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Biomedical subjects

F Antunes

Publications and source records attributed to F Antunes.

65 records · Page 4Linked to original sources
PubMed1991

[Therapeutic perspectives of HIV infection and of opportunistic infections. Multicenter projects of clinical investigation in the EEC].

Some centers in Portugal involved in the treatment of AIDS patients collaborate in clinical research programmes at a European level. The European Network for the Treatment of AIDS (ENTA) is a concerted action, with logistical and political support from the European Community. Four prospective European multicentre trials on opportunist infections in AIDS patients, have been implemented since the beginning of the ENTA, and 45 European centres, belonging to 11 countries, including Portugal, are so far involved in the present Trials in the Treatment and Prophylaxis of Tuberculosis and Toxoplasmosis. EUROAIDS is another concerted action whose aim is a retrospective study on opportunist infections and cancers related with AIDS registered in several countries in Europe, from 1979 to 1989, and correlate these data with demographic and clinical aspects. Another multicentric trial on antiretroviral treatment, The Iberian ddI study, started and several Spanish and Portuguese centres enrolled patients in this study.

European Union↗
PubMed1985

Serologic diagnosis of toxoplasmosis in experimentally infected pregnant goats and transplacentally infected kids.

Eight pregnant goats were inoculated orally with 10 to 1,000 oocysts of Toxoplasma gondii at 83 to 102 days of gestation. Serum samples from the goats and from the kids born to them were analyzed, using the Sabin-Feldman dye test (DT), a commercially available modified agglutination test (MAT), and a latex agglutination test. Six of the does were observed for greater than 1 year; during this time, they delivered twice. All does developed DT and MAT antibody titers of greater than or equal to 1:2,048 within 29 days after inoculation, and the high titers persisted through the 2nd pregnancy; therefore, serologic results alone should not be relied on for the diagnosis of T gondii-induced abortion in does. On the other hand, all transplacentally infected kids had DT or MAT antibody titers of 1:2,048 before ingesting colostrum, indicating the usefulness of serologic evaluation of the fetus or stillborn kid in the diagnosis of abortion. Antibody was not found in the sera of noninfected kids born to Toxoplasma-infected does. The passively acquired colostral antibody declined by 5 months. Therefore, specific antibody found in adult goats is probably actively acquired. The commercially available MAT was simple, sensitive, and reliable for the diagnosis of caprine toxoplasmosis. The latex agglutination test needs further improvement, as titers rarely exceeded 1:256.

Agglutination Tests↗