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Biomedical subjects

F Aiuti

Publications and source records attributed to F Aiuti.

At least 253 records · Page 14Linked to original sources
PubMed1977

Preparation, purification and in vitro properties of a serum against human lymphoblastic leukemia-associated antigens.

A serum against human lymphoblastic leukemia cells was obtained inoculating rabbits. We studied the specificity of the serum before and after particular absorptions in various clinical conditions. The serum was cytotoxic against many cases of acute lymphoblastic leukemia, against continuously cultured Burkitt's lymphoma cells and against chronic myelogenous leukemia in blast crisis. On the contrary, the serum was not cytotoxic against lymphocytes of normal donors, acute lymphoblastic leukemia in remission and other lymphoproliferative disorders.

Antibody Specificity↗
PubMed1977

Effect of thymic factor on human lymphoid cells of umbilical cord blood and of children with T cell deficiency.

We report on the in vitro effect of a thymic factor (TF) extracted from pig thymuses, on human lymphoid cells from umbilical cord blood and from peripheral blood of 8 T cell-deficient patients. E rosette formation was not affected by TF when tested on cells from peripheral blood of normal adults. With cells from umbilical cord blood of 13 healthy, full-therm newborn babies, the difference between the percent (mean) of ERFCs before (16.31 +/- 11.13) and after (28.85 +/- 17.10) incubation with TF was statistically significant (p less than 0.05). In most samples, TF transformed about 10-20% of the cells. In the T cell-deficient group the increase in ERFCs of the peripheral blood lymphocytes, though consistent, was variable in degree from case to case. Our data indicate that precursor cells in some individuals with T cell deficiency are very sensitive to TF. Patients with highly responsive precursors appear to be the best candidates for a therapeutic approach with TF when thymus transplant is not possible.

Child↗
PubMed1976

[Personal experiences of immunotherapy using the transfer factor].

Six subjects, four suffering from chronic mucocutaneous candidosis, one from ataxiatelangiectasia and one from partial combined immunological deficiency with ongoing pulmonary tuberculosis, were treated with transfer factor. The deficient immunological situation normalized in all subjects after treatment. Clinically, all showed improvement excepting one candidosis case.

Adolescent↗
PubMed1975

Lymphoid cells in infectious mononucleosis classified according to T and B cell markers.

It has been demonstrated that peripheral blood lymphocytes, particularly the "atypical" ones, are predominantly of the T type in infectious mononucleosis (IM). This is based on membrane marker studies (E rosettes, receptor for complement, receptor for Fc fragment of immunoglobulins (Ig), and membrane Ig) and by anti-T lymphocyte serum. On the other hand, lymphoblastoid cell lines derived from IM patients show the characteristics of B lymphocytes. This permits the suppostion that EBV infects B lymphocytes and stimulates them to proliferate. The cell proliferation is unlimited in vitro and is probably controlled in vivo by T cells. The reduction of cellular immunity in vivo, which contrasts with the high number of T cells in peripheral blood, could be explained by the fact that T cells are engaged in the regulation of B cell proliferation.

Animals↗
PubMed1975

Longitudinal epidemiological survey on hepatitis B-antigen carriers among institutionalized juvenile diabetics.

An epidemiological study was carried out in a juvenile diabetics institution, in order to determine the incidence and the significance of the hepatitis associated Australia antigen (HBAg) carriers. By means of counterelectrophoresis and CF an average of 15% HBAg-positive individuals was found during the course of the search (June 1970-January 1973). As a rule the carrier state appeared to be longlasting and it was only occasionally associated with symptoms and/or signs of liver involvement. Isolation measures to inhibit spread of serum hepatitis (the hepatitis most associated with HBAg) failed partially to prevent the spread of the HBAg associated agent suggesting that nonparenteral transmission could play a role in the diffusion of the infection.

Adolescent↗
PubMed1975

Thymus transplantation. Reconstitution of cellular immunity in a four-year-old patient with T-cell deficiency.

The case is reported of a 4-year-old girl affected with recurrent infections; anaemia, thrombocytopenia, haemorrhages and hepatosplenomegaly. Immunological investigations revealed a defect in cellular immunity related to the thymus-dependent system, hypergammaglobulinaemia (especially of class IgE), and very high titres of antibodies against Epstein-Barr virus (EBV). After foetal thymus transplantation, correction of the immunological defect and significant clinical improvement were noted, as well as a decrease of IgE and EBV antibody titres.

Candida albicans↗