Biomedical subjects

F Altruda

Publications and source records attributed to F Altruda.

56 records · Page 4Linked to original sources

PubMedDate not supplied

Differential transcriptional pattern of the hemopexin gene.

In this paper we have analyzed the expression of the human hemopexin gene in different human tissues and cell lines by using the specific cDNA probe previously isolated. The results show that this gene is expressed in liver and, in lower amount, in hepatoma cell lines but not in kidney, spleen, placental cells, and in HeLa, fibroblast cell lines. We suggest that there must be cell-specific control mechanisms responsible for the specificity of expression. We have also determined, by S1 mapping, that the transcription initiation site in hepatic cells is 28 base pairs upstream from the AUG initiation codon of the hemopexin gene.

Base Sequence↗

PubMedDate not supplied

Ribosome maturation in E. coli.

In vivo and in vitro experiments have shown that processing of ribosomal RNA is a late event in ribosome biogenesis. The precursor form of RNA is probably necessary to speed up the assembly of ribomal proteins. Newly formed ribosomal particles which have already entered polyribosomes differ from mature ribosomes not only in their RNA content but also in their susceptibility to unfolding in low Mg concentration and to RNase attack. Final maturation of new ribosomes is probably dependent on their functioning in protein synthesis. Thus only those ribosomes which have proven to be functional may be converted into stable cellular structures.

Escherichia coli↗