhemoglobin dissociation curve (ODC), erythrocytic variables, methemoglobin (MetHb) concentration and lung structure, particularly through electron microscopy studies, were investigated each week of exposure. The hemoglobin affinity for oxygen was not modified, probably as a result of both pH and 2,3-diphosphoglycerate (2,3-DPG) stability. Moreover MetHb formation was not found in treated rats. The few ultrastructural alterations found under electron microscopy may not prove NO-induced since they were found similarly in both groups. Slight emphysematous changes were found only in 1 micrometer-thick sections of lungs from NO-treated rats.

Adenosine Triphosphate↗