[A family of hemoglobinopathy detected with high performance liquid chromatography].
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Adult↗
Biomedical subjects
F Abe
Publications and source records attributed to F Abe.
Inclusive Lambda 0 polarization in proton-nucleus collisions at 12 GeV.
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Journal Article↗
Evaluation of positive and negative ion fast atom bombardment mass spectrometry for structural investigations on cardenolide-type cardiac glycosides.
Evaluation of positive and negative ion fast atom bombardment (FAB) mass spectrometry for structural investigations have been studied on 30 cardiac glycosides in comparison with their field desorption (FD) mass spectra. FD mass spectra showed the prominent molecular cluster ions and the same protonation induced fragments as that established for steroid oligoglycosides. Even if the molecular cluster ions of some di- and triglycosides were hardly detected in the positive ion FAB mass spectra owing to their low intensities, a dramatic improvement was observed when sodium chloride or potassium iodide was added to the glycerol matrix. Furthermore, the prominent molecular ion species, [M-H]-, and the sequence of glycosidic linkage were easily detected in the negative mode. The combination of positive and negative ion FAB mass spectrometry of the cardenolide-type cardiac glycosides provides useful information concerning the molecular weight as well as the structures of both aglycone and sugar moieties.
Cardenolides↗
Mucormycosis in diabetic ketoacidosis. Role of unbound iron binding capacity of transferrin.
Increased susceptibility to Rhizopus oryzae in diabetes was investigated using mice in which diabetic ketoacidosis was experimentally induced. All of the diabetic mice which had developed ketoacidosis died within four days after inoculation of R. oryzae and their serum UIBCs (Unbound iron binding capacity) were significantly lower than those of the normal control mice. This study suggested that the decreased serum UIBC produced by diabetic ketoacidosis enhances the growth of R. oryzae in vivo.
Animals↗
Enhancement of graft-versus-host reaction and delayed cutaneous hypersensitivity in mice by ubenimex.
The effect of ubenimex on graft-versus-host reaction and delayed cutaneous hypersensitivity in mice was studied. Ubenimex enhanced the graft-versus-host reaction in a dose range from 0.005 to 0.5 mg/kg. Ubenimex inhibited the aging-caused decrease of delayed cutaneous hypersensitivity to oxazolone and the efficacy was greater with older mice. Ubenimex also inhibited mitomycin C and L1210-caused decreases of delayed cutaneous hypersensitivity to picryl chloride. However, the excess decrease caused by mitomycin C was not significantly altered by ubenimex.
Adjuvants, Immunologic↗
The effect of ubenimex on N-methyl-N'-nitro-N-nitrosoguanidine-induced stomach tumor in rats.
The effect of ubenimex on the progression of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced stomach tumor in rats was studied. Tumor induction was performed by giving MNNG via drinking water for 34 weeks. Ubenimex was ip administered twice a week at 0.5 mg/kg for 84 weeks in one group and 49 weeks in another starting from the first and 36th weeks after initiation of MNNG administration, respectively. The stomachs were endoscopically examined 2 times. At the 64th week after initiation of MNNG administration tumorous lesions were observed with about 70% of the rats in both ubenimex administration groups. In the ubenimex non-administration group nearly 90% of the rats had the lesions. After completion of ubenimex administration almost all the rats had the lesions in the three groups but the sizes were much smaller with the two ubenimex administration groups. Almost all of these lesions were histopathologically identified as tumorous. The tumor volume per rat in the two ubenimex administration groups from the 1 and 36th weeks was 21.0 and 19.2% of the volume in the control group, respectively. Tumor number per rat was similar among the three groups. The natural killer activity of rats was also examined after completion of the above experiment. The activity markedly increased when ubenimex was administered from the 36th week after initiation of MNNG administration. When ubenimex was administered from the first week, the activity did not increase demonstratively. From all the results described above we conclude that ubenimex exerts an inhibitory action against the progression of MNNG-induced stomach tumor in rats. Contribution of the increase of natural killer activity to ubenimex antitumor action may be dependent on schedule of ubenimex administration.
Animals↗
Experimental candidiasis in iron overload.
