Unusual complication of sensitizing therapy for alopecia areata.
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Biomedical subjects
Publications and source records attributed to F Bardazzi.
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A 23-year-old girl affected by Papillon-Lefèvre syndrome developed, during Etretinate therapy (1 mg/kg/day), two liver abscesses caused by pyogenic bacteria and a subphrenic abscess. The immunological effects of retinoids may precipitate severe infections in patients with Papillon-Lefèvre syndrome, who probably have a basic, even though not always evident, defect of PMN chemotaxis.
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The audiologic function in 50 patients affected by vitiligo was studied. Eight patients (16%) had sensorineural hypoacusis when first seen by us. The relationships between melanocytes of the inner ear and auditory function are discussed.
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