Hemorrhagic infarction.
Explore the source record for details and available documents.
Cerebral Hemorrhage↗
Biomedical subjects
F Ahmed
Publications and source records attributed to F Ahmed.
Role of radioiodine in management of thyroid cancer: experience with 70 cases.
Results of 70 cases of differentiated thyroid carcinoma managed with I131 and surgery have been reported. These results add to the body of knowledge that already exists in the field of treatment of thyroid cancer with radioactive iodine. These results also indicate that the success of radioiodine therapy depends on adequate surgical removal of the thyroid tissue.
Adenocarcinoma↗
Nutritional situation of Dhaka.
The paper presents the nutritional situation of Dhaka. Dhaka is the capital city of Bangladesh with an area of 414 square Km. The population size of Dhaka city is about 7 millions of which nearly 3 millions live in the slums. Socio-economic and socio-cultural situation has been discussed. In the pre-school children, protein-energy malnutrition (PEM) appeared to be a serious problems. A high rate of advanced vitamin A deficiency along with severe PEM has been demonstrated. A recent survey showed that slum children below five years of age had higher prevalence of acute (11%) and chronic (50%) malnutrition. This paper also discussed the nutritional status of school children and pregnant women. A national nutrition survey revealed that average energy intake by the industrial laborers was only 74% of the daily requirement. To date no data is available on the nutritional situation of the adolescent and elderly people. Poverty, lack of knowledge, illnesses, lack of sufficient services and socio-cultural barriers are the major causes of nutritional problem. There are several Government and Non-Government organizations in Dhaka city working for improving community health and nutritional status through a number of interventions; such as health and nutrition education, vitamin A capsule distribution, immunization, growth monitoring and feeding through rehabilitation centers. A positive impact of vitamin A oral dosing has been demonstrated and improved nutritional status by nutrition education and feeding through the centers have been reported. Community participation and sustainability of the program have also been discussed.
Aged↗
Community-based evaluation of the effect of breast-feeding on the risk of microbiologically confirmed or clinically presumptive shigellosis in Bangladeshi children.
To assess the association between breast-feeding and the risk of microbiologically confirmed or clinically presumptive shigellosis, the authors performed a case-control analysis of Bangladeshi children younger than 3 years of age who were followed up for 1 month after exposure to Shigella in their residential neighborhoods. Two hundred sixty-nine cases with culture-confirmed shigellosis (n = 119) or clinically presumptive shigellosis (culture-negative dysentery, n = 150) were compared with 819 controls without Shigella diarrhea or other invasive diarrheal illnesses. The odds ratio relating breast-feeding to confirmed or presumptive shigellosis, adjusted for potentially confounding variables, was 0.48 (95% confidence interval = 0.32 to 0.72; P less than .001), suggesting a substantial protective effect. The protective association decreased with age but was still significant during the third year of life; appeared to be directly related to the degree of stunting; and was equivalent for confirmed and presumptive shigellosis. Notably, the protective association remained substantial against episodes due to Shigella which were resistant to at least one of the antibiotics customarily used for treatment of Shigella diarrhea (age-adjusted odds ratio = 0.40; 95% confidence interval = 0.22 to 0.74; P less than .01). These data suggest that breast-feeding confers a high level of protection against shigellosis throughout the first 3 years of life, especially among nutritionally compromised children, and thereby underscore the importance of promotion of breast-feeding as a central component of Shigella control programs in less developed settings.
Age Factors↗
Effect of family size and income on the biochemical indices of urban school children of Bangladesh.
The relationship between family size and income and the biochemical indices of 242 children (aged from 5 to 12 years) from five schools in Dhaka City, Bangladesh, was investigated. Socio-economic data were collected by questionnaire and blood samples were drawn by visiting each school on a prefixed date. Mean levels of all measures, except for serum zinc, fell within the normal range. Older boys, but not girls (10-12 years of age) had statistically significantly higher haemoglobin, serum protein and serum vitamin A levels compared with those of the younger boys (5-9 years of age). The children were divided into three family size groups (small, up to 4 members; medium, 5-7 members; and large, 8 or more) to investigate the effect of family size on the biochemical data. The children from smaller families showed significantly higher levels of haemoglobin and serum vitamin A compared with the children from large families. For serum protein, copper and zinc, there was no statistically significant difference between the children of different family size groups. To analyse the effect of family income, children were divided into three income groups (low, up to taka 2000; medium, taka 2001-4500; and high, 4501 or more). The children from the low family income group had significantly lower serum protein (7.5 g/100 ml) and haemoglobin (13.4 g/100 ml) levels compared with those of the children from the high family income group (for protein, 7.7 g/100 ml and haemoglobin, 14.1 g/100 ml).(ABSTRACT TRUNCATED AT 250 WORDS)
Analysis of Variance↗
Biotype as determinant of natural immunising effect of cholera.
