Twenty-one unrelated Caucasian patients with Primary Biliary Cirrhosis were typed for HLA-A, B, C and HLA-DRw antigens. The antigens HLA-Al, HLA-B8 and HLA-DRw3 were found in increased frequency in relation to the control group. When the P values were corrected for the number of antigens tested only the increase of HLA-DRw3 remained significantly different from the control group (P crr. < 0.004). The antigen HLA-DRw3 was carried by 12 out of 21 patients (57.1%) in comparison to 11 out of 74 (14.8%) normal unrelated Caucasian subjects.

Autoimmune Diseases↗

PubMed1974

[Mitral insufficiency as a result of sail perforation due to bacterial endocarditis (author's transl)].

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Adult↗

PubMedDate not supplied

Clinical and EEG sleep changes in primary dysthymia and generalized anxiety: a comparison with normal controls.

All night EEG sleep recordings and clinical assessments of sleep quality were performed in normal controls, patients with generalized anxiety disorder and primary dysthymia. Patients were selected according to DSM-III R. Changes of sleep architecture, namely a reduction of slow wave sleep, are similar in generalized anxiety and dysthymia. Also the two groups do not exhibit the REM sleep disturbances usually observed in affective illness. Duration and continuity measures are unchanged in dysthymics, but anxious patients show some features of insomnia. The analysis of subjective aspects of sleep showed no relevant differences between the two groups of patients. Using a conventional set of EEG sleep parameters, primary dysthymia seems closer to anxiety disorders than to affective illness. However, the reduction of slow wave sleep in dysthymics and anxious patients may have different pathogenic meanings and the analysis of nonconventional sleep parameters may prove useful in this regard.

Adult↗

PubMedDate not supplied

[Anticipation and quality of life in depression: 2 cognitive concepts?].

This study purports to investigate the relation between negative predictions and quality of life occurring in dysthymia and non-melancholic depression according DSM-IV, in the absence of any personality disorders. The relation between anticipation and quality of life (QoL) is also examined. The results suggest that both anticipatory cognitions and the QoL discriminate the two depressive entities and may have some nosological prediction potential. It is curious to observe the similar behaviour of the two concepts, anticipation and QoL, when implemented with the chosen scales. Moreover, their strong mutual correlation suggests a conceptual proximity or even a concurrent criteria validity. In conclusion, the possibility that both concepts belong to a cognitive sphere should not be ruled out.

Cognition↗

PubMedDate not supplied

[Sleep disturbances in patients with generalized anxiety: a clinical and EEG sleep study].

All night EEG sleep recordings and clinical evaluations of sleep were performed in order to compare patients with generalized anxiety and normal controls. Patients were selected according to DSM III-R criteria and went through a two weeks phase treatment with placebo before the sleep evaluation. As compared to normals, anxious patients showed a fragmented and superficial sleep with no changes of REM sleep features. Further to disturbances of sleep continuity and duration, they had a higher percentage of wake and stage 2, as well as a reduction of slow wave sleep (SWS) mainly due to a diminished percentage of stage 4. Several EEG sleep measures--related both with the amounts of SWS and sleep duration and continuity--are significantly correlated with symptoms severity. The pathogenic significance of sleep disturbances in generalized anxiety is discussed.

Adult↗

PubMedDate not supplied

[Left ventricular function in pure mitral stenosis (1)].

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Adolescent↗