Biomedical subjects
F Alexander
Publications and source records attributed to F Alexander.
Immunohistochemical differentiation of malignant mesothelioma, mesothelial hyperplasia and metastatic adenocarcinoma in serous effusions, utilizing staining for carcinoembryonic antigen, keratin and vimentin.
The cytologic diagnosis of malignant mesothelioma and its distinction from mesothelial hyperplasia and metastatic adenocarcinoma is consistently difficult; tissue studies utilizing the immunohistochemical profiles of carcinoembryonic antigen (CEA) and keratin have demonstrated a reproducible distinction between these tumors. Mesothelium contains vimentin in addition to keratin, but its characterization is hindered by its poor preservation in formalin fixatives; alcohol fixation is far superior. Alcohol-fixed, Papanicolaou-stained smears of serous fluids from five cases of reactive mesothelium, five metastatic adenocarcinomas and five malignant mesotheliomas were stained with polyclonal CEA, antikeratin monoclonals AE1 and AE3 (combined) and monoclonal vimentin utilizing the peroxidase-antiperoxidase method. The study revealed the excellent preservation of mesothelial vimentin staining in all three groups. The reactive mesothelium and mesothelioma groups were strongly positive for vimentin and keratin whereas the metastatic adenocarcinoma group was only positive for keratin and CEA (except one case). These findings support the results of previous tissue studies, disclosing CEA staining in the metastatic adenocarcinomas, but not in the mesotheliomas, and the inability of keratin staining to distinguish between the two. The findings also emphasize that positive vimentin staining will usually exclude a metastatic adenocarcinoma, but will not distinguish between neoplastic and reactive mesothelial states.
[Double blind study of bronchospasmolytic effect of ucb 1402 in comparison with a placebo].
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Lung function measured with a whole body plethysmograph: standard values for children and young adults.
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[Study on housing conditions of allergic and nonallergic children].
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[The allergic child in a seaside preventorium].
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Circadian heart rate rhythmicity: comparison between an Eskimo and other population groups.
This brief communication reports the results of 24-ambulatory cardiac monitoring of a Bering Strait Eskimo population and compares the findings with 3 other populations. Similar heart rate rhythmicity and almost identical acrophases are found in the Eskimo, Aymara Indian and French populations. However, the Alaskan Eskimo and Aymara Indian 24-h means vary by approximately 15 beats/min, with the American population between these two. The mesor displays most radical differences.