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Biomedical subjects

F Antoni

Publications and source records attributed to F Antoni.

At least 145 records · Page 8Linked to original sources
PubMed1975

The mutagenic effect of pesticides on Escherichia coli WP2 try.

Thirty pesticides commercially available in Hungary and three well-known chemical mutagens were applied to agar plate cultures of her+ and her- derivatives of Escherichia coli WP2 try- strain. After incubation, the plates were examined for a relative increase in reverse mutation number. N-Trichloro methylthio-1,2,3,6-tetrahydrophthalimide, dimethyl-3,2-dichlorovinyl-phosphate and N-trichloro methylthiophyhalamide proved to have definite mutagenic activity.

Acridines↗
PubMed1975

A "cytotoxic" factor released from unactivated human lymphocytes.

A protein mixture named LTx, was released from human tonsillar lymphocytes, when incubated at 37 degrees C in either "individual" or "mixed" cultures. LTx caused a decrease in the incorporation of 14C-labelled amino acids of the target lymphocytes, while the release of 51Cr from labelled target cells increased. Target cells were found to bind the "toxic" protein.

Amino Acids↗
PubMed1975

Inhibitory effect of prostaglandin E2 on the incorporation of 3H-thymidine into the DNA of thymus cells.

When rat thymic cells suspended in a simple salt-glucose-albumin medium were incubated with 10 mug/ml Prostaglandin E2 (PGE2) an inhibition of incorporation of 3H-thymidine into DNA was observed. PGE1 had a similar effect, while PGB2 and arachidonic acid proved to be ineffective. This inhibitory effect of PGE2 could be detected after a lag period of about 30 min but in the second hour of incubation the rate of incorporation of 3H-thymidine decreased to about 60 per cent of the control value. The extent of inhibition was found to be proportional to the log10 of the PGE2 concentration. Autoradiography showed that PGE2 had no influence on the number of DNA synthesizing cells. As an effect of PGE2 an early transient increase in the labeling of thymidine triphosphate was observed while the levels of labeled thymidine in the cells were not found to be significantly different in the presence of PGE2.

Animals↗