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Biomedical subjects

F Barale

Publications and source records attributed to F Barale.

At least 73 records · Page 4Linked to original sources
PubMed1986

[General anesthesia and preoperative changes in plasma beta-endorphin].

The variations of plasmatic beta-endorphin and cortisol levels are studied in 3 groups of patients. These subjects are submitted to abdominal surgery following 3 different anaesthetic schemes: neuroleptanalgesia (droperidol and fentanyl), pure analgesia (fentanyl), association halothane - small dose of fentanyl. The study covers the period from premedication through recovery. The results of this work demonstrates that the average level of beta-endorphin in neuroleptanalgesia and pure analgesia series is stable; there is an increase in the halothane series just after the incision until waking up. The average level of cortisol is stable for the 3 series until incision. It is strongly increased in the neuroleptanalgesia series and in the halothane series. This increase is delayed and reduced in the fentanyl series.

Adult↗
PubMed1986

[Action of ifenprodil tartrate in obliterative arteriopathies of the lower limbs. Combined studies using proximal blood flow and distal transcutaneous oxygen pressure].

A simultaneous analysis of both the variations of the flow in the stenosis artery and the distal PO2, was carried out during an injection of an alpha-blocker: the Tartrate d'Ifenprodil, on twenty-five patients afflicted with occlusive disease of the lower limbs requiring surgery. The measurements were taken under general anaesthesia, before any surgical operation, the hemodynamic and ventilatory balance being monitored by radial manometry and arterial gas analysis. We observe an increase of proximal arterial flow and at the same time an improvement of the distal TcPO2. Moreover, the variations of microcirculation flow measured by TcPO2 are correlated with proximal flow variations, this relation: delta TcPO2 = K delta Q + A is more true in the first and the second stages of Fontaine. With the same (Tartrate d'Ifenprodil) posology, the distal benefit measured by transcutaneous oximetry is less important in advanced stages compared with other stages (everything else being equal). The transcutaneous measurement of the distal oxygen pressure, allows an objective view of microcirculatory improvement obtained by a vasoactive substance (ifenprodil tartrate) considering the specific nature of each patient arteriopathy.

Adult↗
PubMed1986

[Filter circuits and pollution].

The contamination of air of a 50 m3 operating room has been analyzed after three and half hours of halothane enaesthesia with a closed circle system and an opened system. The analysis has been made by gaz chromatography. Concentrations of Halothane found during the use of an opened system are 100 to 120 times the allowable norms in U.S.A. After using the closed circle system, the analysis of air does not reveale any trace of Halothane.

Air Pollution↗
PubMed1985

[Epidemiologic characteristics of 21 peranesthetic anaphylactoid accidents observed in a population of 12,855 surgically treated patients].

A study of anaphylactoid reactions (AR) observed between September 1982 and September 1983 was carried out in the surgical departments of a French regional hospital. The patients who had presented clinical symptoms suggesting an AR (bronchospasm, collapse, tachycardia, with or without skin rash) during a general anaesthesia were included in this study. A precise history of previous anaesthesias and allergy was taken; allergological testing was carried out six to eight weeks after the AR. It included intradermal skin tests (ST) and a human basophil degranulation test (HBDT) with the suspected drugs. Out of 12,855 patients operated on under general anaesthesia in the hospital, 21 AR were seen during the year under study, in 18 women and 3 men, of median age 27 years (extreme values: 11 and 62). The median number of previous anaesthesias was 2 (extreme values: 0--in 4 cases- and 22). Cardiocirculatory abnormalities were the most frequent clinical symptoms of the AR: they consisted of decreased arterial pressure in 13 cases, with 8 cases of vascular collapse. Respiratory symptoms were less frequent but severe bronchospasm was observed in 5 cases. Skin rashes were seen simultaneously in 13 out of the 21 observations. A history of allergy was found in 11 patients. Total IgE serum concentration averaged 134 kU X 1(-1) (extreme values: 32-378). Results of histamine-sensitivity skin tests were not significantly different from those observed in a control group. Calcemia and magnesemia were in the normal range. One to four drugs were tested in each patient: 41 tests combining ST and HBDT were carried out.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1984

[Hypocaloric nutrition or strict protein intake in the postoperative period].

The purpose of this study was to verify the statements of Blackburn concerning the positive effects of strict nitrogen hypocaloric diets. Three groups of 10 postoperative patients received hypocaloric diets. A carbohydrate diet of 200 grams was given to the first series of patients, a nitrogen diet of 12.4 to the second and finally a carbohydrate-protein diet consisting of 200 grams Sorbitol and 12.4 grams nitrogen to the third. Patients were followed for five days. The existence of post-aggression reactions was determined through measurements of GH, Cortisol, glycemia, insulinemia, fatty acids and ketone bodies. Patients under the strict nitrogen diet presented a less elevated hyperglycemia than the other groups. Insulinemia was also lower with values returning to normal by the second day. This same group showed a significant rise of free fatty acids with ketonemia, an obvious sign of lipolysis. The respiratory quotient, near 0.7, was also indicative of lipolysis. The cumulative nitrogen balance over five days was much less negative than for patients under a strictly carbohydrate diet: the nitrogen balance closest to zero was however obtained for patients under the carbohydrate-protein diet. The combined analysis of the respiratory quotient and the nitrogen balance allowed an evaluation of the respective participation of lipid and carbohydrate nutriments to the energy supply in function of the three types of diet. Lipid participation was of 36% under the carbohydrate diet, 48% under the carbohydrate-protein diet and 84% under the strictly protein diet.

Blood Chemical Analysis↗
PubMed1983

[Deliberate poisoning with paraquat, death in less than 24 hours].

This paper describes a case of deliberate massive ingestion of Paraquat (over 300 mg/Kg). Evolution is toward a circulatory insufficiency with metabolic acidosis, hyperglycemia, and early death (18 hours). Severe pulmonary failure would have been expected, but not appeared. Autopsy revealed patchy necrosis of the liver but no severe damage of the other organs, including lung and adrenal.

Acidosis↗
PubMed1983

[Severe respiratory complications in acute voluntary drug poisoning. Apropos of 15 cases in 824 poisoning cases].

Respiratory diseases are the most heavy complications that we can meat in self-poisoning persons. Authors report 15 cases of respiratory complications appeared in 824 self-poisoning cases by drugs. Different factors involved in respiratory diseases origin are analysed but only one appears to be significant: the time between poisoning and admission in intensive care unit. The encountered complications are: acute respiratory distress syndrome, Mendelson syndrome, heavy pulmonary infections, pulmonary embolism. Authors argue about the means of prevention. This seems the fundamental aspect, alone capable to decrease the incidence of very heavy complications responsible of a height mortality range (33%).

Humans↗
PubMed1982

[Haemoperitoneum due to ruptured hepatoma in a cirrhotic patient with porphyria cutanea tarda. Three years' survival (author's transl)].

A case of ruptured hepatocarcinoma of the left lobe in a cirrhotic patient with a 7 years' history of porphyria cutanea tarda (PCT) is reported. Emergency left lobectomy resulted in 3 years' survival with no sign of recurrence at present. Comments are made concerning the clinical association PCT-hepatoma: (1) either PCT is associated with a hypersecretory hepatoma and behaves as a neoplastic syndrome following the same course as the tumour; (2) or PCT is associated with a cirrhosis (usually alcoholic) which facilitates the development of a hepatoma. In such cases, PCT precedes the tumour and follows a separate course.

Aged↗