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Biomedical subjects

F A Struve

Publications and source records attributed to F A Struve.

54 records · Page 3Linked to original sources
PubMed1979

Relationship between the B-mitten EEG pattern and tardive dyskinesia. A pilot control study.

The identification of patients at high risk for the development of tardive dyskinesia (TD) is a major problem in psychopharmacology. We found a possible relationship between the subcortical B-mitten EEG pattern and TD. Twenty-one TD pateints were matched on a number of relevant variables with 21 patients without TD. Ninety-five percent of the TD patients had mittens, compared to 33.3% of controls. The results suggest that the mitten dysrhythmia may be a risk factor for the development of TD. Additional findings suggest that among TD patients, mittens are differentially more frequent in younger (93.1%) as opposed to older (0.0%) subjects.

Adolescent↗
PubMed1979

Electroencephalographic correlates of compulsive eating.

Fifty-nine compulsive eaters were interviewed, had a complete waking and sleep EEG tracing, and were offered a trial with phenytoin. Forty-seven patients had an adequate pharmacological intervention. Analyses of the EEGs showed a disproportionately higher percentage of abnormal EEGs and of paroxysmal EEGs in particular among compulsive eaters as contrasted with unselected psychiatric patients and normal controls. Patients with abnormal EEGs responded to phenytoin treatment statistically more frequently than those with normal EEGs--even after conservatively classifying "uncertain" patients as non-responders. Patients with 14 & 6/sec. positive spikes alone showed a phenytoin improvement significantly greater than that seen with either normal EEG subjects or other EEG abnormalities. There are suggestions of a weight by EEG interaction in that the combination of weight deviance (viz: emaciated or obese) plus abnormal EEG seems especially highly predictive of good phenytoin response. The EEG results combined with phenytoin response suggest that neurophysiological etiological hypotheses may have merit for some compulsive eating disorders. Suggestions for additional research are made and the need for controlled replication of these data results is stressed.

Adult↗
PubMed1977

Incidence of the 14 and 6 per second positive spike pattern in an adult clinical population: an empirical note.

Although 14 and 6 per second positive spiking in children and adolescents has received extensive investigative attention resulting in conflicting results and opinion, efforts to study this finding in adult populations have been almost totally neglected. The present study attempts to contrast the incidence of this EEG finding in an adult clinical psychiatric sample with similar incidence data derived froma historical normal adult control series. From 10 years of laboratory data, the presence or absence of positive spikes was noted in the waking and sleep EEGs of 2888 psychiatric patients aged 20 and above. These incidence figures were contrasted with similar data derived from the EEG'S of 619 normal adults of similar age collected in a previously published control series. A differentially higher incidence of positive spiking in the adult clinical population as contrasted with the adult normal control population occurred with a high level of statistical significance. Methodological and technological aspects of electroencephalographic recording for the current clinical group and the historical control population are felt to be virtually identical and the possible effect of differential recording or interpretive practice confounding the present results does not seem plausible. The present results offer no solution or resolution of the positive spike controversy. They do, however, suggest that additional focus on this EEG signal in adults may possibly have merit.

Adult↗
PubMed1976

Analogical reasoning and postoperative outcome. Predictions for patients scheduled for open heart surgery.

We investigated whether postoperative outcome of open heart surgery is related to preoperative cognitive dysfunction. Patients ill enough to require open heart surgery frequently have gravely compromised circulation and, hence, possible brain damage. The Conceptual Level Analogy Test (CLAT), a new, rigorously constructed analogy test, was used to measure cognitive dysfunction. The results indicated that the CLAT, aministered preoperatively to open heart surgery patients, differentiated between patients having different types of postoperative outcome. A significant relationship between type of surgical procedure and poor postoperative outcome was also found; cardiac valvular surgery patients had significantly worse outcome than coronary bypass surgery patients. The incidence of good outcome (survival with no psychiatric complications) was 28% for cardiac valvular surgery patients with extremely poor preoperative CLAT scores, but 74% for valvular surgery patients with higher preoperative CLAT scores.

Cardiac Surgical Procedures↗
PubMed1976

Electroencephalographic correlates of oral contraceptive use in psychiatric patients.

Previous studies have pointed to wake electroencephalographic changes associated with oral contraceptives. This investigation sought to determine if sleep EEG activation would show additional EEG-oral contraceptive relationships not previously suspected. With blind procedures, oral contraceptive and EEG data were collected on 110 adult women. Three age-equated comparison groups were formed: (1) never used pill (control); (2) previously used pill without side effects (asymptomatic); and (3) previously used pill with side effects (symptomatic). Analyses indicated a significant statistical relationship between paroxysmal EEGs and symptomatic pill use. No difference in paroxysmal EEG incidence existed between control and asymptomatic pill use groups. Among prior pill users, women with paroxysmal EEGs reported almost twice the side effect incidence (81.3%) as did women with normal EEGs (42.1%).

Contraceptives, Oral↗
PubMed1976

Diagnostic implications of the B-mitten EEG pattern: relationship to primary and secondary affective dysregulation.

Previous studies indicate that the B-Mitten EEG pattern is specific to psychiatric dysfunction and rarely encountered among normal control subjects. Our previous investigations have demonstrated a significant relationship between mittens and reactive as opposed to process schizophrenic disease. Re-analyses of mitten incidence in schizophrenics and nonschizophrenics suggests needed modification of our earlier B-Mitten-schizophrenia formulation. Present considerations indicate that the B-Mitten-reactive schizophrenia association is not primary but rather that the differential process-reactive schizophrenia mitten incidence may be a secondary epiphenomenon reflecting a more fundamental underlying process. Analyses are presented suggesting that the mitten dysrhythmia relates positively to dysphoric affective dysregulation in a manner which cuts across broad diagnostic boundaries. That the mitten pattern possibly suggests as yet unclarified subcortical dysfunction associated with symptoms of affective disturbance is a tentative hypothesis offered for consideration.

Adult↗