To test the hypothesis that clinical Vibrio cholerae O1 infections protect against recurrent cholera, treated cholera episodes in a rural Bangladesh population of 188,153 people who were followed between 1985 and 1988 were analysed. Of the 2214 people with initial episodes of cholera, 7 had a second episode. The incidence of cholera was 61% lower in subjects who had had an earlier episode than in those without such an episode. Whereas initial episodes of classical cholera were associated with complete protection against subsequent cholera, initial episodes of El Tor cholera were associated with negligible protection.
Adolescent↗
Effect of vitamin A deficiency on the immune response to epizootic diarrhoea of infant mice (EDIM) rotavirus infection in mice.
The effect of vitamin A deficiency on the immune response to epizootic diarrhoea of infant mice (EDIM) rotavirus was studied in mice. The virus was given by oral dosing or by intraperitoneal injection. For oral challenge, weanling mice were fed on either a control or vitamin A-deficient diet ad lib. or pair-fed the control diet to the intake of the vitamin A-deficient group. A fourth group was fed on the vitamin A-deficient diet ad lib. for 10 weeks and then refed the control diet for 2 weeks. On day 77, mice were each given 30 microliters EDIM rotavirus orally and the animals were killed and examined 1 week later. The delayed-type hypersensitivity (DTH) response to picryl chloride was measured as an index of cell-mediated immunity. For intraperitoneal challenge, weanling mice were fed on either the control diet or the vitamin A-deficient diet ad lib. or pair-fed the control diet to the intake of the vitamin A-deficient group. On day 77, mice were each injected intraperitoneally with 30 microliters EDIM rotavirus and 1 week later antibody production was measured. In both experiments the body-weight, liver and serum vitamin A levels of the vitamin A-deficient group were significantly lower than the control or pair-fed groups. Following oral dosing the serum antibody levels specific to rotavirus were statistically significantly lower in vitamin A-deficient animals than the control or pair-fed groups. Vitamin A-deficient mice also showed an impaired DTH response compared with the control and pair-fed animals. Animals refed vitamin A for a short period showed a partial restoration of the antibody response. Following intraperitoneal challenge no statistically significant changes were observed in the serum antibody levels between any of the dietary groups. It is concluded that vitamin A deficiency impaired antibody production when rotavirus was given orally. Vitamin A deficiency also impaired cell-mediated immunity.
Administration, Oral↗
Field trial of oral cholera vaccines in Bangladesh: serum vibriocidal and antitoxic antibodies as markers of the risk of cholera.
The relationship of serum vibriocidal (VC) and IgG anti-cholera toxin (CT) antibodies to the risk of cholera was evaluated during the first year of follow-up of recipients of three oral doses of B subunit (BS)-whole-cell vaccine, whole-cell vaccine, or Escherichia coli K12 strain placebo in Bangladesh. Acute sera from 121 cholera patients were compared with sera from 2592 contemporaneous community controls. Each doubling of VC titer was associated, on average, with a 22%-47% reduction of cholera risk in the three groups. In contrast, in the two groups that did not receive BS, anti-CT titers were directly associated with cholera and thus served as markers of higher cholera risk. Each vaccine conferred approximately 65% protective efficacy against cholera, but antibody titers did not correlate with vaccine efficacy, indicating that serum VC and anti-CT antibodies are poor markers of the longitudinal pattern of vaccine efficacy.
Administration, Oral↗
ABO blood groups and the risk of diarrhea due to enterotoxigenic Escherichia coli.
To determine whether blood group O persons are at higher risk for enterotoxigenic Escherichia coli (ETEC) diarrhea, a case-control study was done for 17 months among rural Bangladeshis who were under systematic surveillance for diarrhea. Cases were children less than 3 years old who presented between 1 January 1985 and 1 June 1986 for care of heat labile (LT) or heat stabile toxin-producing ETEC diarrhea. Controls were of similar ages and were randomly selected from three community-based serosurveys between July 1985 and May 1986. No association between blood group O and ETEC diarrhea was found for the 510 cases and 641 controls, nor was an association evident for cases of each toxin phenotype. Further refinement of the case definition to include only patients with LT-ETEC diarrhea, without enteric copathogens, also failed to reveal a substantial association with blood group O. These data suggest that a strong association with ABO groups, analogous to that for cholera, does not exist for ETEC diarrhea.
ABO Blood-Group System↗
Antibody responses after immunization with killed oral cholera vaccines during the 1985 vaccine field trial in Bangladesh.
