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Biomedical subjects

F Barbier

Publications and source records attributed to F Barbier.

At least 55 records · Page 3Linked to original sources
PubMed1981

Serum molybdenum in diseases of the liver and biliary system.

We determined the serum molybdenum concentration by neutron activation analysis in apparently healthy subjects and in patients with diseases of the liver and biliary system. The level was found to be markedly elevated in the initial phase of acute viral hepatitis (mean +/- S.D. 3.10 +/- 1.46 ng/ml vs. 0.55 +/- 0.21 in controls) and to return to normal during convalescence, in parallel with the liver function tests. The most significant correlations were found between the serum molybdenum concentration and the serum levels of GOT ( r = 0.710, p less than 0.001) and GPT (r = 0.683, p less than 0.001). Besides, the serum molybdenum level (mean +/- S.D.) was observed to be definitely increased in patients with HBsAg-positive chronic active hepatitis (0.97 +/- 0.49 ng/ml), HBsAg-positive liver cirrhosis (1.01 +/- 0.50), alcoholic liver disease (1.32 +/- 0.56), liver metastases (1.40 +/-0.39), gallstones (1.28 +/- 0.38), tumors of the gallbladder or extrahepatic bile ducts (1.64 +/- 0.44), and carcinoma of the head of the pancreas (1.61 +/- 0.91). Finally, the serum molybdenum level was found to be raised in two patients with primary biliary cirrhosis and in two out of four patients with drug-induced liver injury. The etiologic mechanism and the clinical importance of the observed abnormality remain to be established. Our study enlarges the existing information concerning the disorders of trace element metabolism in liver diseases.

Adolescent↗
PubMed1980

In vitro inhibition of platelet aggregation by bile salts.

In a series of in vitro experiments, the influence of bile salts on platelet aggregation by ADP or by collagen and on serotonin-14C release by collagen, was studied. Sodium salts of the following bile acids showed a clear inhibitory effect: glycochenodeoxycholic acid, taurochenodeoxycholic acid, glycocholic acid, taurocholic acid and cholic acid. Lowering the pH of the platelet-rich plasma resulted in decrease platelet aggregation by ADP and by collagen. Bile salts further enhanced the inhibitory effect of pH change. In contrast the sodium salt of chenodeoxycholic acid was the sole aggregation inducing bile salt we studied. Relating the above studies to the clinical situation of upper gastroduodenal mucosal haemorrhage, we suggest that biliary reflux as well as the acidic environment may contribute to a poor haemostatic response by impaired platelet aggregation in the upper gastrointestinal tract of otherwise normal human subjects.

Adenosine Diphosphate↗
PubMed1980

Quantitative determination of fecal bile acids as their methyl ether methyl esters by the repetitive scan technique.

Quantification of bile acids has been carried out by selected ion monitoring and by repetitive scanning. The latter method has been explored critically and found to be very suitable. A 24 h collection of feces was submitted to Soxhlet extraction. The extract was purified on Servachrom XAD-2, and separated into sulfated and non-sulfated fractions over DEAP-Sephadex-LH20. Conjugated and sulfated bile acids were enzymatically deconjugated and desulfated prior to permethylation. Deuterated bile acid derivatives were added as external standards and an aliquot was injected onto a capillary column of SE-52. The reconstructed chromatogram traces of specific ions were integrated to quantify known bile acids. Spectra of all metabolites were available for identification purposes simultaneously.

Bile Acids and Salts↗
PubMed1979

Testosterone metabolism in normal males and male cirrhotics.

The following physiopathological mechanisms for the abnormalities of testosterone metabolism observed in cirrhotic patients may be postulated: 1. The decreased testosterone secretion has a primary testicular origin; it seems probable that, as a result of direct toxicity the 17-beta-reductase is inhibited, resulting in decrease of testosterone and an increase of androstenedione. 2. The hypothalamic-pituitary function is nearly normal in cirrhotics. Basal level of LH and FSH are often slightly elevated, indicating a normal reactivity of the pituitary. 3. The conversion of androgens to oestrogens (androstenedione to oestrone) which occurs essentially extrahepatically, is increaed in cirrhosis.

Adipose Tissue↗
PubMed1978

Determination of molybdenum in human serum by neutron activation analysis.

Several investigators have reported serum molybdenum determinations in healthy humans. However, their results diverge quite widely. We determined the element by neutron activation analysis in 30 individuals. We found a mean value of 0.58 ng/ml, a standard deviation of 0.21 ng/ml and a range of 0.28--1.17 ng/ml.

Adolescent↗
PubMed1978

[Not Available].

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France↗
PubMed1978

Determination of chromium and cobalt in human serum by neutron activation analysis.

Confusion exists about the chromium and cobalt concentrations in the serum of healthy individuals. We determined these elements by neutron activation analysis. The samples were irradiated during 12 days at a flux of approximately 10(14) neutrons.cm-2.s-1. Chromium was selectively separated by distillation after the irradiation. We obtained the following values (mean +/- standard deviation): 0.160 +/- 0.083 mug/liter for chromium, and 0.108 +/- 0.060 mug/liter for cobalt.

Blood↗
PubMed1978

Jejunal bile salts and microflora in patients with partial gastrectomy.

Bile acids and microflora were studied in the proximal jejunum in 31 patients with Billroth I or II gastrectomy. At least 10(5) bacteria/ml., most frequently aerobic or facultative aerobic organisms, were isolated in 25 patients. Deconjugation diminished considerably in only three of seven patients with bile salt deconjugation treated with clindamycin. The relationship between bacterial overgrowth, deconjugation, steatorrhea, cholesterolemia and the relationship between bile salt concentration after testmeal and steatorrhea, are discussed. Bacterial overgrowth and bile salt deconjugation are only minor causes of steatorrhea in this series.

Adult↗