Dr. Muriel M. Gardiner: psychiatrist and philanthropist.
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Biomedical subjects
Publications and source records attributed to F B Rogers.
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Ninety-seven traumatized patients had blood samples taken immediately upon admission before any resuscitation. Microaggregate (MA) formation was measured by the screen filtration pressure (SFP) technique. Plasma fibronectin levels (Fn) were measured by immunoturbimetric assay. An Injury Severity Score (ISS) was calculated for each patient. The results show a highly significant correlation between severity of trauma, amount of MA formation, and amount of Fn depletion. We conclude that the highly significant correlation between MA formation and Fn depletion following trauma suggests a role for the reticuloendothelial system (RES) in the clearance of MA that form following trauma. Further, enhancement of RES clearance of MA may be possible by purified Fn or cryoprecipitate administration early in the treatment of trauma patients, thereby preventing the adverse sequelae of end organ MA deposition.
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Of fatally injured patients with non-CNS injuries reaching the ER alive in an entire state from 1975-1979, 22% were judged to have potentially survivable injuries. A previous study from 1969-1974 in the same state of fatally injured abdominal injury patients showed 26% potential survivors. Errors in initial volume replacement, airway-respiratory control, and in the recognition of surgical urgency stand out in the present series. Review of these cases suggests that stabilization and resuscitation are necessary before transfer and that bypass to a regional trauma center would not have been likely to be effective in such a rural state.