Sera collected during the 1985 oral cholera vaccine trial in Matlab, Bangladesh, which demonstrated efficacy of a whole cell combined with cholera B subunit vaccine (WC/BS) and a whole cell only vaccine (WC), were analyzed for antitoxin and vibriocidal antibodies. Before vaccines were given, antitoxin titers were highest in children, especially those with O blood group, whereas vibriocidal titers rose throughout life. Two weeks after three doses of vaccine, geometric mean antitoxin titers were 2.5-4.5 times higher in vaccinees who received the WC/BS vaccine; the vibriocidal titers were 1.3-2.1 times higher in vaccinees who received either vaccine. The titer elevations were relatively brief and were barely detectable 7 months after the third dose even though significant levels of protection persisted greater than or equal to 3 years. Thus, the oral vaccines induced a serum response in this large field trial that was similar to that seen in earlier pilot studies, but the duration of the serum responses was much shorter than the duration of the protection.
Administration, Oral↗
Culture adaptation and characterization of group A rotaviruses causing diarrheal illnesses in Bangladesh from 1985 to 1986.
Group A rotaviruses collected between 1985 and 1986 during comprehensive surveillance of treated diarrheal episodes occurring in a rural Bangladesh population were culture adapted and characterized by electropherotype, serotype, and subgroup. Of 454 episodes of rotavirus-associated diarrhea, rotaviruses were culture adapted from 381 (84%), and 335 contained 11 electrophoretically identical segments in unpassaged and cultured preparations. These 335 comprised 69 different electropherotypes with between 1 (32 isolates) and 79 representatives. The persistence of specific rotavirus strains within the study population, as defined by the detection of viruses with particular electropherotypes, was generally limited to a period of only a few months. All 335 isolates were serotyped by neutralization with hyperimmune antisera to prototype rotavirus strains representative of serotypes 1 to 4, i.e., Wa, DS-1, P, and ST-3. It was found that 80, 48, 119, and 88 isolates belonged to serotypes 1 to 4, respectively. The concentrations of hyperimmune antisera required to neutralize these isolates, however, were at least threefold greater than those needed to neutralize the homologous strains. Therefore, the isolates appeared to have altered neutralization epitopes from their prototype strains. Furthermore, the serotype 4 isolates were consistently shown to be much more closely related to the serotype 4B VA70 strain than the serotype 4A ST-3 strain. All but two isolates identified as serotypes 1, 3, or 4 had long electropherotypes and were subgroup II, and all but one serotype 2 isolate were subgroup I and had short electropherotypes. The three disparate strains appeared to be genetic reassortants. Evidence is presented that dual infections required for reassortant formation were not uncommon. Thus, formation of multiple reassortants may have been a cause for the observed rapid shift in viral strains within the study population.
Age Factors↗
The effect of caffeine on postprandial blood pressure in the frail elderly.
In a double-blind, random-order, cross-over study the effects of placebo and 100 mg of caffeine on postprandial sitting and erect blood pressure and heart rate were studied in 20 frail elderly subjects (mean age 84, range 75-93 years) after a standardized 400 K-calorie glucose drink. Maximal postprandial reduction in sitting systolic blood pressure occurred, at 60 minutes post-placebo, of - 11 mmHg (95% confidence interval -5 to -17 mmHg, P less than 0.01), and was attenuated by caffeine (P less than 0.05) with changes in systolic blood pressure, at 60 minutes post-drink, of 1 mmHg (95% CI -6 to 7 mmHg, not significant). Four subjects developed symptomatic postprandial hypotension after placebo which was prevented by caffeine. There were no significant changes in erect systolic blood pressure, postural systolic blood pressure change, sitting and erect, diastolic blood pressure and heart rate between treatment phases. Caffeine attenuates the postprandial fall in sitting blood pressure in frail elderly subjects and in particular prevented symptomatic blood pressure reductions in subjects with postprandial hypotension.
Aged↗
Effect of severe food restriction on the gut following rotavirus infection in mice.
The effect of severe food restriction on the histopathology of the gut following infection with epizootic diarrhoea of infant mice (EDIM) rotavirus was studied in mice. Over a period of 12 weeks, weanling mice were fed either 70 or 50% of the diet eaten by a control group on the previous day. After 11 weeks of feeding, animals were given 30 microliters/mouse of EDIM rotavirus orally and the histopathology of the gut and lymphoid organs examined. The histology of the spleen and thymus of different dietary groups appeared normal and no changes were observed due to the rotavirus challenge. Both the control and 70% food group had normal villi in the small intestine. In contrast there was severe atrophy of the villi in the animals whose intake was reduced by 50%. No additional damage to the villi was seen in association with the rotavirus infection. It is concluded that a prolonged, balanced reduction in food intake can itself cause villous atrophy in the gut but following rotavirus infection, adult animals were able to resist further villous damage.
