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Biomedical subjects

F B Bang

Publications and source records attributed to F B Bang.

At least 55 records · Page 3Linked to original sources
PubMed1974

Acute Newcastle viral infection of the upper respiratory tract of the chicken. I. A model for the study of environmental factors on upper respiratory tract infection.

Acute Newcastle disease virus infection following intranasal inoculation of chicks with a mesogenic strain of the virus produced a localized infection of the middle turbinate which was histologically demonstrable 18 hours after inoculation. There was destruction of mucous cells of individual acini in the under surface of the middle turbinate, and the infection rapidly spread to ciliated and goblet cells and to neighboring acini. By day 2 there was simultaneous remodeling of the mucosa, continued destruction and inflammatory infiltration and frequent loss of cartilage basophilia. By day 3 polymorphonuclear cells almost disappeared, epithelial mitoses commenced, and lymphocyte infiltration intensified; the plasma cells normally present along the lateral nasal gland ducts were often destroyed, very occasionally the glands themselves were destroyed. By days 5 and 6 inflammation greatly decreased, and by day 8 the mucociliated epithelium was essentially normal. The infection is sequentially comparable to acute mild rhinitis of man.

Administration, Intranasal↗
PubMed1972

Hemagglutination assay of antibodies associated with pulmonary acariasis in rhesus monkeys (Macaca mulatta).

Antibodies associated with infection by lung mites (Pneumonyssus simicola) in rhesus monkeys were measured by passive hemagglutination methods. Tanned human Rh negative O red blood cells or sheep red blood cells coated with soluble acarine antigens were used to detect mite-specific antibodies. Large quantities of host-specific mite antigens (P. simicola) were difficult to obtain, so free-living mite species such as Dermatophagoides farina, Acarina sheldonii, and Tyrophagus putrificiensis were also utilized. Although the best serological specificity and sensitivity were obtained with P. simicola and its derivatives (1:640), several free-living acarine species were useful in detecting antibodies to mites. Skin tests carried out on a limited number of animals were positive for both immediate and delayed hypersensitivity.

Age Factors↗
PubMed1972

Lymphocyte depression induced in chickens on diets deficient in vitamin A and other components.

Chickens maintained from time of hatching to age of 30 days on a diet lacking vitamin A, and on 2 diets lacking vitamin A and other nutritional components showed depletion of lymphocyte and plasma cell populations in nasal, paranasal and bursal lymphoepithelial tissues. Effects were significant with all diets but most severe with the most deprived diet. Infection of these birds with Newcastle disease virus showed further depletion of plasma cells, subnormal inflammatory response, keratinization of bursal epithelia and postsloughing metaplasia of nasal mucociliated epithelia. The bursae of infected chickens on the diet lacking only vitamin A were completely devoid of lymphocytes 6 days after Virus inoculation. Infected chickens on the most deprived diet showed atrophy of areas of intranasal epithelia which indicated failure of basal cells to synthesize replacement cells.

Animals↗
PubMed1972

Mucous hypersecretion induced in isolated mucociliated epithelial cells by a factor in heated serum.

A factor in the serum of the marine coelomate, Sipunculus nudus, induced by injecting a mixture of a marine bacterial vibrio and a solution of dried cholera toxin, will, after heating to 85 to 90 C, cause intensive continuous hypersecretion of mucus in isolated free-swimming mucociliated cells from another Sipunculus. The factor, released from coleomic cells into the serum, is heat stable to 90 C, withstands several freeze-thawings, is induced only by specific stimuli, is rapidly released into the serum, persists for different time spans depending on the stimulus, and is not present in normal heated sera. It is proposed that in nature this factor is balanced by a heat labile inhibitory factor. Cholera toxin alone is a feeble stimulus. The marine vibrio alone is a powerful stimulus to mucus secretion but lethal for the host. In combination with cholera toxin, the vibrio is nonlethal.

Animals↗
PubMed1971

Transmissible Disease, Probably Viral in Origin, Affecting the Amebocytes of the European Shore Crab, Carcinus maenas.

A transmissible infection of the shore crab ("crabe enragée"), Carcinus maenas, was discovered in one of about 700 of this species collected by the Station Biologique, Roscoff, France. The infection has been transferred by subinoculation through four serial passages in crabs collected at Roscoff and through six more passages in C. maenas collected at Woods Hole, Mass. The agent causes abnormal cellular clotting, a drop in the peripheral amebocyte count, clumping of amebocytes in the peripheral tissue and blood, and abnormal behavior of the amebocytes of the infected animal on glass. Mortality over a period of some weeks is negligible. Electron microscopy shows characteristic virus particles, about 55 to 125 nm in size, in the infected amebocytes. The agent is present in large amounts in the whole blood and serum, is filterable, heat labile, and has been preserved in the frozen state. Final identification will depend upon purification, growth in tissue culture, and further electron microscopy.

Journal Article↗