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Biomedical subjects

F Aubin

Publications and source records attributed to F Aubin.

102 records · Page 6Linked to original sources
PubMedDate not supplied

[Iatrogenic acrodermatitis enteropathica-like syndrome in leucinosis].

INTRODUCTION: Leucinosis (maple syrup urine disease) is a metabolic disorder caused by an enzymatic deficiency involved in the degradative pathways of the three branched-chain amino acids. We report an observation of acrodermatitis enteropathica-like syndrome induced by essential amino acid deficiency in a child with leucinosis. CASE REPORT: A child with leucinosis was referred to our hospital for exfoliative dermatitis of the perioral and anogenital regions associated with diarrhea and pancytopenia. The diagnosis of iatrogenic acrodermatitis enteropathica-like syndrome was confirmed after screening showing isoleucine deficiency. Rapid response was observed after adequate isoleucine supplementation. DISCUSSION: The acrodermatitis enteropathica-like eruption in our patient was due to an iatrogenic amino acid nutritional imbalance. Our observation underlines the risk of using a branched-chain amino acid-free formula without adequate supplementation of deficient amino acids. In addition, dietary insufficiency of isoleucine, associated with the treatment of organic aciduria should be added to the causes of acrodermatitis enteropathica-like syndrome.

Acrodermatitis↗
PubMedDate not supplied

[Toxocariasis].

A COSMOPOLITAN PARASITIC ZOONOSIS: Toxocariasis is a widespread native parasitosis. It is due to the presence of Toxocara-type nematode larvae in the organism, that is at the origin of various clinical pictures. Transmitted by dogs and more rarely by cats, contamination occurs by ingestion of embryos deposited on the ground (animal excrements). MULTIPLE CLINICAL FORMS: The clinical forms are non-specific but frequent and varied (neurological, ophthalmologic, pulmonary, cutaneous and sometimes rheumatological). DIAGNOSIS: Diagnostic presumption is made in the presence of hypereosinophilia, proof of progressing toxocariasis. However, this increase is non-specific and is found in many other parasitosis. Diagnosis should therefore be confirmed using an IgG ELISA test and confirmed by Western Blot. TREATMENT: Currently, there is no consensus regarding treatment, however certain data are available in the literature. Prophylaxis appears to be the best weapon against this little known disease.

Animals↗
PubMedDate not supplied

[Herpes gestationis. Apropos of 2 cases].

Herpes gestationis is an autoimmune disorder specific of pregnancy. The authors report two cases of this condition with distinctive clinical and immunological features. Both the pathogenesis and the nosologic connections between Herpes gestationis and Bullous pemphigoid are reviewed and discussed.

Adult↗
PubMedDate not supplied

[Incontinentia pigmenti. Apropos of a new case].

This paper describes a new case of Incontinentia Pigmenti in a newborn. This genodermatosis develops mostly in females and three clinical stages are recognized. Other ectodermal abnormalities may be associated with a risk for the prognosis. The clinical, histological features and differential diagnosis are discussed.

Abnormalities, Multiple↗
PubMedDate not supplied

[Double-blind randomized comparative study of nicergoline naftidrofuryl on the quality of life in chronic obliterative arteriopathy of lower limbs with intermittent claudication].

The functional limitation of patients with obliterative arterial disease, and with intermittent claudication, damages their quality of life. The purpose of this trial was to compare the effects of nicergoline and naftidrofuryl on the quality of life and the functional discomfort of the 131 patients with claudication. It was a multicentre, randomised, double-blind trial with parallel groups. The patients were asked to complete a quality of life questionnaire and a Visual Analogue Scale, and to evaluate the number of steps on flat ground before the pain began. After 6 months of treatment, we observed, for all treatments combined, a significant improvement (p = 0.0001) in the quality of life and in the functional discomfort. Three variables favoured nicergoline: the estimated time before the onset of the pain (p = 0.003), the functional discomfort quantified by the Visual Analogue Scale (p < 0.05), the distance covered on flat ground (p = 0.013). The other variables, and especially the total score on the self-questionnaire, confirmed this impression, without reaching significance (p = 0.136). The data suggest that in terms of quality of life nicergoline is superior. The clinical tolerance is good and comparable between the two treatments.

Adult↗
PubMedDate not supplied

Sweet's syndrome associated with cutaneous T cell lymphoma.

Although the association of Sweet's syndrome with haemoproliferative disorders or solid malignant tumors is well known, only two previous observations associated with T lymphoma have been reported. We report the first observation of Sweet's syndrome associated with cutaneous T cell lymphoma. The role of a cytokine cascade released by an abnormal T cell clone is discussed as an initiating event responsible for secondary infiltration with neutrophils.

Aged↗