Animals↗
Effect of socio-demographic conditions on growth of urban school children of Bangladesh.
The relationship between socio-demographic variables and growth of 242 school children from five schools in Dhaka city, Bangladesh, was investigated. The socio-demographic data were collected by questionnaire and the anthropometric data were collected by visits to each school on a prefixed date. Children from the high-family-income group showed significantly higher body weight, height, MUAC, SFT, wt/age, and ht/age compared with children from the low-family-income group. When the effect of age, sex, father's occupation and family size were adjusted for by means of multiple analysis of variance, the family income still showed a significant contribution to the variation in the anthropometric indices of these children. These findings suggest that family income makes a significant contribution as a determinant of growth of urban school children in Bangladesh.
Analysis of Variance↗
Local preparation, standardization and quality control of technetium labelled macroaggregated albumin for lung perfusion studies.
Lung perfusion study is an important investigation in various pulmonary diseases. The radiopharmaceutical commonly used now-a- days is imported macroaggregated human albumin (in kit form), which is labelled with technetium (Tc99m-MAA). Due to its high cost the technique could not be fully exploited. We have tried to locally prepare freeze dried MAA particles. Various parameters like concentration of protein, pH value, temperature, quality and quantity of reducing agents were studied to find out the optimum conditions for radiolabelling and the desired particle size. More than 98% of the added radioactivity was found tagged to the MAA particles in the final preparation (confirmed by paper chromatography). Labelled agent was found to be radiochemically stable for up to 6 hours. Initial animal and later human studies showed an ideal spectrum of particle size.
Chemistry, Pharmaceutical↗
Leading causes of infant deaths in the District of Columbia.
Causes of infant deaths were analyzed from the linked vital records of 1988 for the District of Columbia. According to a new cause-of-death classification, 57% of the deaths were attributed to "prematurity and related conditions," as compared with only 31% due to "disorders relating to short gestation and unspecified low birthweight" and respiratory distress syndrome (RDS) in the three-digit ICD-9 classification. Two thirds of infant deaths were "preventable." However, 92% of these occurred to infants weighing less than 1500 g. Not only was a greater proportion of black deaths (71%) preventable as compared to nonblacks (40%), but also 15% of the preventable deaths among blacks were due to causes unrelated to prematurity. The Infant Mortality Rate (IMR) in the District of Columbia would be reduced from 23.2 to 7.7 if all preventable deaths were prevented, to 20.9 if only the preventable deaths not related to prematurity were prevented, and to 15.2 if the percentage of "preventable" deaths among blacks was brought down to the level of nonblacks. Mortality from RDS was substantially higher in the District of Columbia compared with blacks nationally and appeared to offer the best opportunity for reduction. However, detailed examination of circumstances surrounding each infant death would be necessary to inform the strategies for the reduction in IMR.
Cause of Death↗
Field trial of oral cholera vaccines in Bangladesh: results from three-year follow-up.
The protective efficacy (PE) of B subunit killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines was assessed in a randomised double-blind field trial among children aged 2-15 years and women over 15 years in rural Bangladesh. Among the 62 285 subjects who received three doses of BS-WC, WC, or Escherichia coli K12 strain placebo, cumulative PE at 3 years of follow-up was 50% for BS-WC and 52% for WC. PE was similar against severe and non-severe cholera, but was significantly lower in children who were vaccinated at 2-5 years (26% for BS-WC; 23% for WC) than in older persons (63% for BS-WC; 68% for WC). Among persons vaccinated at 2-5 years, protection at 4-6 months of follow-up was similar to that for older persons, but rapidly waned thereafter and was not evident during the third year of follow-up. In contrast, persons vaccinated at older ages were protected even in the third year of follow-up (PE 40% for BS-WC; 62% for WC). PE was substantially higher against classical cholera (58% for BS-WC; 60% for WC) than against El Tor cholera (39% and 40%).
Administration, Oral↗
Unmarried mothers as a high-risk group for adverse pregnancy outcomes.
A total of 36,608 singleton births occurring to Black mothers in the District of Columbia in 1980-84 were examined. Infants of unmarried mothers had a 34 percent higher incidence of low birthweight and a 35 percent higher neonatal mortality rate than infants born to married mothers. To delineate the independent effect of marital status, a logit model was fit to 23,461 births occurring to mothers over 19 years of age. Despite controlling on maternal age, educational attainment and adequacy of prenatal care, the odds ratio for low birthweight was 1.18 for the infants of unmarried mothers. Supplemental analyses showed that if mothers were drug addicted or had their first delivery before age 18, the marital status differentials in the birthweights of their infants were no longer significant. These results indicate the importance of unmarried status as a demographic risk factor, and the need for discerning specific high-risk behaviors associated with life styles of unmarried mothers.
Adolescent↗