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Biomedical subjects

F B Spencker

Publications and source records attributed to F B Spencker.

At least 37 records · Page 2Linked to original sources
PubMed1990

Typing of multiple isolates of coagulase-negative staphylococci from blood cultures and cerebrospinal fluid in neonates and children: an approach to discriminate contaminants.

From eight neonates and children suspicious for suffering from septicemia and/or meningitis, coagulase negative staphylococci (CNS) were isolated from multiple blood cultures and from cerebrospinal fluids originating from different punctures. S. epidermidis was the predominant species. By a further typing using plasmid-profiles and exoprotein patterns besides the resistance phenotype, contaminants could be discriminated from the isolates as the probable etiologic agent exhibiting unique reaction patterns. CNS isolated from cases of septicemia together with other bacterial pathogens or from cases of presumed but not confirmed septicemia revealed as different.

Adolescent↗
PubMed1990

[Development and organization of breast milk collection centers in East Germany].

Human milk banking has a longstanding tradition in the GDR. We report on the main data of a survey carried out in 1987, actualized in 1989. Whereas human milk banking was widespread during the 1950s, it reached it's lowest level in 1972. In 1988 the amount of collected milk was nearly 200,000 litres (60 milk banks). Thus, the supply met the demand approximately. The development of the human milk banks is characterized by an increase of the number of milk banks (mostly the banks are affiliated to a children's hospital) and the collecting capacity. Half of the milk banks carries out the collection on a daily basis. This makes it possible to provide fresh milk with it's clear-cut advantages, especially in immunological respect. Otherwise the milk is stored after boiling, freezing or pasteurization. The feeding of very low birth weight newborns with fresh human milk is steadily increasing with corresponding consequences for the quality control of donated milk and the management of milk banks.

Germany, East↗
PubMed1990

[Bacterial heart diseases in childhood. An overview of diseases 1971-1987].

The authors give a review of patients with bacterial cardiac disease treated in the Paediatric Clinic of Karl-Marx-University Leipzig between 1971 and 1987. During this period 32 patients were observed, which amounts to about 2 to 3 patients per year. The majority of patients had congenital heart disease. Despite antibiotic therapy the prognosis of this infection is still serious: One third of the patients died, and diagnosis is made with considerable delay in some cases. Problems and diagnostic and therapeutic approaches are discussed.

Bacteria↗
PubMed1989

[Infections caused by Candida krusei in newborn infants].

Experiences are described about systemic infections with fungaemia due to Candida krusei in seven newborns treated in a department of neonatology because of several perinatal problems. The origin of this outbreak cold not be established. In six patients the infection was early detected and successfully treated with miconazole and/or ketoconazole, all six newborns recovered. Infections due to Candida krusei are extremely rare in humans. This report demonstrates the clinical picture of this infection in newborns.

Antifungal Agents↗
PubMed1989

[Pneumococcal infections in children: hemolytic-uremic syndrome].

By the example of a case-report diagnostic and therapeutic features of the haemolytic-uraemic syndrome are discussed within the frame of infections by pneumococci. In case of infections by pneumococci but also of those ones caused by other bacteria or viruses neuraminidase may be set free, that on its part may lead to an enzyme-induced haemolysis and in some cases also to a damage of other cell systems. In case of an active share of the kidney a haemolytic-uraemic syndrome may be the consequence.

Hemolytic-Uremic Syndrome↗
PubMed1989

[Clinically relevant pathogens isolated from blood cultures of inpatient treated children (1972 to 1985)].

Blood cultures are extremely useful in diagnosing various bacteremic diseases in childhood. The results obtained in this study are presented in relation to two periods of equal length (1972-1978, 1979-1985). At the present time there are about 22 relevant isolates from blood cultures per 1000 admitted children and year in the Department of Pediatrics, and about 3 isolates per 1000 admitted children and year in the Department of Pediatric Surgery, respectively. From newborns we isolated most frequently E. coli, Staph. aureus, B-Streptococci, Pseudomonas aeruginosa, Klebsiella pneumoniae, and yeasts. From children beyond the first month of life Haemophilus influenzae, Streptococcus pneumoniae, other streptococci, Neisseria meningitidis, and Staph. aureus were the most frequent identified etiologic agents. The main factors influencing the spectrum of agents causing bacteremia are: age of patients, status of hospitals, and applicated diagnostic and therapeutic procedures.

Bacteria↗
PubMed1989

[New developments in bedside diagnosis].

The time required to isolate microorganisms, identify them, interpret results, and provide guidance for therapy is inordinate for urgent decisions in primary care. The emphasis for a more rapid diagnosis bedside or in the office, respectively, is caused apart from medical reasons by economic restrictions necessitating earlier diagnosis, more immediate and appropriate treatment, shorter patient hospital stays, and allowing the patient to resume normal productivity earlier. After describing some general criteria with regard to the design of tests for bed-side diagnosis we discuss well known and novel procedures: microscopy of clinical specimens, microbial antigen detection, and nucleic acid hybridization. In concluding remarks we underline the necessity of careful clinical studies concerning sensitivity, specificity, and reliability as well as quality control measures for every novel assay before and during introduction in clinical and office practice.

Bacteria↗
PubMed1989

[Pneumococcal infections in children: osteomyelitis and arthritis].

A pneumococci-osteoarthritis in 8 children is reported on. In almost all the cases an adequate therapy (antibiotics, immobilization, physical therapy) resulted in a healing process free of defects with a full maintenance of the articular function. Besides by staphylococci and haemophilus influenzae, pneumococci too use to play a role as pathogenic organisms for osteomyelitis and arthritis.

Arthritis, Infectious↗
PubMed1988

[Staphylococcal endocarditis in the mitral valve prolapse syndrome].

A girl, aged 13 8/12 years, in whom has been known a syndrome of the mitral valve prolapse since the 10th year of age, fell ill with an acute endocarditis by staphylococcus aureus. As the therapy with antibiotics remained without any effects and due to an early embolic dispersion including the brain an operative approach was no more possible death occurred. The pathologic-anatomical investigations resulted in a distinct ulceropolypous endocarditis of the mitral valve. At the instance of this case report the most important facts nowadays known about the relation between the syndrome of mitral valve prolapse and endocarditis are summed up.

Adolescent↗
PubMed1988

[Listeriosis of the central nervous system in children beyond the neonatal period].

Observations on three children with neurolisteriosis (one case of meningitis, two cases of meningoencephalitis, each Serovar 4 b), show that even after the neonatal period, listeriosis must not be ignored in the process of diagnosis and therapy. It is the bacteriological examination of the cerebrospinal fluid, together with the blood culture, and not clinical symptoms and serology that guarantee a timely diagnosis and therapy (ampicillin and gentamicin).

Anti-Bacterial Agents↗