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Biomedical subjects

F Abe

Publications and source records attributed to F Abe.

At least 145 records · Page 8Linked to original sources
PubMed1993

Benastatins C and D, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities.

Benastatin C, a new member of the benastatins, has been isolated from the culture broth of Streptomyces sp. MI384-DF12. The structure of benastatin C was elucidated as 2-decarboxy-benastatin A by NMR studies. Benastatin D, 2-decarboxybenastatin B, was derived from benastatin B. Benastatins C and D showed inhibitory activities against human pi class glutathione S-transferase (GST pi) and excellent stimulatory activities on the murine lymphocyte blastogenesis in vitro.

Animals↗
PubMed1993

Bequinostatins A and B new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities.

New benzo[a]naphthacenequinone metabolites, designated bequinostatins A and B, have been isolated from the culture broth of the benastatin-producing strain Streptomyces sp. MI384-DF12. The structures of bequinostatins A and B were determined by spectral analyses to be 5,6,8,13-tetrahydro-1,6,7,9,11-pentahydroxy-8,13-dioxo-3- pentylbenzo[a]naphthacene-2-carboxylic acid and 2-decarboxybequinostatin A, respectively. Bequinostatin A showed considerable inhibitory activity against human pi class glutathione S-transferase (GST pi).

Animals↗
PubMed1993

[A case of arteriovenous malformation with cyst formation].

A case of arteriovenous malformation (AVM) with cyst formation is reported. A 14-year-old girl was admitted to our hospital, complaining of headache. On admission, CT scan showed a cystic mass with mural nodule in the right parietal lobe. Contrast enhanced CT scan demonstrated homogeneous enhancement of the nodule. MRI demonstrated the nodule as an area of signal void. Right carotid angiogram showed a typical nidus with feeding artery and draining vein. The nidus was totally removed by the trans-cystic approach. Histological diagnosis was typical AVM with hemosiderin deposits. AVM with cyst formation is very rare, with only six cases having been reported. The mechanism of cyst formation is controversial. Past reports have hypothesized the participation of a massive hemorrhage, or exudative process. Our case showed hemosiderin deposits, but no symptom indicative of hemorrhage. In this case, the etiology of cyst formation was considered to be exudation and thrombosis of the nidus.

Adolescent↗
PubMed1992

High-performance affinity chromatography system for the rapid, efficient assay of glycated albumin.

A high-performance affinity chromatographic system was constructed and shown to permit highly reproducible, rapid, automatic assays of serum glycated albumin (GA) by separation of albumin (Alb) on an anion-exchange column (Asahipak ES-502N) packed with a vinyl alcohol copolymer bearing diethylamino groups and consecutive separation of GA on a column packed with a vinyl alcohol copolymer bearing boronate groups. The first column selectively retained Alb free of other serum proteins and permitted at least a 95% recovery of sample Alb. The purity of the Alb peak was confirmed by two-dimensional electrophoresis. Chromatographic analyses of human serum Alb incubated with glucose on the second column showed that the peak area for GA increased in accordance with the incubation time and suggested selective adsorption of GA on the second column. Optimization of the conditions for the two-column system reduced the analysis time to 10 min. Analyses of human sera with the present system showed GA to be 16.1 +/- 1.1% (mean +/- S.D.) of total Alb in non-diabetic children and 39.9 +/- 9.1% (mean +/- S.D.) in diabetic children (0-17 years old).

Adolescent↗