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Biomedical subjects

F A Murphy

Publications and source records attributed to F A Murphy.

At least 127 records · Page 7Linked to original sources
PubMed1969

Internal and surface structure of Hong Kong influenza virus.

Negative-contrast electron-microscope studies of the A2/Aichi/2/68 strain of the Hong Kong influenza virus variant have revealed structural details which are compared with those of other influenza viruses.The structures of the ribonucleoprotein strand and of the virus envelope, in particular, are illustrated at magnifications of from x200 000 to x330 000.The authors conclude that by the microscope technique used the Hong Kong virus is indistinguishable from earlier influenza A viruses and similar in general design to influenza C viruses.

Microscopy, Electron↗
PubMed1968

Cellular immunity in vaccinia infection of mice. Anti-thymocyte serum effects on primary and secondary responsiveness.

Rabbit anti-mouse thymocyte serum suppressed host cell-mediated responsiveness to intravenously administered vaccinia virus, thereby augmenting the morbidity and mortality of this infection. It did not affect either humoral antibody or interferon production in response to vaccinia virus. No effects were noted on primary or secondary immunity to intracerebral virus inoculation.

Animals↗
PubMed1968

Agent of disease contracted from green monkeys.

An infectious agent obtained from patients who became ill after exposure to tissues of African green monkeys is viral in character. By electron microscopy, the agent appeared cylindrical, 90 to 100 nanometers in diameter, and 130 to 2600 nanometers in length. Cross-striations at 5-nanometer intervals and a core diameter of 45 nanometers were observed. The agent was completely resistant to the effects of the metabolic inhibitor 5-bromodeoxyuridine, which may mean that RNA is the genetic material. It was sensitive to ether and relatively sensitive to destruction by heat.

Animals↗
PubMed1968

Immunopathology of lymphocytic choriomeningitis viurs infection of newborn mice. Antithymocyte serum effects on glomerulonephritis and wasting disease.

Antithymocyte serum, when administered neonatally to mice, delayed the maturation of the lymphoid system, permitting development of cellular tolerance to LCM virus at an older age than is ordinarily possible. Humoral antibody formation was not prevented and the animals exhibited the paradox of high titers of both circulating virus and antibody. This, in turn, was followed by a chronic immunopathologic glomerulonephritis in most animals. Some animals developed wasting disease between 1 and 2 months of age, characterized by reticular cell hyperplasia and widespread infiltration into tissues and organs.

Animals↗
PubMed1968

Electron microscopic observations of mouse brain infected with Bunyamwera group arboviruses.

Ultrathin sections of brain tissue from mice infected with three Bunyamwera group arboviruses, Bunyamwera, Tensaw, and Maguari, were examined by electron microscopy. In all three cases, virus was observed budding from membranes into intracytoplasmic cisternae. Mature virus was found accumulated within these distended cisternae and in extracellular spaces. The three viruses were morphologically indistinguishable; particles were round or oval, 98 nm in diameter, and had a closely adherent irregular envelope.

Animals↗