In an attempt to study the influence of iron overload on deep mycotic infection, experimental candidiasis was induced in mice. One group received intravenous injections of colloidal iron (60 mg/kg weight) for three consecutive days before intravenous inoculation of Candida albicans spores (1 X 10(7). The other received the same number of Candida spores without iron overload. The animals in both groups were observed for 28 days. The Candida lesions, regardless of iron administration, were located mainly in the kidney. There was a marked difference in mortality between the two groups, i.e., 40% in the group without iron administration and 80% in the group with it. The higher mortality rate in the latter group may be explained by following reasons: increased serum iron and iron saturation (iron is essential to the growth of Candida), decreased phagocytic activity against intravenously inoculated Candida because of the saturation of the phagocytic cells by the preceding colloidal iron administration and enhanced proliferation of Candida, which tends to involve the kidney, exposed to abundant iron in the kidney due to increased excretion. The current experiment showed that excessive iron clearly promoted the proliferation of intravenously inoculated Candida in vivo.
Animals↗
Gastric small-cell undifferentiated carcinoma with adeno and squamous cell carcinoma components.
A unique gastric tumor is reported. A large portion of the tumor consisted of a diffuse sheet of undifferentiated cells reminiscent of a small cell undifferentiated carcinoma. The tumor cells showed a few dense core granules and a poorly developed attachment apparatus by electron microscopy. In addition, small portions of the tumor showed adenocarcinoma and squamous cell carcinoma. Another noteworthy finding was that some of the metastatic hepatic nodules consisted of relatively monotonous polygonal cells with a distinct cord-like pattern showing argentaffinity and argyrophilia which were indicative of an atypical carcinoid. This case is a rare example of a gastric tumor with differentiation towards endocrine as well as adeno and squamous cell carcinoma.
Adenocarcinoma↗
Multiple primary malignant fibrous histiocytoma of the stomach and small intestine.
A case of multicentric malignant fibrous histiocytoma of the stomach and small intestine is reported. The patient was a 60-year-old man who had total gastrectomy under an impression of a gastric carcinoma. The resected stomach revealed a large polypoid mass in the antral portion at the greater curvature. Three months later, he developed ileus and an 80 cm segment of the jejunum was removed. It contained two polypoid masses identical to that seen in the stomach. The tumors showed, in addition to the characteristic light microscopic appearances, strong positivity for alpha-1-antitrypsin by an immunoperoxidase technique, indicating the diagnosis of malignant fibrous histiocytoma (MFH). Electron microscopic findings were also consistent with MFH. We believe that this is the first well-documented case of MFH arising from the stomach and small intestine, to the best of our knowledge.
Antigens↗
Suppression of tissue graft rejection by spergualin.
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Animals↗
Enhancement of antitumor effect of cytotoxic agents by bestatin.
Bestatin enhanced the antitumor effects of mitomycin C, 5-fluorouracil and cis-dichlorodiammineplatinum against a syngeneic solid tumor of colon adenocarcinoma 26 in BALB/c mice. The enhancement was dependent on administration schedule. Bestatin administration after treatment with the cytotoxic agents was more effective than that made before the treatment.
Adenocarcinoma↗
[A case of signet ring cell carcinoma of the urinary bladder].
A rare vesical carcinoma, arising in a 47-year-old male, is described. The tumor developed from the left ureteral orifice and posterior urethra, showing a nonpapillary appearance with a wide stalk. By light microscopy, the carcinoma was found to be mainly composed of signet ring cells and associated with small foci of transitional cell carcinoma. The previously reported cases of signet ring cell carcinoma of the urinary bladder were reviewed with a special reference to the manifold potentiality of the urothelium.
Adenocarcinoma, Mucinous↗
[Pre and postoperative education of patients undergoing hysterectomy].
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Female↗
Studies on defense mechanisms against Candida albicans infection in congenitally athymic nude (nu/nu) mice.
The defense mechanisms against Candida albicans infection were studied by using a mouse thigh lesion model in congenitally athymic nude (nu/nu) mice and their normal littermates (nu/+). Nu/nu mice were more resistant to C. albicans infection than nu/+ mice judging from the course of the thigh lesion, the results of CFUs (colony-forming units) of C. albicans in the lesion, and histopathological observations. Histopathological and serological studies revealed that granulocytic cellular infiltration was predominant, and there were few indications of development of cell-mediated immunity to protect Candida infection in Candida-infected nu/nu and nu/+ mice. These results confirmed that lower susceptibility of nu/nu mice to C. albicans infection as compared to nu/+ mice was due to accelerated non-specific defense mechanisms in nu/nu mice, and that cell-mediated or humoral immunity played a minor role in the defense against Candida infection in this experimental model. Furthermore, treatment with high titer of rabbit anti-C. albicans serum was effective to control the number of Candida cells in thigh lesions of BALB/c mice. Above experimental results seem to clearly indicate the great variability of defense manifestation according to the experimental model exployed.
