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Biomedical subjects

F A Ofodile

Publications and source records attributed to F A Ofodile.

32 records · Page 2Linked to original sources

Vitamins and trace elements profiles in chronic leg ulcers in Nigerians.

This report discusses vitamins and trace elements profiles in Nigerians suffering from chronic leg ulcers. The levels of vitamin A, C and E are significantly lower than levels in healthy Nigerian controls. Copper values are almost the same in the two groups, but the results indicate deficiency of zinc. The relationship of these nutrients to wound healing is discussed; the addition of vitamin E in the management of leg ulcers is recommended.

Ascorbic Acid↗

Acrocephalosyndactyly with hydrocephalus and dextrocardia in a Nigerian child.

A rare case of dextrocardia and hydrocephalus in a patient with acrocephalosyndactyly is reported. In the patient presented here, barium meal studies showed the gastrointestinal tract to be in normal position. There was no evidence of cardiac disease but the patient showed some neurological retardation at age nine months.

Abnormalities, Multiple↗

Hemangiomas in Nigeria.

Forty cases of hemangioma in black Nigerians are presented. Twenty-eight patients were female and 20 male. Of these cases 43.8 percent were discovered at birth and 77 percent were located in the head and neck areas. Forty-eight percent of the lesions were of the cavernous type and 29 percent of the strawberry variety. There was a positive family history of hemangioma in only two percent of cases. Associated anomalies, treatments, and complications are also presented.

Adolescent↗

Post-circumcision epidermoid inclusion cysts of the clitoris.

We describe our experiences during the last 5 years with 19 cases of epidermoid inclusion cysts of the clitoris resulting from circumcision. There were 14 children and 5 adults. The management consisted of complete excision of the cyst, and reconstruction of the clitoris, wherever possible.

Adolescent↗

Tropical ulcers.

We present 87 cases of chronic leg ulcers. The ages and sexes of the patients, and the symptomatology and complications, are described. The term "tropical ulcer" is inappropriate for these cases--though the term may be appropriate for certain rare acute ulcers colonized by Vincent's bacilli. For most persistent leg ulcers in the tropics, however, a general term of chronic ulcer is better--because it stimulates one to look for the cause and to treat the patient accordingly.

Adolescent↗

Hypospadias in Nigeria.

We present a review of 42 cases of hypospadias seen at the University College Hospital in Ibadan, Nigeria from 1969 to 1977. The incidence was low. No family history of hypospadias was noted in any of these patients. Fifty-seven percent had associated anomalies--mostly of the genitourinary system. Most of the patients had been circumscribed on arrival for treatment.

Abnormalities, Multiple↗

Progressive hemifacial atrophy.

Twenty-three cases of progressive hemifacial atrophy with their modalities of treatment have been reviewed. The importance of and need for proper planning and a coordinated approach are stressed. Generally, the final result has been highly satisfactory to the patient.

Adipose Tissue↗

Neoplastic change in chronic leg ulcer.

Seventeen cases of chronic leg ulcers were examined, 12 males and five females, with a mean age of 45 years. The average duration of ulcers was 21 years. Eleven of the cancers arose from ulcers that recurrently healed and broke down. Three arose from ulcers that never healed and three from stable scars. Treatment was by various levels of amputation in nine patients and by excision and skin grafting in one. Histological findings showed 16 cases to be squamous cell carcinoma while one case was sarcomatous in appearance. Most of the cases were poorly differentiated and findings of pseudoepitheliomatous hyperplasia were significant. This was thought to represent earlier stages of fetoplasia which in itself may continue for many years and may be a prelude to frank neoplasia. It was therefore suggested by the authors that the laboratory study of fetal antigens or other fetal markers in these types of lesions may be useful. It was also suggested that careful examination of deeper tissues in lesions where pseudoepitheliomatous hyperplasia has been found is necessary to ascertain that there is no undetected malignancy.

Adolescent↗