Animals↗
Disseminated fungal infection. A review of 20 autopsy cases.
In the study of disseminated fungal infection, in consecutive autopsy cases between 1974 and 1982, we have found this infection in 20 cases (2.55% in all autopsy cases and 16.8% of deep-seated fungal infection). Candidiasis was present in 11 cases, aspergillosis in 8 cases, and mucormycosis and cryptococcosis in 1 case each. One case showed the disseminated infection by both Candida and Aspergillus. All of the 20 cases had underlying disorders. Hematologic disorders were most frequent and were present in 15 cases. In contrast to the small yellow disseminated foci of candidiasis, the lesion by Aspergillus and Mucor were relatively larger, hemorrhagic, and necrotic. Cryptococcal lesion showed a small gelatinous appearance. All of the fungal lesion were devoid of significant inflammatory reaction. Lymphocytopenia (less than 500/mm3) was present in 13 cases out of 16 cases (not examined in the remaining 4 cases). Eight cases had long-standing indwelling intravenous catheters, including two cases in which the catheters apparently played an important role in the development of disseminated candidiasis. Ante-mortem diagnosis was established or suspected in only seven cases. Possible means of the prevention of fungal infection is also discussed.
Adolescent↗
Renal actinomycosis associated with a duodenorenal fistula caused by foreign body.
We are reporting a case of a rare renal actinomycosis in a 12-year-old mentally-retarded girl. Proteinuria and hemopyuria were pointed out one year before the operation by an annual medical check-up and IVP subsequently performed showed foreign bodies at the upper pole of the right kidney. The patient continued to have pyuria and right nephrectomy was performed. There was a fistula between the duodenum and the upper portion of the right kidney. Foreign bodies (two bobby pins) were found in the kidney. Subsequent pathologic examination of the resected kidney revealed an actinomycotic lesion.
Actinomycosis↗
Systemic amyloidosis associated with factor X deficiency.
An autopsy case of amyloidosis associated with factor X deficiency is reported. The patient showed a markedly decreased level of factor X (9% normal) and an extremely shortened half-life of intravenously infused factor X. Amyloid deposition was present in most of the visceral organs with special involvement of the liver and spleen. The amyloid in this case was thought to be AL protein, since it was potassium-permanganate-resistant and a small amount of Bence Jones protein was detected after dimethyl sulfoxide therapy. Electron microscopic study revealed a typical appearance of amyloid fibrils radiating from invaginated cell membrane of Kupffer cells, which may indicate rather rapid turnover of the amyloid. Rapidity and severity of amyloid deposition, especially in the liver and spleen, may play an important role in the development of the factor X deficiency associated with systemic amyloidosis.
Amyloid↗
Inhibitory presynaptic effect of noradrenaline on the hypogastric ganglion of the guinea pig.
The effect of noradrenaline on the hypogastric ganglion of the guinea pig was studied to establish the role of catecholamine-containing sites in the sympathetic ganglia with the hypogastric nerve-vas deferens preparation. In these experiments the ganglion was separated pharmacologically from the muscle by a partition. An application of noradrenaline, adrenaline and isoproterenol each to the ganglion inhibited a twitch response of the vas deferens to preganglionic nerve stimulation at low frequencies. The drug effect decreased with increasing frequencies of stimulation. The inhibitory action of these drugs was antagonized by phentolamine, but not by propranolol. Clonidine also reduced the response to the nerve stimulation in a similar manner as did catecholamines, and the inhibitory action was antagonized by phentolamine. In contrast, phenylephrine had no significant action. The inhibitory effect of noradrenaline and clonidine was antagonized by the alpha-2 antagonist yohimbine, but not by such alpha-1 antagonists as prazosin and E-643. Noradrenaline did not affect the ganglion-stimulating action of acetylcholine. These results suggest that the inhibitory action of noradrenaline may be mediated by alpha-2 adrenoceptors on presynaptic cholinergic nerve endings of the guinea-pig hypogastric ganglion. These data are discussed in relation to the presence of noradrenaline-containing sites in this ganglion.
Acetylcholine↗